Gout

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2274 relevant articles (128 outcomes, 181 trials/studies) found for this Disease

Description: Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of uric acid calculi.

Also Known As:

Gouts

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hyperuricemia
2.	Arthritis (Polyarthritis)
3.	Pain (Aches)
4.	Osteoarthritis
5.	Ankylosing Spondylitis

Experts

1.	Becker, Michael A: 4 articles (09/2008 - 03/2005)
2.	Sundy, John S: 4 articles (09/2008 - 01/2006)
3.	Dalbeth, Nicola: 4 articles (06/2008 - 08/2006)
4.	Joseph-Ridge, Nancy: 4 articles (06/2008 - 08/2004)
5.	Gow, Peter: 4 articles (01/2007 - 06/2005)
6.	Schumacher, H Ralph: 4 articles (04/2006 - 03/2005)
7.	Terkeltaub, Robert: 3 articles (07/2008 - 10/2006)
8.	MacDonald, Patricia A: 3 articles (06/2008 - 03/2005)
9.	Curhan, Gary: 3 articles (02/2008 - 03/2004)
10.	Choi, Hyon K: 3 articles (02/2008 - 03/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Gout:

1.	Uric Acid (Urate)IBA 07/01/2001 - "In addition, after lead chelating therapy, urate clearance markedly improved after a reduction of the BLS of patients with CRI and gout (study group 67.9 +/- 80.0% vs. control group 1.2 +/- 34.0%, P = 0.0056)" 03/01/1992 - "This study supports the hypothesis that genetic factors exert an important control on the renal clearance of urate, which determines some of the familiarity of hyperuricaemia and gout." 07/01/2000 - "In this study it was investigated whether dietary measures, reported to be beneficial in IR, have serum uric acid (SU) and lipid lowering effects in gout" 06/01/2007 - "Successful management of chronic gout depends on reducing body pools of urate" 01/01/1998 - "Interestingly, no significant rise in the plasma, urinary and clearance of uric acid was observed in gout patients with uric acid clearance > 6.0 mL/min (lower normal limit)" Order ALL the reference details at left...
2.	Allopurinol (Remid)FDA LinkGeneric 03/01/2005 - "Therapy with allopurinol has been effective for those manifestations the disease shares with gout" 09/01/1989 - "We concluded that the intermittent administration of allopurinol as given here is less effective in controlling symptoms of gout than continuous therapy." 06/01/1987 - "Although allopurinol is primarily known as an effective medication for gout, it has been shown to enhance tissue survival in a wide range of ischemic conditions" 01/23/1981 - "Therapeutic efficacy of slow-release allopurinol in gout and hyperuricaemia (author's transl)]" 05/01/2007 - "METHODS: A total of 90 gout patients were randomly assigned to two groups, the control group (45 cases) administrated with Finbid orally in the acute stage and allopurinol in the remission period; and the treatment group (45 cases) treated with the same treatment plus oral administration of JHYD" Order ALL the reference details at left...
3.	Colchicine FDA Link 01/01/2006 - "Colchicine is regarded as beneficial in the treatment of acute gout, but has a high frequency of gastrointestinal adverse events" 04/10/1987 - "Colchicine has the smallest benefit-to-toxicity ratio of drugs that are effective for acute gout" 11/01/1982 - "The efficacy of colchicine prophylaxis in articular gout--a reappraisal after 20 years." 08/01/1961 - "Efficacy of colchicine prophylaxis in gout" 01/01/2006 - "SELECTION CRITERIA: Published randomised controlled trials (RCTs) and controlled clinical trials evaluating symptom relief and adverse outcomes of colchicine therapy in acute gout were considered for this review" Order ALL the reference details at left...
4.	Indomethacin (Indometacin)FDA LinkGeneric 01/01/1983 - "Oxametacin, a new non steroidal anti-inflammatory compound, with analgesic, antipyretic and anti-inflammatory properties comparable to those of indomethacin, has been claimed to be effective in treatment of acute attacks of gout" 01/01/1993 - "It is as safe and effective as indomethacin in the treatment of acute gout, and is particularly useful in patients with contraindications to therapy with nonsteroidal antiinflammatory drugs." 03/01/2008 - "The first group (Group I) included 27 patients taking gout prescription I; the second group (Group II) included 27 patients taking gout prescription II; the third group (Group III) included 28 patients taking gout prescription III; and the fourth group (control group) included 25 patients taking indomethacin and Benzobromarone as a control group" 11/01/2000 - "This case report describes an elderly man, prescribed indomethacin for gout, who presented with psychosis." 11/30/1971 - "Use of indomethacin in the treatment of gout]" Order ALL the reference details at left...
