Abstract | OBJECTIVE: METHODS: RESULTS: Among multiple serological biomarkers of collagen turnover, the mean level of C5M was higher in SSc (3.9 ng/mL) than healthy subjects (2.6 ng/mL). In addition, PRO-C6 (12.6 ng/mL vs 5.4 ng/mL) and C6M (26.0 ng/mL vs 16.7 ng/mL) were higher in SSc than the controls. The modified Rodnan skin score correlated with PRO-C3 and PRO-C6. Serum level of C6M was higher in patients with ILD. Furthermore, serum levels of PRO-C3, PRO-C6, and C6M were higher in patients with PAH. The use of high levels of these biomarkers as risk factors of PAH showed that all patients with PAH had high levels of risk factors. Of note, two-third of patients with serum PRO-C3, PRO-C6 and C6M values above the respective cut-off values had PAH. CONCLUSION:
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Authors | Satoshi Kubo, Anne Sofie Siebuhr, Anne-C Bay-Jensen, Pernille Juhl, Morten A Karsdal, Yurie Satoh, Yasuyuki Todoroki, Kazuhisa Nakano, Shingo Nakayamada, Yoshiya Tanaka |
Journal | International journal of rheumatic diseases
(Int J Rheum Dis)
Vol. 23
Issue 4
Pg. 532-539
(Apr 2020)
ISSN: 1756-185X [Electronic] England |
PMID | 32022479
(Publication Type: Journal Article)
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Copyright | © 2020 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd. |
Chemical References |
- Biomarkers
- Peptide Fragments
- Collagen
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Topics |
- Adult
- Aged
- Biomarkers
(blood)
- Case-Control Studies
- Collagen
(blood)
- Female
- Humans
- Male
- Middle Aged
- Peptide Fragments
(blood)
- Proteolysis
- Pulmonary Arterial Hypertension
(blood, diagnosis, etiology)
- Pulmonary Fibrosis
(blood, diagnosis, etiology)
- Scleroderma, Systemic
(blood, complications, diagnosis)
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