Brain-derived neurotrophic factor and mental disorders.

Abstract

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that modulates neuroplasticity in the brain, and is one of the most widely investigated molecule in psychiatric disorders. The researches of BDNF emcompassed the advance of investigative techniques of past decades. BDNF researches ranged from protein quantilization, to RNA expression measurements, to DNA sequencing, and lately but not lastly, epigenetic studies. In this review, we will briefly address findings on BDNF protein levels, mRNA expression, Val66Met polymorphism, and epigenetic modifications, in schizophrenia, major depressive disorder (MDD), and bipolar disorder.

• Authors: Chin-Chuen Lin, Tiao-Lai Huang
• Journal: Biomedical journal (Biomed J) Vol. 43 Issue 2 Pg. 134-142 (04 2020) ISSN: 2320-2890 [Electronic] United States
• PMID: 32386841 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2020 Chang Gung University. Published by Elsevier B.V. All rights reserved.

Chemical References

• Brain-Derived Neurotrophic Factor

Topics

• Bipolar Disorder (genetics, metabolism)
• Brain-Derived Neurotrophic Factor (genetics, metabolism)
• Depressive Disorder, Major (genetics, metabolism)
• Genotype
• Humans
• Polymorphism, Single Nucleotide (genetics)
• Schizophrenia (genetics, metabolism)