Turmeronols (A and B) from Curcuma longa have anti-inflammatory effects in lipopolysaccharide-stimulated BV-2 microglial cells by reducing NF-κB signaling.

Abstract

Turmeronols (A and B), bisabolane-type sesquiterpenoids found in turmeric, reduce inflammation outside the brain in animals; however, their effects on neuroinflammation, a common pathology of various neurodegenerative diseases, are not understood. Inflammatory mediators produced by microglial cells play a key role in neuroinflammation, so this study evaluated the anti-inflammatory effects of turmeronols in BV-2 microglial cells stimulated with lipopolysaccharide (LPS). Pretreatment with turmeronol A or B significantly inhibited LPS-induced nitric oxide (NO) production; mRNA expression of inducible NO synthase; production of interleukin (IL)-1β, IL-6, and tumor necrosis factor α and upregulation of their mRNA expression; phosphorylation of nuclear factor-κB (NF-κB) p65 proteins and inhibitor of NF-κB kinase (IKK); and nuclear translocation of NF-κB. These results suggest that these turmeronols may prevent the production of inflammatory mediators by inhibiting the IKK/NF-κB signaling pathway in activated microglial cells and can potentially treat neuroinflammation associated with microglial activation.

• Authors: Ryosuke Saji, Ryusei Uchio, Arisa Fuwa, Chinatsu Okuda-Hanafusa, Kengo Kawasaki, Koutarou Muroyama, Shinji Murosaki, Yoshihiro Yamamoto, Yoshitaka Hirose
• Journal: Bioscience of microbiota, food and health (Biosci Microbiota Food Health) Vol. 42 Issue 3 Pg. 172-179 ( 2023) ISSN: 2186-6953 [Print] Japan
• PMID: 37404570 (Publication Type: Journal Article)
• Copyright: ©2023 BMFH Press.