1α,25-dihydroxyvitamin D3 promotes early osteogenic differentiation of PDLSCs and a 12-year follow-up case of early-onset vitamin D deficiency periodontitis.

Abstract

Periodontitis is a chronic periodontal disease that contributes to tooth loss. In recent years, many animal studies have reported that vitamin D (VitD) deficiency results in chronic periodontitis. However, no studies have reported cases of early-onset periodontitis with VitD deficiency. This study reports a 5-year-old male patient with early-onset periodontitis, VitD deficiency and VitD receptor (VDR) mutation. The patient was treated with VitD and calcium, and received systematic periodontal treatment. During the 12-year treatment, the periodontal conditions of this patient were stable. Our in vitro study found that VitD could promote the expression of alkaline phosphatase (ALP), runt-related transcription factor 2 (Runx2), bone morphogenetic protein 2 (BMP2), bone gamma-carboxyglutamate protein (BGLAP), and VDR in the early osteogenic differentiation of periodontal ligament stem cells (PDLSCs). Meanwhile, VitD could downregulate mRNA expression levels of Interleukin-6 (IL-6), Interleukin-8 (IL-8), Interleukin-1β (IL-1β) and protein levels of IL-6 in the tumor necrosis factor-α (TNF-α) -induced inflammation of PDLSCs. Therefore, sufficient VitD supply can be a potential treatment for VitD deficiency induced early-onset periodontitis.

• Authors: Ganggang Qi, Ke Yu, Yuting Feng, Yanmin Zhang, Qin Shao, Mengjia Yu, Yang Wang, Lingfei Ren, Danji Zhu, Guoli Yang, Zhiwei Jiang
• Journal: The Journal of steroid biochemistry and molecular biology (J Steroid Biochem Mol Biol) Vol. 208 Pg. 105805 (04 2021) ISSN: 1879-1220 [Electronic] England
• PMID: 33486080 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2020 Elsevier Ltd. All rights reserved.

Chemical References

• BGLAP protein, human
• BMP2 protein, human
• Bone Morphogenetic Protein 2
• Core Binding Factor Alpha 1 Subunit
• Receptors, Calcitriol
• Tumor Necrosis Factor-alpha
• VDR protein, human
• Osteocalcin
• Vitamin D
• Calcitriol

Topics

• Adolescent
• Aggressive Periodontitis (drug therapy, genetics, pathology)
• Animals
• Bone Morphogenetic Protein 2 (genetics)
• Calcitriol (administration & dosage)
• Cell Differentiation (drug effects)
• Child
• Child, Preschool
• Core Binding Factor Alpha 1 Subunit (genetics)
• Humans
• Inflammation (drug therapy, genetics)
• Male
• Osteocalcin (genetics)
• Osteogenesis (drug effects)
• Periodontal Ligament (drug effects, growth & development)
• Receptors, Calcitriol (genetics)
• Stem Cells (drug effects)
• Tumor Necrosis Factor-alpha
• Vitamin D (metabolism)
• Vitamin D Deficiency (drug therapy, genetics, pathology)