Elevated interleukin-37 associated with tophus and pro-inflammatory mediators in Chinese gout patients.

Abstract

INTRODUCTION:

Interleukin-37(IL-37), a natural inhibitor of innate immunity, has been identified to protect against various inflammatory diseases, including monosodium urate (MSU)-induced inflammation. However, the association of IL-37 with clinical indexes and pro-inflammatory mediators in gout patients remains unclear. The aim of this study was to determine IL-37 level in hyperuricemia and gout patients with or without tophus, and to investigate the correlations of IL-37 with clinical indexs such as Uric Acid (UA), CRP(C-reactive protein), Creatinine Clearance Rate (Ccr), Erythrocyte Sedimentation Rate (ESR) and so on, as well as with the pro-inflammatory mediators in serum including Interleukin-1β(IL-1β), Interleukin-6(IL-6) and Interleukin-18(IL-18) from gout patients.

METHODOLOGY:

The serum levels of IL-37, IL-1β, IL-6 and IL-18 levels in serum of gout patients were determined by ELISA; the correlations between IL-37 and clinical values or pro-inflammatory mediators in serum of gout were analyzed by Spearman correlation test.

RESULTS:

The serum levels of IL-37 were higher in active gout patients than inactive gout patients and HCs, especially in active gout patients with tophus. No significant difference was observed in serum IL-37 levels between hyperuricemia and normal controls. IL-1β, IL-6 and IL-18 levels were significant elevated in gout patients with tophus than those without tophus; Serum IL-37 were positively correlated with CRP and ESR, as well as with IL-1β, IL-6 and IL-18, negatively correlated with Ccr, and not correlated with UA, creatinine (Cr) and triglyceride (TG) in gout patients.

CONCLUSIONS:

IL-37 increased in gout patients positively associated CRP and ESR, as well as with proinflammatory mediators IL-1β, IL-6, IL-18, the presence of tophus and chronic kidney disease in gout. It may be a novel marker for predicting this pathology.

• Authors: Liping Ding, Heng Li, Baodong Sun, Tingting Wang, Shuhui Meng, Qin Huang, Xiaoping Hong, Dongzhou Liu
• Journal: Cytokine (Cytokine) Vol. 141 Pg. 155468 (05 2021) ISSN: 1096-0023 [Electronic] England
• PMID: 33647713 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2021 Elsevier Ltd. All rights reserved.

Chemical References

• IL37 protein, human
• Inflammation Mediators
• Interleukin-1

Topics

• Adult
• Aged
• Female
• Gout (blood, diagnostic imaging, immunology)
• Humans
• Inflammation Mediators (blood, immunology)
• Interleukin-1 (blood, immunology)
• Male
• Middle Aged