Gout

03/01/1992 - "This study supports the hypothesis that genetic factors exert an important control on the renal clearance of urate, which determines some of the familiarity of hyperuricaemia and gout."
02/01/2021 - "Our finding shows that it is beneficial in many aspects to use uric-acid-lowering drugs at the initial stage of an acute gout attack. "
01/01/2020 - "Urate-PRS alone did not performed in the gout prediction (area under the receiver operating characteristic curve, AUROC = 0.640); however, the addition of PRS upon demographics significantly improved the model performance, yielding an AUROC of 0.804 from 0.777 (DeLong test p = 3.66e-9). "
01/01/2020 - "There is significant reduction in MAU after the use of urate-lowering drugs in patients with gout."
10/01/2019 - "The finding of genetic pleiotropy indicates the existence of common upstream pathological elements influencing both urate and metabolic traits, and this may suggest new opportunities and challenges for developing drugs targeting a common mediator that would be beneficial for both the treatment of gout and the prevention of cardiovascular comorbidities."

01/01/2022 - "Several observational studies reported that allopurinol, an effective treatment for gout, was associated with important reductions in cardiovascular (CV) events, with calls for large, randomized trials, although some results were conflicting. "
12/01/2018 - "Compared with the control intervention, a higher proportion of those in the educational/behavioral intervention arm were adherent to allopurinol, achieved at least a 2 mg/dl decrease in SU, achieved an SU < 5 mg/dl, had a reduction in the presence of tophi at 2 years, had improved quality of life as assessed with SF-36 physical component scores, had a higher knowledge about gout and higher patient satisfaction (moderate-low quality evidence). "
05/01/2014 - "Gouticin 500 mg twice daily is more effective than the allopurinol 300mg once daily in the management of gout."
03/01/2014 - "Gout is a major health problem in Polynesians and allopurinol, the drug of choice for the management gout, appears to be less effective in Polynesian patients. "
06/01/2022 - "betle can be an effective treatment for gout in broiler chicken, as an alternative to Allopurinol."

03/01/2015 - "In open-label extension studies, 3-5 years' treatment with febuxostat maintained a target sUA level of <6.0 mg/dL in most patients; sustained reduction in sUA level was associated with near elimination of gout flares and improved tophus status. "
09/01/2018 - "Febuxostat is potent and well-tolerated in the management of chronic gout. "
03/01/2016 - "Febuxostat is a suitable pharmacological option for first line treatment of gout, given its established efficacy and safety, documented in a high number of clinical studies and in daily practice."
01/01/2022 - "This is the first reported example and he has shown no side effect till now, while his gout improved of a successful desensitization protocol using a solid preparation of diluted febuxostat given as pills."
01/01/2019 - "Equivalent doses of febuxostat XR and IR had similar treatment effects on serum UA level end points; however, a significantly greater proportion of patients achieved a serum UA level of <5.0 mg/dl with XR 40 mg versus IR 40 mg. Similar proportions of patients experienced ≥1 gout flare across treatment groups. "

12/01/2010 - "Low-dose and high-dose colchicine have comparable efficacy in the treatment of acute gout, but high dose carries significantly greater risk of adverse effects."
10/18/2006 - "Colchicine is regarded as beneficial in the treatment of acute gout, but has a high frequency of gastrointestinal adverse events. "
06/01/2016 - "Considerable inter-patient variability exists in the use of colchicine for acute gout, suggesting the efficacy of low dose regimens be explored. "
08/15/2014 - "Based upon only two published trials, there is low-quality evidence that low-dose colchicine is likely to be an effective treatment for acute gout. "
08/01/2022 - "Colchicine was effective in reducing the incidence of MI in patients with gout. "

01/01/2020 - "Results from patients treated with pegloticase or placebo in two randomized clinical trials and their open-label extension were assessed using a novel evidence-based Gout Multivariable Improvement Measure (GMIM) derived from previously reported criteria for remission and complete response. "
10/20/2014 - "This study showed pegloticase is probably beneficial in the management of tophi in gout, in terms of resolution of tophi, but with a high risk of adverse infusion reactions. "
11/01/2021 - "Moderate-certainty evidence showed that pegloticase is probably beneficial for resolution of tophi in gout. "
09/01/2012 - "Two recent Phase III trials have found pegloticase to be effective in the management of treatment-failure gout. "
11/01/2011 - "For patients with refractory and tophaceous gout, intravenous pegloticase is a new treatment option. "

