Lung Injury

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6035 relevant articles (377 outcomes, 755 trials/studies) found for this Disease

Description: Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.

Also Known As:

Chronic Lung Injury; Lung Injuries; Pulmonary Injury; Chronic Lung Injuries; Injuries, Lung; Injuries, Pulmonary; Injury, Lung; Injury, Pulmonary; Lung Injuries, Chronic; Lung Injury, Chronic; Pulmonary Injuries

Relationship Network

Disease Context: Research Results

Respiratory Tract Diseases: 377

Lung Diseases: 8942

Lung Injury: 6035

Acute Lung Injury: 3193

Pneumoconiosis: 1172

Meconium Aspiration Syndrome: 315

Radiation Pneumonitis: 301

Ventilator-Induced Lung Injury: 242

Related Diseases

1.	Ischemia
2.	Hyperoxia
3.	Acute Lung Injury
4.	Inflammation
5.	Pancreatitis

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Lung Injury:

1.	OxygenIBA 01/01/2008 - "Strategies in ventilation and in exposure to the oxygen that minimise lung injury improved the prognosis of the extremely low weight newborns. " 05/01/1993 - "Arterial oxygen tension and pulmonary compliance deteriorated abruptly after lung injury in all cats, and improved significantly (p < .001, two-way analysis of variance) 15 mins after perfluorochemical liquid lavage. " 03/01/1998 - "Intraperitoneal administration of MR1, either before or after oxygen exposure, was remarkably effective in reducing and in many cases preventing lung injury. " 09/30/1991 - "An increasing number of animal studies indicate efficacy for this agent in the prevention and therapy of lung injury involving toxic oxygen species. " 02/01/2009 - "Likewise, improved knowledge of NO-based mechanisms of pulmonary oxygen toxicity may enhance our understanding of other types of lung injury associated with oxidative or nitrosative stress." Order ALL the reference details at left...
2.	Bleomycin (Blenoxane)FDA LinkGeneric 05/01/2005 - "The aim of our study was to evaluate the therapeutic efficacy of in vivo inhibition of PARP in an experimental model of lung injury caused by bleomycin administration. " 08/01/2005 - "We sought to determine whether an intact bone marrow is essential to lung repair following bleomycin-induced lung injury in mice, and the mechanisms of any protective effects conferred by bone marrow-derived mesenchymal stem cell (BMDMSC) transfer. " 08/01/2007 - "It has previously been shown that CD44 can modulate macrophage recruitment in response to Mycobacterium tuberculosis, as well as clearance of neutrophils after lung injury with both bleomycin and live Escherichia coli bacteria. " 04/01/1993 - "It was postulated that renal tubular injury prolonged the renal clearance of bleomycin, intensifying the patient's pulmonary exposure to this drug and increased the susceptibility to pulmonary injury at lower than expected cumulative doses of bleomycin. " 06/01/2008 - "Previous studies have demonstrated that bone marrow-derived mesenchymal stem cell (MSC) engraftment attenuated lung injury in a model induced by bleomycin in mice. " Order ALL the reference details at left...
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/01/2006 - "In the event of a pandemic with a highly virulent virus, intervention directed at TNF-alpha should be given consideration, as this may be most likely to provide protection against severe lung injury at the lowest cost to viral clearance." 