Periodontal Diseases (Periodontal Disease)

1.	Seymour, G J: 7 articles (06/2008 - 06/2001)
2.	Kocher, T: 5 articles (06/2005 - 08/2000)
3.	Meisel, P: 5 articles (02/2004 - 08/2001)
4.	Giannobile, William V: 4 articles (08/2008 - 01/2003)
5.	Emingil, G: 4 articles (03/2008 - 08/2001)
6.	Atilla, Gül: 4 articles (09/2006 - 08/2005)
7.	Emingil, Gülnur: 4 articles (09/2006 - 08/2005)
8.	Van Dyke, Thomas E: 4 articles (10/2005 - 06/2002)
9.	Breivik, Torbjørn: 4 articles (08/2005 - 11/2003)
10.	Buduneli, Nurcan: 3 articles (07/2008 - 04/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Periodontal Diseases:

1.	Metronidazole (Metric)FDA LinkGeneric 11/01/1986 - "The results showed a significantly greater reduction in the mean probing depth of pockets with the use of metronidazole, but this reduction was apparent only in subjects with severe periodontal disease (PI = 4.0-6.0)" 10/01/1990 - "In the present study, we describe the usefulness of the BANA test at various stages of a clinical trial of the efficacy of metronidazole in the treatment of periodontal disease" 01/01/2004 - "The aim of this study was to evaluate the microbial outcome in patients with recurrent periodontal disease following treatment with 25% metronidazole gel using the polymerase chain reaction (PCR)" 03/01/2003 - "CONCLUSION: This study showed that local treatment with 25% metronidazole gel did not seem to influence the clinical healing in this group of subjects with recurrent periodontal disease." 03/01/2003 - "BACKGROUND: The aim of this study was to evaluate the clinical outcome in patients with recurrent periodontal disease following treatment with 25% metronidazole gel" Order ALL the reference details at left...
2.	Tetracycline (Achromycin)FDA LinkGeneric 01/01/1994 - "These results indicate that use of tetracycline fiber plus SRP clearly reduced the clinical signs of periodontal disease and maintained or improved attachment for up to 24 months in sites previously refractory to treatment." 07/01/1991 - "The safety and efficacy of periodontal disease treatment by intrapocket placement of tetracycline (TC) fibers was investigated in a 60-day multicenter study conducted by selecting 4 sites in each subject with 6-10 mm pockets that bled on probing" 12/01/2001 - "This study examined the creep behavior and oscillatory and flow properties of tetracycline-containing, bioadhesive semisolid formulations, designed for localized treatment of periodontal disease" 11/01/1996 - "PURPOSE: This study examined the mechanical characteristics and release of tetracycline from bioadhesive, semi-solid systems which were designed for the treatment of periodontal diseases" 12/01/1989 - "The purpose of this study was to evaluate the clinical application of strips containing 10% Tetracycline (TC) in periodontal disease" Order ALL the reference details at left...
3.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 04/01/1996 - "However until more data are available, NSAIDs should not be used in the management of chronic periodontal diseases, there being no specific agent(s) or regimen established for use" 01/01/1993 - "In addition to recent advances in the identification and control of etiologic bacteria, investigators have indicated promising results using nonsteroidal antiinflammatory drugs (NSAIDs) as inhibitors of the inflammatory destruction in periodontal disease" 12/01/2003 - "3. NSAIDS show promise in their ability to slow periodontal disease" 01/01/1998 - "The comparative efficacy of nonsteroidal anti-inflammatory agents in the combined treatment of periodontal diseases]" 12/01/1997 - "These studies indicate that NSAIDs have the ability to alter or control the progression of periodontal disease" Order ALL the reference details at left...
4.	TetracyclinesIBA 02/01/2002 - "Other than studies with tetracyclines, this is the first report of beneficial effects of MMPIs in a model of periodontal disease, strongly suggesting that this class of agents could bring therapeutic benefit to patients with this disorder, and that periodontal disease can be used as a model to demonstrate in vivo efficacy of this class of drugs." 01/01/2000 - "This concise review presents with figures, tables, and a comprehensive list of references the many studies which have used the various tetracyclines as LDDS to treat periodontal disease." 01/01/1994 - "Several recent studies have also addressed the therapeutic potential of tetracyclines and CMTs in periodontal disease" 04/01/2004 - "Tetracyclines have been shown to regulate matrix metalloproteinase (MMP) expression in numerous cell types with various periodontal disease models" 05/01/2000 - "Clinical use of tetracyclines in the treatment of periodontal diseases]" Order ALL the reference details at left...
5.	Anti-Bacterial Agents (Antibiotics)IBA 08/01/1993 - "Clinical studies do, however, support the use of antibiotics in the treatment of specific periodontal diseases." 09/22/2008 - "The effects of antibiotics on in vitro biofilm model of periodontal disease." 09/01/2008 - "Systemic antibiotics have been recommended for the treatment of destructive periodontal disease" 09/01/2008 - "Plaque-induced inflammatory periodontal disease affects a significant number of the population, and raises the question as to why antibiotics are not universally used to treat a disease in which bacteria are the main aetiological agent" 02/01/2008 - "OBJECTIVE: The use of antibiotics as an adjunctive therapy in the management of periodontal diseases has always been of interest for dental practitioners" Order ALL the reference details at left...
