PM2.5 Exposure and Asthma Development: The Key Role of Oxidative Stress.

Abstract

Oxidative stress is defined as the imbalance between reactive oxygen species (ROS) production and the endogenous antioxidant defense system, leading to cellular damage. Asthma is a common chronic inflammatory airway disease. The presence of asthma tends to increase the production of reactive oxygen species (ROS), and the antioxidant system in the lungs is insufficient to mitigate it. Therefore, asthma can lead to an exacerbation of airway hyperresponsiveness and airway inflammation. PM2.5 exposure increases ROS levels. Meanwhile, the accumulation of ROS will further enhance the oxidative stress response, resulting in DNA, protein, lipid, and other cellular and molecular damage, leading to respiratory diseases. An in-depth study on the relationship between oxidative stress and PM2.5-related asthma is helpful to understand the pathogenesis and progression of the disease and provides a new direction for the treatment of the disease. This paper reviews the research progress of oxidative stress in PM2.5-induced asthma as well as highlights the therapeutic potentials of antioxidant approaches in treatment of asthma.

• Authors: Kaimeng Liu, Shucheng Hua, Lei Song
• Journal: Oxidative medicine and cellular longevity (Oxid Med Cell Longev) Vol. 2022 Pg. 3618806 ( 2022) ISSN: 1942-0994 [Electronic] United States
• PMID: 35419163 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2022 Kaimeng Liu et al.

Chemical References

• Antioxidants
• Particulate Matter
• Reactive Oxygen Species

Topics

• Antioxidants (metabolism)
• Asthma (drug therapy)
• Humans
• Oxidative Stress (physiology)
• Particulate Matter (toxicity)
• Pulmonary Disease, Chronic Obstructive
• Reactive Oxygen Species (metabolism)