02/01/2017 - "Of these, xanthine oxidase inhibitors are used first line and are effective in 'curing' gout in the vast majority of patients. "
01/01/2019 - "Integration of Pharmacometrics and Pharmacoeconomics to Quantify the Value of Improved Forgiveness to Nonadherence: A Case Study of Novel Xanthine Oxidase Inhibitors for Gout."
04/01/2014 - "Because we have recently found that two 6-(propan-2-yl)-4-methyl-morpholine-2,5-diones, as novel non-purine xanthine oxidase inhibitors, may give promise to be used in the treatment of gout, in this review we have included a study of molecular interactions of the selected cyclodidepsipeptides with xanthine oxidase using idTarget web server. "
10/05/2023 - "Rapid screening, isolation, and activity evaluation of potential xanthine oxidase inhibitors in Polyporus umbellatus and mechanism of action in the treatment of gout."
09/22/2023 - "The prevalence of gout and the adverse effects of current synthetic anti-gout drugs call for new natural and effective xanthine oxidase (XOD) inhibitors to target this disease. "

12/01/2018 - "Conventional treatments have been effective in treating acute gout flares in most patients, but certain options, like NSAIDs could increase the risk of CAD. "
06/01/2000 - "Pharmacokinetic properties should be taken into account when selecting an NSAID for the treatment of gout, as rapid absorption and a short half-life may help to avoid accumulation in patients with subclinical renal function impairment. "
05/01/2005 - "Selective COX II inhibitors, as well as traditional NSAIDs, are effective in acute gout. "
10/14/2020 - "Correction: Comparative efficacy of traditional non-selective NSAIDs and selective cyclo-oxygenase-2 inhibitors in patients with acute gout: a systematic review and meta-analysis."
10/01/2020 - "To assess the comparative efficacy of traditional non-steroidal anti-inflammatory drugs (NSAIDs) and selective cyclo-oxygenase-2 inhibitors in patients with acute gout. "

02/15/2015 - "Anakinra was effective in most patients (90%), with higher complete clinical response rates for Schnitzler's syndrome, gout, CAPS and AOSD. "
08/01/2017 - "Herein, we report the case of a 69-year-old female who presented with polyarticular tophaceous gout treated successfully with anakinra."
01/02/2019 - "Efficacy of anakinra was shown to be non-inferior to treatment as usual for the treatment of acute gout flares, suggesting that anakinra is an effective treatment alternative for acute gout flares. "
01/01/2022 - "Anakinra was effective and safe for management of gout flares in difficult-to-treat patients. "
12/01/2018 - "Anakinra may be a safe therapeutic option for gout patients with advanced CKD. "

01/01/2019 - "Benzbromarone is a safe and effective molecule for the treatment of gout. "
09/01/2016 - "The safety and efficacy of benzbromarone in gout in Aotearoa New Zealand."
11/21/2021 - "Benzbromarone may reduce CV risk and mortality in patients with gout, although more studies are necessary to confirm our findings and to advance our understanding of the underlying mechanisms."
11/01/2023 - "Moreover, treatment with benzbromarone effectively prevented the further development of gout or tophi formation in model mice. "
01/01/2023 - "The uricosuric drug benzbromarone, widely used for treatment of gout, hyperpolarizes the membrane potential of airway smooth muscle cells, but how it works remains unknown. "

03/01/2008 - "The first group (Group I) included 27 patients taking gout prescription I; the second group (Group II) included 27 patients taking gout prescription II; the third group (Group III) included 28 patients taking gout prescription III; and the fourth group (control group) included 25 patients taking indomethacin and Benzobromarone as a control group. "
11/30/1971 - "[Use of indomethacin in the treatment of gout]."
07/01/1968 - "[Indomethacin in acute gout: report of 95 cases]."
01/01/1963 - "II. INFLUENCE OF NEW ANTI-INFLAMMATORY DRUG, INDOMETHACIN, IN ACUTE GOUT."
01/01/1993 - "It is as safe and effective as indomethacin in the treatment of acute gout, and is particularly useful in patients with contraindications to therapy with nonsteroidal antiinflammatory drugs."

