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Transforming Growth Factor beta (TGF-beta)

A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
Also Known As:
TGF-beta; Milk Growth Factor; TGFbeta; Bone Derived Transforming Growth Factor; Factor, Milk Growth; Growth Factor, Milk; Bone-Derived Transforming Growth Factor; Platelet Transforming Growth Factor
Networked: 13953 relevant articles (319 outcomes, 1572 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Miyazono, Kohei: 37 articles (06/2019 - 01/2002)
2. Moses, Harold L: 35 articles (11/2015 - 12/2002)
3. Mishra, Lopa: 28 articles (01/2022 - 12/2004)
4. Schiemann, William P: 27 articles (07/2015 - 04/2002)
5. Leask, Andrew: 26 articles (01/2021 - 01/2002)
6. Roberts, Anita B: 26 articles (03/2010 - 02/2002)
7. Flavell, Richard A: 25 articles (12/2013 - 06/2002)
8. Flanders, Kathleen C: 25 articles (06/2010 - 03/2002)
9. Arteaga, Carlos L: 25 articles (01/2010 - 06/2002)
10. Varga, John: 24 articles (05/2012 - 04/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Fibrosis (Cirrhosis)
3. Inflammation (Inflammations)
4. Neoplasm Metastasis (Metastasis)
5. Necrosis

Related Drugs and Biologics

1. Transforming Growth Factor beta (TGF-beta)
2. Cytokines
3. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4. Collagen
5. Interleukin-10 (Interleukin 10)
6. Messenger RNA (mRNA)
7. Vaccines
8. Transforming Growth Factor beta1 (TGF beta 1)
9. Interleukin-2 (IL2)
10. Transforming Growth Factors (Transforming Growth Factor)

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Immunotherapy
4. Vitrectomy
5. Radiotherapy