5.	Procetofen (CiL)FDA LinkGeneric 02/01/2003 - "Fenofibrate may be a potential new treatment for hyperuricaemia and the prevention of gout, particularly in patients with coexisting hyperlipidaemia or those resistant to conventional therapy for hyperuricaemia." 10/01/2001 - "Fenofibrate: a new treatment for hyperuricaemia and gout?" 02/01/2003 - "Long-term remission from gout associated with fenofibrate therapy." 06/01/2006 - "METHODS: Fourteen male patients with chronic tophaceous or recurrent acute attacks of gout were evaluated in an open-label pilot study of the hypolipidemic agent, fenofibrate (Lipidil Supra 160 mg/d)" 02/01/2003 - "The mechanisms involved in these effects and the potential role for fenofibrate in the management of gout are discussed." Order ALL the reference details at left...
6.	Naproxen (Naprosyn)FDA LinkGeneric 01/01/1980 - "Effect of naproxen on gout attacks]" 02/01/1977 - "Naproxen is a useful alternative agent for the treatment of acute gout." 01/01/1977 - "Naproxen is a useful alternative agent for the treatment of acute gout." 04/01/1975 - "The treatment of acute gout with naproxen." 02/01/1975 - "In 15 patients with acute gout using naproxen as exclusive therapy, excellent results were observed in nine patients very good in four, and unsatisfactory in only two cases" Order ALL the reference details at left...
7.	febuxostatIBA 01/01/2008 - "Long-term treatment with febuxostat for up to 4 years or more reduced the incidence of gout flares to (or close to) zero" 08/01/2006 - "Febuxostat for prevention of gout attacks." 03/01/2005 - "Gout flares occurred with similar frequency in the placebo (37%) and 40-mg febuxostat (35%) groups and with increased frequency in the higher dosage febuxostat groups (43% taking 80 mg; 55% taking 120 mg)" 08/01/2006 - "4) Given that renal dysfunction is a risk factor for hyperuricemia and gout, the safety and efficacy of febuxostat in this population should be considered, but only limited data are available" 12/01/2006 - "Additional clinical trial evidence supports the efficacy and safety of febuxostat in the treatment of hyperuricemia and gout" Order ALL the reference details at left...
8.	Xanthine OxidaseIBA 02/12/2007 - "Xanthine oxidase inhibitory activity was assayed from six species belonging to different families traditionally used for the treatment of gout and related symptoms by indigenous people of India" 01/01/2004 - "These active constituents were known to have bioactivity against the enzyme xanthine oxidase and potentially could be employed in the treatment of gout" 09/01/2003 - "4. The xanthine oxidase inhibition assay is used to identify potential anti-gout agents" 11/01/2000 - "Inhibition of xanthine oxidase by some Chinese medicinal plants used to treat gout." 02/01/1999 - "Xanthine oxidase (xanthine: oxygen oxidoreductase EC 1.2.3.2) inhibitory activity was assayed from 26 species belonging to 18 families traditionally used for the treatment of gout and related symptoms by Indigenous people of northeastern North America" Order ALL the reference details at left...
9.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 06/01/1990 - "Our preliminary study suggests that a short course of oral corticosteroid therapy can be used effectively for acute gout when NSAIDs are contraindicated" 05/01/2005 - "Selective COX II inhibitors, as well as traditional NSAIDs, are effective in acute gout" 01/01/2004 - "NSAIDs are the preferred treatment in acute gout" 02/16/2002 - "First choice treatment of acute gout consists of NSAIDs" 10/01/1994 - "Nonsteroidal anti-inflammatory drugs (NSAIDs) are now commonly used for the treatment of acute gout, but caution is required in view of their adverse effects, especially in the elderly" Order ALL the reference details at left...
10.	CreatinineIBA 08/01/2008 - "An extended adjustment for BMI, creatinine, gout medication, and alcohol intake improved P values to a range of 10(-14) to 10(-20)" 11/01/2007 - "CONCLUSION: The genotype AA at polymorphism -863C/A in a recessive model showed a significant association with developing gout independent of hyperuricaemia, abnormal creatinine, higher TG, GPT and alcohol consumption." 11/01/2007 - "After adjustment by a stepwise logistic regression method, the hyperuricaemia, creatinine, GPT, TG and alcohol consumption as well as genotype AA at polymorphism -863C/A were found to be significantly associated with gout" 03/01/2001 - "RESULTS: There were no differences between the groups in age, sex, duration of gout, or serum creatinine" 07/01/2000 - "In logistic regression of similar covariates, body mass index (p < 0.0001) and serum creatinine level (p = 0.005) were the strongest determinants of gout; neither bone nor blood lead levels predicted gout in this cohort" Order ALL the reference details at left...