01/01/2009 - "Treatment of animals with a PPS aerosol significantly increased the phospholipid content in the BALF, improved lung function, reduced pulmonary oedema, decreased total protein and TNF-alpha concentrations in BALF, ameliorated lung injury and improved animal survival. " 12/01/2000 - "The relationship between TNF-alpha, gut toxicity, and lung injury was examined further by direct cytokine blockade in vivo; systemic neutralization of TNF-alpha resulted in a significant reduction in gut histopathology, BAL fluid LPS levels, and pulmonary dysfunction compared with control-treated animals. " 05/01/2008 - "This study was performed to determine whether the lectin-like domain of tumor necrosis factor-alpha (designated TIP) can improve fluid balance in experimental lung injury by affecting alveolocapillary permeability and/or fluid clearance. " 01/01/2006 - "This study examined the association of the increased release of TNF-alpha with increased myocardial and lung injury after CPB and its effect on postoperative morbidity. " Order ALL the reference details at left...
4.	Oleic Acid (Oleate)IBA 07/01/2008 - "Compared with CMV, HFOV significantly improved the deteriorated oxygenation during the late phase (2-4 h) of oleic acid-induced lung injury without any deterioration effects on pulmonary or systemic hemodynamics. " 08/01/1999 - "CONCLUSION: Vaporization is a new application technique for perfluorocarbon that significantly improved oxygenation and pulmonary function in oleic acid-induced lung injury." 07/01/2008 - "These findings suggest that HFOV could contribute to decreased lung lymph filtration in pulmonary microcirculation and improved oxygenation following oleic acid-induced lung injury in sheep." 02/01/2004 - "CONCLUSION: Treatment of oleic acid-induced lung injury with PFH vapor improved oxygenation and mechanical lung function over a extended time period allowing a reduction in the invasiveness of ventilation." 01/01/1998 - "The delayed onset of symptoms suggested that the lung injury was due to the systemic circulation of oleate to the lungs rather than to direct aspiration. " Order ALL the reference details at left...
5.	Antigen-Antibody Complex (Immune Complex)IBA 03/15/1992 - "Although anti-CD11b was not effective under the same experimental conditions, intratracheal administration of this antibody conveyed protection against immune complex-induced lung injury, suggesting that both CD11b and CD18 are required for the full expression of injury. " 01/01/2000 - "These results suggest that anti-CK18 antibody and its immune complex may have played a role in the process of lung injury in IPF." 05/01/1994 - "Our findings suggested an immune complex-mediated pulmonary injury that was possibly related to the systemic nature of IgAN." 08/01/1992 - "Using a well-characterized rat model of immune complex-mediated acute inflammatory lung injury, we determined that there is a time-dependent elaboration of monocyte chemotactic activity in bronchoalveolar lavage fluid. " 12/01/1991 - "Sequential changes in lung injury induced by preformed immune complexes." Order ALL the reference details at left...
6.	Immunoglobulin G (IgG)IBA 03/01/2000 - "The T/P ratio and BAL neutrophil counts were conspicuously decreased by pretreatment with anti-IL-8 Ab, but not with control IgG. On a histopathological study, lung injury and leukocyte infiltration were attenuated by the pretreatment with anti-IL-8 Ab. " 06/01/2008 - "aeruginosa-induced lung injury or rate of survival compared to pretreatment with control immunoglobulin G. " 07/01/2006 - "We further show that activation of STAT3 was inhibited by SOCS3 overexpression as well as by anti-IL-6 treatment during IgG IC-induced lung injury, as determined by EMSA. " 04/01/2006 - "In the antibody-treated group, lung injury and mortality increased compared with animals treated with rabbit immunoglobulin G. " 04/01/2000 - "In contrast, IgG-GOX caused a minor lung injury and little (5%) lethality. " Order ALL the reference details at left...