03/01/1985 - "Medical therapy, which is now the cornerstone of treatment for most aspects of gout, may not be the best treatment for tophaceous deposits in the hand. "
05/01/1995 - "On the second hospital day, synovial fluid analysis revealed acute gout, and the patient improved very rapidly on anti-gout therapy. "
11/01/2009 - "Adequate duration of anti-inflammatory therapy and careful patient education are essential elements of successful therapy for acute gout. "
12/01/2017 - "It remains to be seen if this therapy will provide additional benefit for gout management above improved use of widely available generic therapies."
06/01/2015 - "The combination treatment therapy resulted in effective treatment of gout due to degradation of crystals and anti-inflammatory response."

12/01/2014 - "The roots and rhizomes of Smilax riparia, called 'Niu-Wei-Cai' in traditional Chinese medicine, are believed to be effective in treating the symptoms of gout. "
09/15/2014 - "The roots and rhizomes of Smilax riparia (SR), called "Niu-Wei-Cai" in traditional Chinese medicine (TCM), are believed to be effective in treating gout symptoms. "
01/01/2014 - "The roots and rhizomes of Smilax riparia, called "Niu-Wei-Cai" in traditional Chinese medicine (TCM), are believed to be effective in treating gout symptoms. "
11/17/2023 - "The objective of this study was to explore common TCM constitutions among gout patients and investigate the potential relationship between traditional Chinese medicine's (TCM) constitution and clinical parameters. "
01/01/2023 - "Conclusion: In conclusion, this study confirms the effectiveness of QHJR, a modified formulation of SMS (a classic traditional Chinese medicine prescription for treating gout), against AGA. "

01/01/2022 - "Considering that gout is not easily treated and cured, further studies are explored to prevent gout development through diet modification. "
08/01/2020 - "High patient acceptability and feasibility of study/intervention and finalization of key study procedures indicate that hypothesis-testing internet gout trials of cherry extract and/or diet modification can be conducted in the future."
08/01/2020 - "We randomized 84 people with physician-confirmed gout in an internet study to cherry extract (n = 41) or dietitian-assisted diet modification for gout (n = 43). "
08/01/2020 - "Patient-Centered Outcomes and Key Study Procedure Finalization in the Pilot Feasibility Gout Randomized Trial: Comparative Feasibility Study in GOUt, CHerry Extract Versus Diet Modification (Mini-GOUCH)."
06/01/2020 - "The aim of this study was to conduct a 9-month pilot Internet randomized controlled trial (RCT) of cherry extract and diet modification in gout to assess the feasibility of an Internet study and obtain effect estimates. "

01/01/2017 - "For the first time, this study provides a rational basis for the traditional use of SM aqueous extract against gout in folk medicine."
05/15/2011 - "For the first time, this study provides a rational basis for the traditional use of olive leaves against gout in Mediterranean folk medicine."
12/01/2022 - "People throughout the world are strongly dependent on ethnomedicine for the treatment of gout and some receive satisfactory curative treatment. "
01/09/2013 - "(Euphorbiaceae) is a medicinal plant that has been used in South American folk medicine for the treatment of arthritic diseases, particularly gout. "
02/16/2011 - "is widely used in Indian traditional medicine; Ayurveda and Sidha, for treatment of inflammatory disorders and gout. "

01/01/2009 - "For this double-blind placebo-controlled trial patients with the clinical diagnosis of acute gout (n = 381) were referred from primary care centers, but only those patients with crystal-proven gout and absence of contraindications for the trial medication were included (n = 120). "
09/01/2023 - "While existing treatments effectively manage gout in some patients, a significant portion, particularly those with comorbidities, face contraindications to these treatments and require alternative approaches. "
09/01/2017 - "Management of gout flares with presently available agents can be more challenging due to potential nephrotoxicity and/or contraindications in the setting of other common comorbid conditions. "
01/01/2016 - "Careful consideration of comorbidities and contraindications are important when determining the appropriate treatment of patients with gout."
11/01/2012 - "Absolute and relative contraindications to gout medications were evaluated based on product labelling. "