6.	CollagenIBA 07/01/2000 - "CONCLUSIONS: This study showed great differences in the number of the distinct inflammatory cell subsets according to the severity of the periodontal disease and suggested that activated cytotoxic cells could play a pivotal role in the loss of collagen fibers observed during these pathological states" 06/30/1999 - "Host-modulation of bone-related collagen breakdown has been shown by studies in humans demonstrating that MMP inhibition blocks tissue destruction and release of C-telopeptides in patients with active periodontal disease." 03/01/2007 - "MATERIAL AND METHODS: Thirty patients suffering from advanced periodontal disease, and each of whom displayed one advanced intra-bony defect were randomly treated with a combination of either NBM+PRP+collagen membrane (GTR) or NBM+GTR" 08/01/2005 - "Structural organization of collagen may also be important for the defense against periodontal disease, because in certain conditions abnormal collagen fibrils associate with increased susceptibility to periodontal disease" 06/01/2003 - "Elevated levels of collagen cross-link residues in gingival tissues and crevicular fluid of teeth with periodontal disease." Order ALL the reference details at left...
7.	FluoridesIBA 01/01/2002 - "To address this issue, the study was conducted to assess severity of periodontal disease among (n = 283) 36-45 years old adults residing in area of different concentration of fluoride in drinking water" 04/01/2007 - "It goes a long way to reason out fluoride as an important etiological agent in periodontal disease." 04/01/2007 - "CONCLUSION: The results suggest that there is a strong association of occurrence of periodontal disease in high-fluoride areas" 03/01/2000 - "Despite the use of fluoride, a critical element in the prevention of periodontal disease, many children and adults still suffer needlessly from this "silent" destroyer of the gum tissue and its underlying bone structures" 06/01/1995 - "Statistically significant effects on caries prevalence were seen for country and fluoride grouping; for periodontal disease, significant effects were noted for country, fluoride group and environment" Order ALL the reference details at left...
8.	Interferon Type II (Interferon, gamma)IBA 11/01/2003 - "The purpose of this study was to investigate the associations between gingival crevicular fluid interferon gamma (GCF IFN-gamma) and clinical measures of periodontal disease in HIV+ individuals" 06/01/2005 - "In contrast to the inhibitory effect of gamma interferon (IFN-gamma) on RANKL-mediated osteoclastogenesis reported recently, alternative new evidence is demonstrated via studies of experimental periodontitis using humanized NOD/SCID and diabetic NOD mice and clinical human T-cell isolates from diseased periodontal tissues, where the presence of increasing IFN-gamma is clearly associated with (i) enhanced Actinobacillus actinomycetemcomitans-specific RANKL-expressing CD4(+) Th cell-mediated alveolar bone loss during the progression of periodontal disease and (ii) a concomitant and significantly increased coexpression of IFN-gamma in RANKL(+) CD4(+) Th cells" 08/01/2002 - "In contrast, SHAM treatment caused high plasma interferon-gamma cytokine levels and protective effects in periodontal disease" 02/01/2008 - "RESULTS: Our results showed no significant difference in the allele and genotype frequencies of interleukin-4 (C-590T) and interferon-gamma (G5644A) gene polymorphisms between patients with periodontal disease and controls" 04/01/1992 - "A group of factors which are negative regulators of inflammation including TGF-beta, gamma-interferon, and IL-1 receptor antagonist provide potential for assessment of periodontal disease in remission or in the healing phase" Order ALL the reference details at left...
9.	Minocycline (Cyclops)FDA LinkGeneric 09/01/1982 - "The purpose of this investigation was to determine the efficacy of minocycline hydrochloride in the management of subgingival microorganisms and periodontal disease" 10/01/2004 - "A post-marketing study of 2805 patients treated for periodontal disease with Arestin." 05/01/1995 - "The aim of the present study was to compare total numbers of cultivable bacteria and prevalence of resistance to minocycline among periodontal bacteria following subgingival or systemic application of minocycline in patients suffering from periodontal disease" 06/01/1991 - "The current concept of crevicular minocycline therapy for periodontal disease." 09/01/1982 - "The data indicated that minocycline may be a useful adjunct in the treatment of periodontal disease" Order ALL the reference details at left...
10.	Anti-Infective Agents (Microbicides)IBA 03/01/1996 - "Likely, we have barely scratched the surface in studying the efficacy of locally delivery antimicrobial agents to alter the progression of periodontal disease" 01/01/1988 - "Although numerous studies with different antimicrobial agents have been published it is still controversial if antimicrobials agents have a role in the treatment of human periodontal diseases" 03/20/2002 - "Local delivery systems of antimicrobial agents for treatment of the periodontal diseases received considerable attention during the past decade due to the disadvantages of the systemic administration" 08/01/2000 - "This also appears to be the first report in which clinical and microbiological responses to commonly used antimicrobial agents for periodontal disease in cats has been documented and quantified" 07/01/2000 - "Local delivery of antimicrobial agents for the treatment of periodontal diseases." Order ALL the reference details at left...

