Abstract | OBJECTIVES: METHODS: RESULTS: MVP levels were higher in RA and ERA, compared to OA and healthy controls (p<0.00001). A combination of MVP with RF or anti-CCP showed an improved diagnostic accuracy compared to RF or anti-CCP alone in RA and ERA. MVP exhibited similar AUC levels to anti-CCP and RF in RA whereas in ERA, MVP exhibited the same or slightly higher AUC levels, compared to anti-CCP and RF, respectively. High MVP levels were associated with lack of response to treatment. Levels of anti-MVP peptide 2 antibodies were significantly higher in RA compared to healthy controls (t= 2.73, p=0.007). CONCLUSIONS:
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Authors | Dionysia Marinou, Gikas Katsifis, Georgia Barouta, Christos Liaskos, Lazaros I Sakkas, Athanasios Tsakris, John G Routsias |
Journal | Clinical and experimental rheumatology
(Clin Exp Rheumatol)
2021 Sep-Oct
Vol. 39
Issue 5
Pg. 1033-1042
ISSN: 0392-856X [Print] Italy |
PMID | 33124564
(Publication Type: Journal Article)
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Chemical References |
- Autoantibodies
- Biomarkers
- Peptides, Cyclic
- Vault Ribonucleoprotein Particles
- major vault protein
- Rheumatoid Factor
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Topics |
- Arthritis, Rheumatoid
(diagnosis)
- Autoantibodies
- Biomarkers
- Enzyme-Linked Immunosorbent Assay
- Humans
- Lung
- Peptides, Cyclic
- Rheumatoid Factor
- Vault Ribonucleoprotein Particles
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