betulin

isolated from various white birch bark (BETULA)

Also Known As:

(+)-betulin; (+)-betulin diacetate; 3,28-di-O-acetylbetulin; 3,28-diacetoxy-betulin; betulin diacetate; betuline; betulinic alcohol; betulinol; betulinol biacetate; betulinol diacetate; lup-20(29)-en-3 alpha, 28,30-triol; lup-20(29)-ene-3 beta,28-diol; lup-20(29)-ene-3,28-diol, 3,28-diacetate, (3 beta)-; lup-20(29)-ene-3alpha,28-diol

Networked: 223 relevant articles (21 outcomes, 57 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - Pentacyclic Triterpenes: 108
        Lupanes: 28
        Betulinic Acid: 545
        betulin: 223

Experts

1.	Boryczka, Stanisław: 14 articles (02/2022 - 04/2013)
2.	Bębenek, Ewa: 13 articles (02/2022 - 04/2013)
3.	Chrobak, Elwira: 7 articles (02/2022 - 01/2017)
4.	Chodurek, Ewa: 6 articles (01/2021 - 02/2014)
5.	Orchel, Arkadiusz: 5 articles (01/2021 - 02/2014)
6.	Paschke, Reinhard: 4 articles (08/2021 - 06/2010)
7.	Kadela-Tomanek, Monika: 4 articles (01/2021 - 01/2017)
8.	Kasperczyk, Janusz: 4 articles (01/2021 - 12/2016)
9.	Alakurtti, Sami: 4 articles (12/2020 - 02/2010)
10.	Yli-Kauhaluoma, Jari: 4 articles (12/2020 - 02/2010)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2018 - "The present study therefore offers novel insights into the mechanism of action of the natural compound betulin against tumors." 07/28/2023 - "Thus, to improve the solubility and bioavailability so as to improve the efficacy, 28-O-succinyl betulin (SBE), a succinyl derivative of BE, was synthesized and its solubility, in vitro and in vivo anti-tumor activities, the apoptosis pathway as well as the pharmacokinetic properties were investigated. " 01/01/2022 - "Notably, betulin increased significantly the number of CD69 positive NK cells in tumor sites at early stages of post-tumor cell injection. " 12/03/2021 - "By regulating these diverse pathways, betulin can not only affect the development and progression of different cancers, but also enhance the antitumor action of traditional therapeutic modalities. " 01/01/2021 - "An MTT-based cell viability assay showed that ABCC1 overexpression has the ability to desensitize both cancer cell line and gene-transfected cell line to betulin and that this betulin-induced resistance can be antagonized by a known ABCC1 inhibitor MK571 at 25 μM. "
2.	Inflammation (Inflammations) 07/01/2022 - "The gene expression studies revealed that betulin in 40 mg/kg dose has positive effects for carbohydrate metabolism in liver, lowers the hepatic inflammation and increases insulin secretion. " 01/01/2021 - "This study is aimed to explore whether betulin can suppress IL-1β-induced inflammation in chondrocytes and alleviate OA in vitro and in vivo. " 12/01/2023 - "This review focuses on the natural sources, pharmacokinetics, pharmacological activity of betulin, and the multi-target effects of betulin on signaling pathways such as MAPK, NF-κB, and Nrf2, which are important regulators of the response to oxidative stress and inflammation in the body." 04/01/2023 - "Betulin and Its Derivatives Reduce Inflammation and COX-2 Activity in Macrophages." 01/01/2021 - "Betulin, a natural product extracted from birch bark, has been commonly used for inflammation treatment; however, its role in OA remains unclear. "
3.	Melanoma (Melanoma, Malignant) 01/19/2023 - "A betulin-derived conjugate held a Ki = 0.129 μM and an EC50 = 8.5 μM for human A375 melanoma cells." 12/31/2016 - "A relatively new approach in treatment of malignant melanoma is the use of betulin and its synthetic derivatives that have anticancer properties. " 07/01/2015 - "Acetylenic derivatives of betulin were tested in vitro for their antiproliferative activity against G-361 human melanoma cells. " 07/01/2015 - "ANTIPROLIFERATIVE ACTIVITY OF NOVEL ACETYLENIC DERIVATIVES OF BETULIN AGAINST G-361 HUMAN MELANOMA CELLS." 01/01/2015 - "Simultaneous and dose dependent melanoma cytotoxic and immune stimulatory activity of betulin."
4.	Breast Neoplasms (Breast Cancer) 05/01/2021 - "We present a nanosuspension of betulin, a BCS class II anticancer drug, particularly effective against resistant breast cancer. " 07/01/2021 - "Betulin ameliorates 7,12-dimethylbenz(a)anthracene-induced rat mammary cancer by modulating MAPK and AhR/Nrf-2 signaling pathway." 01/25/2021 - "In this study, a comparative assessment of the in vitro anticancer activity of betulin and its four derivatives was carried out using two human breast cancer cell lines: SK-BR-3 and MCF-7. " 05/01/2021 - "Significantly higher cytotoxicity of BeTNS-15 (IC50 38.44 µg/ml) compared to betulin (BetS) (IC50 69.54 µg/ml) in the resistant triple negative human breast cancer cell line MDA-MB-231, was attributed to high intracellular uptake confirmed by HPLC and Imaging Flow cytometry (IFC). " 12/01/2020 - "Apoptosis Induced by (+)-Betulin Through NF-κB Inhibition in MDA-MB-231 Breast Cancer Cells."
5.	Wounds and Injuries (Trauma) 08/14/2020 - "In vitro drug release and ex vivo permeation studies indicated that the electrospun nanofibers showed a sustained release of betulin, the main component of birch bark dry extract, making the examined dressings highly applicable for several wound care applications. " 09/01/2017 - "The goal of this combined study program consisting of two randomized phase III clinical trials in parallel is to evaluate whether a topical betulin gel (TBG) is accelerating re-epithelialization of split-thickness skin graft (STSG) donor site wounds compared to standard of care. " 09/01/2017 - "Accelerated re-epithelialization of partial-thickness skin wounds by a topical betulin gel: Results of a randomized phase III clinical trials program." 09/01/2022 - "Therefore, it is necessary to investigate the wound repair effects and validate the mechanism of betulin in an appropriate model. " 01/01/2019 - "Betulin wound gel accelerated healing of superficial partial thickness burns: Results of a randomized, intra-individually controlled, phase III trial with 12-months follow-up."

Related Drugs and Biologics

1.	Betulinic Acid
2.	Esters
3.	28-O-propynoylbetulin
4.	Antioxidants
5.	Aspartate Aminotransferases (Aspartate Transaminase)
6.	Amino Acids
7.	Organophosphonates (Phosphonates)
8.	Emulsions
9.	9,10-Dimethyl-1,2-benzanthracene
10.	Silver

Related Therapies and Procedures

1.	Therapeutics
2.	Lasers (Laser)
3.	Combination Drug Therapy (Combination Chemotherapy)
4.	Skin Care
5.	Palliative Care (Palliative Therapy)