Therapies and Procedures

1.	Oral Hygiene (Dental Hygiene) 05/01/1980 - "With an optimal level of oral hygiene, periodontal disease can be cured and further destruction of the periodontal tissues avoided irrespective of the surgical technique utilized for pocket elimination" 02/01/2000 - "Periodontal disease prevalence was high but would respond to improved oral hygiene" 06/01/1998 - "Improved diagnostics based on more precise periodontal disease classification, simplification of mechanical oral hygiene equipment and procedures, and the development of conventional and non-conventional chemical and physical adjuncts may be expected to reduce the rate of common periodontal disease advance, resulting in less complex treatments, and more of the latter coming to lie within the competence of the generalist and the hygienist working together" 02/01/1998 - "The son also had palmar plantar hyperkeratosis, but despite the fact that he initially harboured Actinobacillus actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis, he did not develop periodontal disease over a seven-year observation period when improved oral hygiene and professional tooth cleaning were instituted." 11/01/2006 - "The aim of the present study was twofold: first, to determine whether oral malodour and periodontal disease parameters are associated with one another in 150 Turkish subjects (mean age +/- SD = 9.1 +/- 2.7 years; age range = 7-12 years); and secondly, to investigate the impact of oral hygiene instruction and scaling on oral malodour" Order ALL the reference details at left...
2.	Root Planing 12/01/2003 - "BACKGROUND: Although mechanical non-surgical therapy (scaling and root planing) is the most common means of initial treatment of periodontal diseases, the relative clinical efficacy of various methods, including manual versus machine-driven, with or without adjunctive agents, has not been determined" 11/01/1991 - "By common methods like scaling and root planing, flap procedures or surgical furcation treatment, a successful therapy of periodontal disease is possible in about 90% of the cases" 01/01/2000 - "This study indicates that smokers have different treatment response patterns and healing dynamics compared to non-smokers following scaling and root planing, suggesting that for smoking patients a more intensive treatment regimen is needed for a better treatment outcome and reduced risk for further periodontal disease progression." 11/01/1984 - "This study was undertaken in order to evaluate the effect of root planing as compared to that of surgical periodontal treatment in patients with advanced periodontal disease" 03/01/2008 - "These results expand the usefulness of SDD therapy as an adjunct to scaling and root planing in the long-term management of periodontal disease." Order ALL the reference details at left...
3.	Drug Therapy (Chemotherapy) 04/01/1996 - "Chemotherapy has an important place in the management of chronic periodontal diseases but routine use must be considered as an over prescription of these valuable agents." 03/01/1997 - "The approval of pharmaceutical products for the treatment and/or prevention of periodontal diseases requires presentation of evidence that supports the safety and efficacy of the particular drug therapy in question" 09/01/1987 - "This study characterized the subgingival microbial flora associated with 27 acute exacerbations of preexistent periodontal disease in 24 patients with chemotherapy-induced myelosuppression" 11/01/2005 - "Treatment of periodontal disease: Part VI. Concepts of periodontal drug therapy]" 01/01/1997 - "The recent explosion in local, less invasive chemotherapies for periodontal disease management has aimed at addressing the site-specific nature of this group of diseases, but the true benefits of such novel therapies cannot be realised until more accurate and specific diagnostic techniques become available" Order ALL the reference details at left...