Therapies and Procedures

1.	Transplantation (Transplant Recipients) 06/01/2007 - "Pseudotumor of gout in the patella of a kidney transplant recipient." 08/01/2006 - "METHODS: Patients with post-transplantation gout were identified from the Christchurch Hospital Nephrology database" 08/01/2006 - "AIMS: The aims of the present audit were to determine the prevalence of gout in renal transplant recipients in Canterbury, New Zealand, to identify risk factors for gout, and to assess the range of treatments used, their efficacy and complications" 08/01/2006 - "Gout in renal transplant recipients." 01/01/2005 - "While gout is curable, its pharmacological management in transplant recipients is complicated by the risk of adverse effects and potentially severe interactions between immunosuppressive and hypouricaemic drugs" Order ALL the reference details at left...
2.	Transplants (Transplant) 01/01/2007 - "Spinal gout in a renal transplant patient: a case report and literature review." 09/01/2006 - "Tophaceous gout of the first costochondral junction in a heart transplant patient." 08/01/2006 - "Of those who returned to work post transplant 48% required time off work because of gout" 08/01/2006 - "Of those patients who developed gout post transplant 70% had an attack at least every 3 months" 08/01/2006 - "In addition, the authors wished to assess the impact of post-renal transplant gout on the patient" Order ALL the reference details at left...
3.	Drug Therapy (Chemotherapy) 01/01/2006 - "Although pharmacotherapy is generally safe and effective, there are caveats and limitations to all gout therapies" 06/01/2003 - "Evidence from well-designed clinical studies evaluating drug therapies for gout is limited" 06/01/2003 - "Relevant clinical studies and review articles were found using the text- and keyword-search term gout alone and in combination with epidemiology, prevalence, incidence, complications, outcome, quality of life, economics, cost, prevention or drug therapy" 01/01/2006 - "Management of gout requires characterising and modifying risk factors and associated disorders, and commonly initiating drug therapy" 09/15/1979 - "Modern differential-therapeutic aspects of the drug therapy of chronic gout]" Order ALL the reference details at left...
4.	Kidney Transplantation 01/01/2000 - "The female patients in this study had a lower mean age at onset of gout than in previous studies, which was attributed to the inclusion of renal transplantation patients" 08/01/2006 - "Hypouricaemic therapy should be considered early in those who develop gout post renal transplantation" 11/27/2005 - "New-onset gout after kidney transplantation: incidence, risk factors and implications." 11/27/2001 - "Episodes of gout are common in the setting of renal transplantation" 05/01/1999 - "We reported our observation of 5 patients (3 males and 2 females), 13-18 years old who developed gout 2-84 months after renal transplantation" Order ALL the reference details at left...
5.	Heart Transplantation (Grafting, Heart) 10/01/2000 - "OBJECTIVE: To study the clinical impact of gout treatment following cardiac transplantation" 10/01/2000 - "Post-cardiac transplantation gout: incidence of therapeutic complications." 12/01/1996 - "Treatment of gout following cardiac transplantation." 05/27/2004 - "BACKGROUND: Hyperuricemia and gout are common complications of heart transplantation, reaching a prevalence of 84% and 30%, respectively, in heart transplant recipients" 11/27/2001 - "BACKGROUND: Hyperuricemia is a recognized complication of renal and cardiac transplantation, but the development of hyperuricemia and gout following liver transplantation have received less attention" Order ALL the reference details at left...

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