7.	Nitric Oxide (Nitrogen Monoxide)FDA Link 09/01/1999 - "We have tested if inhaled nitric oxide (NO) is beneficial in ischaemia-reperfusion (IR) lung injury using an isolated perfused rabbit lung model. " 03/01/1998 - "Protective effects of intravascular pressure and nitric oxide in ischemic lung injury." 11/01/1996 - "OBJECTIVE: To evaluate the efficacy of nitric oxide (NO) inhalation against endotoxin-induced lung injury. " 10/20/2002 - "AIMS: The aim of our study was to evaluate the severity of different levels of ischaemia-reperfusion related lung injury by measuring nitric oxide in the exhaled air. " 05/01/2008 - "Therefore, we assessed the roles of several reactive species, particularly nitric oxide, in pulmonary injury by exposing wild-type mice and seven groups of genetically altered mice to >98% O2 at 1, 3, or 4 atmospheres absolute. " Order ALL the reference details at left...
8.	ParaquatIBA 01/01/2008 - "Anti-TGF-beta1 antibody: an effective treatment for lung injury caused by paraquat in the future." 06/01/2009 - "The purpose of this study was to report the long-term evolution of lung lesions in eight survivors with significant paraquat-induced lung injuries who could be followed-up for longer than 6 months. " 10/12/2004 - "The aim of this study was to evaluate the time course of in vivo and in vitro respiratory mechanics and examine whether these parameters could reflect the temporal changes in lung parenchyma remodelling in paraquat (PQ)-induced lung injury. " 09/01/1992 - "The purpose of this study was to establish a chronic model of paraquat-induced lung injury. " 01/01/1989 - "An immunohistochemical study of the fibrosing process in paraquat lung injury." Order ALL the reference details at left...
9.	SmokeIBA 05/01/2000 - "The delayed pulmonary effects and improved splanchnic blood flow suggested that LAM1-3 attenuated the development of a systemically induced secondary lung injury rather than of the primary lung injury associated with smoke inhalation." 02/01/2009 - "In vitro systems are frequently used to study mechanisms of mainstream cigarette smoke (MS)-induced lung injury. " 01/01/2009 - "This review represents a toxicological approach to investigation of cigarette smoke-induced lung injury, with a focus on laboratory studies and an emphasis on inflammatory mechanisms. " 10/01/2006 - "C57BL/6 mouse groups were subjected to smoke from 3, 6 or 12 LC for 60 days and compared with mice exposed to ambient air (EAA) in order to study lung injury by morphometrical and biochemical methods. " 08/10/2001 - "In this study, we investigated the mediator mechanisms of this delayed smoke-induced lung injury in 126 anesthetized and artificially ventilated guinea pigs who received challenges of either air or 40 tidal breaths of wood smoke. " Order ALL the reference details at left...
10.	Peroxidase (Myeloperoxidase)IBA 04/01/2009 - "It was noted that in severe lung injury, myeloperoxidase activity in the blood increased significantly, but still reflected the processes taking place in the lung parenchyma. " 10/01/2008 - "There was a corresponding reduction in lung injury, as demonstrated by reduced myeloperoxidase content and reduced wet-to-dry ratio. " 09/01/2008 - "Pancreatic and pulmonary injury was assessed by histology, wet-to-dry weight ratio, and myeloperoxidase activity. " 08/01/2008 - "Lung injury was assessed histologically and by the magnitude of neutrophil sequestration as reflected in myeloperoxidase levels. " 01/01/2008 - "Lung oedema, myeloperoxidase and histological lung injury score were higher in the HVCMV group, but not different among all others. " Order ALL the reference details at left...