4.	Ligation 12/01/1994 - "Positive results in these two models--the dog with natural periodontal disease and the non-human primate with ligature-induced attachment loss--justify human clinical trial testing of a putative regenerative therapy." 08/01/2008 - "The aim of this study was to analyze structural changes in the rat gingival epithelium and connective tissue in response to the experimental periodontal disease induced by the ligature technique, under the influence of diabetes" 01/01/2007 - "The aim of the present study was to determine the role of chronic stress in the pathogenesis of ligature-induced periodontal disease in rats" 10/01/2003 - "The aim of this investigation was to study the impact of stress on ligature-induced periodontal disease in rats by means of a variable moderate chronic stress model" 01/01/2003 - "In this study, ligature-induced periodontal disease did not promote changes during pregnancy that resulted in low birth weight in newborn Wistar rats." Order ALL the reference details at left...
5.	Debridement 02/01/2005 - "Management of the periodontal microbiota with antibiotic drugs and antiseptic agents in conjunction with mechanical debridement seems to be more effective than mechanical therapy alone, at least in the treatment of advanced periodontal disease" 02/01/1997 - "For example, effective therapy might require a combination of periodontal disease treatment, correction of dental restoration-based food traps and a rigorous daily mechanical debridement of the tongue" 01/01/1994 - "A modified technique aimed at the conservation of maxillary anterior esthetics is proposed for the surgical treatment of periodontal disease when surgery is indicated in addition to nonsurgical debridement" 05/01/1993 - "The effect of subgingival debridement on periodontal disease parameters and the subgingival microbiota." 07/01/1990 - "The response to the treatment and periodontal maintenance during a period of 24 month, was investigated in 17 patients with periodontal disease by comparing root debridement alone versus root debridement plus surgery, in the molar flat surfaces sites" Order ALL the reference details at left...

Best Treatments:
Research Summary Report
on Periodontal Diseases

CureHunter Patient-Physician Summary Reports collect in one document all the medications ever reported in the US National Library of Medicine—1949 to the present—to be effective against your target disease. CureHunter research summary reports will vary in length from 25 to 250 pages. Analytic charts allow you and your physicians to see at a glance your medication options—including new, promising, off-label and experimental all rated for clinical efficacy.

Free Updates for 1 Year
All 93 Outcomes
Top 200 Key Drugs and Biologics
Top 50 Key Therapies and Procedures
Detailed History Charts
Full Research Reference Details
Sample PDF Report on Psoriasis >>

Price:

$24.00 & Delivery via PDF download
updates for 1 year

Research Interface

Rapidly retrieve summaries of all the evidence for any disease in seconds. Save hours of search and analysis time. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time.

Unlimited Disease, Drug and Therapy Search
2 clicks from Disease to Drug to Evidence
Trial References
All the Positive Outcomes
Detailed Relationship Timeline Charts
Full Article Reference Details
Includes Mobile Interface Subscription
One-click to FDA Products/Patents
Request Institution License Details >>

Price:

$490.00 access via web interface
1 year subscription

Proceed to Checkout >>

Mobile Interface

Retrieve summaries of all the evidence for any disease from your Mobile Phone or PDA. Accelerate decision making in the field. Speed up your study of new drug and disease domains. Refresh your knowledge on the road.

Access from any web enabled PDA or Phone
Trial references
All the Positive Outcomes
Drug and Therapy searches
Full Article Reference Details
Try Mobile Interface >>

Price:

$45.00 access via "curehunter.com/m"
1 year subscription

Proceed to Checkout >>