Moringa oleifera alcoholic extract protected stomach from bisphenol A-induced gastric ulcer in rats via its anti-oxidant and anti-inflammatory activities.

Abstract

This study evaluated the protective potentials of Moringa oleifera leaf alcoholic extract (MOLE) against bisphenol A (BPA)-induced stomach ulceration and inflammation in rats. Control rats received olive oil. Second group administered MOLE (200 mg/kg bwt) by oral gavage. Third group was given BPA (50 mg/ kg bwt) for 4 weeks. Fourth group administrated BPA and MOLE simultaneously. Fifth group was given MOLE for 4 weeks then administered BPA and MOLE for another 4 weeks. Bisphenol A induced gastric ulceration and decreased the volume of gastric juice, prostaglandin E2 (PGE2), reduced glutathione (GSH) and interleukin 10 (IL-10) contents, superoxide dismutase (SOD) activity, and proliferating cell nuclear antigen (PCNA) protein in stomach tissues, while increased the titratable acidity, malondialdehyde (MDA), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) contents, and caspase-3 and NF‑κB proteins in stomach tissue. However, MOLE ameliorated BPA-induced gastric ulceration and significantly increased the volume of gastric juice, PGE2, GSH and IL-10 contents, SOD activity, and PCNA protein while significantly decreased titratable acidity, MDA, TNF-α and IL-6 contents, and of NF‑κB and caspase-3 proteins in gastric tissue. This study indicated that MOLE protected stomach against BPA-induced gastric injury via its anti-oxidant, anti-apoptotic, and anti-inflammatory activities.

• Authors: Reda Abo Elfath Ahmed Abo-Elsoud, Seham Ahmed Mohamed Abdelaziz, Mabrouk Attia Abd Eldaim, Suzan Moustafa Hazzaa
• Journal: Environmental science and pollution research international (Environ Sci Pollut Res Int) Vol. 29 Issue 45 Pg. 68830-68841 (Sep 2022) ISSN: 1614-7499 [Electronic] Germany
• PMID: 35554805 (Publication Type: Journal Article)
• Copyright: © 2022. The Author(s).

Chemical References

• Anti-Inflammatory Agents
• Antioxidants
• Benzhydryl Compounds
• Interleukin-6
• NF-kappa B
• Olive Oil
• Phenols
• Plant Extracts
• Proliferating Cell Nuclear Antigen
• Tumor Necrosis Factor-alpha
• Interleukin-10
• Malondialdehyde
• Superoxide Dismutase
• Caspase 3
• Glutathione
• Dinoprostone
• bisphenol A

Topics

• Animals
• Anti-Inflammatory Agents (pharmacology)
• Antioxidants (metabolism)
• Benzhydryl Compounds
• Caspase 3
• Dinoprostone (metabolism, therapeutic use, toxicity)
• Glutathione (metabolism)
• Interleukin-10
• Interleukin-6
• Malondialdehyde (metabolism)
• Moringa oleifera (metabolism)
• NF-kappa B (metabolism)
• Olive Oil
• Phenols
• Plant Extracts (therapeutic use)
• Proliferating Cell Nuclear Antigen (therapeutic use)
• Rats
• Stomach Ulcer (chemically induced, drug therapy)
• Superoxide Dismutase (metabolism)
• Tumor Necrosis Factor-alpha