Therapies and Procedures

1.	Positive-Pressure Respiration (PEEP) 01/01/2007 - "Low Vt/high PEEP stabilized alveoli, improved oxygenation, and reduced lung injury. " 05/01/1994 - "Lung injury assessed morphologically was significantly greater in the groups ventilated with a PEEP below Pinf, and in these groups the site of injury was dependent on the level of PEEP. " 11/01/2008 - "We aimed to evaluate whether PEEP and/or tidal volume (VT) within the first 15-min of ventilation are protective against lung injury. " 01/01/2004 - "CONCLUSIONS: The combination of fluorocarbon and PEEP improved the physiologic, biochemical, and histologic lung injury induced by acidified infant formula. " 12/01/2001 - "CONCLUSIONS: During unilateral lung injury, PLV with a moderate PEEP did not improve oxygenation, TGI superimposed on PLV improved gas exchange, and combination of TGI and PLV allowed a 77% reduction in VT without any adverse effect on PaCO(2)." Order ALL the reference details at left...
2.	Mechanical Ventilators (Ventilator) 04/01/2005 - "Protective effects of low respiratory frequency in experimental ventilator-associated lung injury." 05/01/2008 - "Volutrauma and atelectrauma have been proposed as mechanisms of ventilator-associated lung injury, but few studies have compared their relative importance in mediating lung injury. " 06/01/2007 - "Studies of ventilator-associated lung injury in subjects without ALI demonstrate inconsistent results. " 03/01/2007 - "The purpose of this study was to characterize the effects of doubling minute ventilation (either by doubling ventilator frequency [Freq] or tidal volume [V T]) and of normal minute ventilation prolonged to 12-fold duration, synchronously at biophysical, biochemical/cellular, histological, and transcriptional levels in a model of mild lung injury. " 06/15/2005 - "In this review we focus on experimental evidence for lung cells as injury targets and the relevance of these studies for human ventilator-associated lung injury. " Order ALL the reference details at left...
3.	Cardiopulmonary Bypass (Heart-Lung Bypass) 06/01/2007 - "Because lipopolysaccharide preconditioning is a systemic phenomenon offering proven protection against myocardial, hepatic, and pulmonary injury, this technique offers enormous potential for protecting against systemic neonatal injury related to cardiopulmonary bypass." 02/01/2000 - "CONCLUSIONS: Our study demonstrates that arrested pulmonary circulation during cardiopulmonary bypass is the major risk factor of lung injury and that continuous pulmonary perfusion is effective in preventing lung injury." 06/01/1999 - "CONCLUSIONS: These data suggest that liquid lung ventilation dosing at full functional residual capacity before bypass is more effective than half functional residual capacity in minimizing the lung injury associated with neonatal cardiopulmonary bypass. " 05/01/1990 - "Leukocyte depletion ameliorates free radical-mediated lung injury after cardiopulmonary bypass." 07/01/1978 - "New Zealand white rabbits were employed in the laboratory to evaluate the efficacy of temporary cardiopulmonary bypass in the prevention of pulmonary injury from endotoxin. " Order ALL the reference details at left...
4.	Artificial Respiration (Mechanical Ventilation) 11/01/2009 - "This study highlighted the importance of type and severity of lung injury in determining outcome following mechanical ventilation." 06/01/2009 - "Although the specific mechanism by which mechanical ventilation causes lung injury remains an active area of study, both alveolar overdistension and cyclical airway collapse and recruitment have been suggested as contributing causes. " 04/15/2009 - "These studies provide novel mechanistic information potentially relevant to fetal lung development and to mechanical ventilation-induced lung injury." 03/01/2007 - "We review the latest knowledge on the progression of lung injury by mechanical ventilation and correlate the findings of experimental work with results from clinical studies. " 01/01/2007 - "Mechanical ventilation is a life-saving intervention in the setting of ARDS and ALI, but clinical trials have demonstrated that mechanical ventilation with excessive tidal volumes plays a role in promoting and perpetuating lung injury and leads to excess mortality. " Order ALL the reference details at left...
5.	Resuscitation 05/01/2003 - "Interventions such as antioxidant therapy and hypertonic saline resuscitation have a rational basis for use and have been shown to be effective in a rodent two-hit lung injury model. " 09/01/2009 - "The rat RBC group did not show an expected inflammatory reaction related to a transfusion-induced lung injury, and a clinical relevance concerning this level of transient inflammatory reaction induced by HbVs is not known; however, attention to the early stage of resuscitation in ongoing studies of HbV is required." 07/01/2004 - "These results support earlier studies that indicated the potential application of HS and PTX in shock therapy and the increase in PMN-endothelial cell interaction and lung injury after LR resuscitation." 12/01/2008 - "Reducing lung injury during neonatal resuscitation of preterm infants." 08/01/2008 - "RESULTS: As compared with the T/SS groups, all three T/HS resuscitation regimens were associated with morphologic evidence of gut and lung injury, increased gut permeability, pulmonary leukosequestration, systemic neutrophil activation, and decreased RBC deformability (p < 0.05). " Order ALL the reference details at left...

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