Abstract | Background: Materials and method: There was a single oropharyngeal administration of bleomycin (80 mg/kg) in mice followed by the treatment of CAE and BET after 48 h of exposure to BLM. Results: There was increased survival rate in CAE and BET treatment groups compared to the BLM induced group. There was a marked decreased in the levels of hydroxyproline, collagen I and III in the CAE and BET treatment groups compared to BLM-treated group. The treatment groups of CAE and BET significantly down regulated the levels of pro-fibrotic and pro-inflammatory cytokines concentrations such as TGF-β1, MMP9, IL-6, IL-1β and TNF-alpha compared to an increased in the BLM treated groups. The histological findings of the lungs suggested the curative effects of CAE and BET following BLM induced pulmonary fibrosis in mice, the study showed improved lung functions with wide focal area of viable alveolar spaces and few collagen fibers deposition on lungs of treatment groups. Conclusion: CAE and BET attenuated pulmonary fibrosis by down regulating pro-fibrotic and pro-inflammatory cytokines as well as improving lung function. This could be a lead in drug discovery where compounds with anti-fibrotic effects could be developed for the treatment of lung injury.
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Authors | Michael Ofori, Cynthia Amaning Danquah, Joshua Asante, Selase Ativui, Peace Doe, Alhassan Abdul-Nasir Taribabu, Isaac Newton Nugbemado, Adwoa Nkrumah Mensah |
Journal | Heliyon
(Heliyon)
Vol. 9
Issue 6
Pg. e16914
(Jun 2023)
ISSN: 2405-8440 [Print] England |
PMID | 37346329
(Publication Type: Journal Article)
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Copyright | © 2023 The Authors. |