Collagen Type II (Type II Collagen)

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1662 relevant articles (69 outcomes, 163 trials/studies) found for this Bio-Agent

Description: A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.

Also Known As:

Type II Collagen; Collagen Type II, alpha1 Chain; Collagen Type II, alpha1 Subunit; Collagen alpha1(II); Procollagen Type II; Type II Procollagen; Collagen, Type II; II Procollagen, Type; Procollagen, Type II

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Bio-Agent Context: Research Results

Experts

1.	Holmdahl, Rikard: 17 articles (01/2008 - 05/2002)
2.	Nandakumar, Kutty Selva: 8 articles (01/2008 - 09/2002)
3.	Poole, A R: 7 articles (05/2008 - 05/2000)
4.	Min, So-Youn: 7 articles (04/2008 - 04/2002)
5.	Kim, Ho-Youn: 7 articles (04/2008 - 04/2002)
6.	Ionescu, M: 6 articles (05/2008 - 05/2000)
7.	Cho, Mi-La: 5 articles (04/2008 - 03/2004)
8.	Burkhardt, Harald: 5 articles (01/2008 - 09/2002)
9.	Poole, A Robin: 5 articles (09/2007 - 11/2003)
10.	Bäcklund, Johan: 5 articles (08/2007 - 06/2002)

Related Diseases

1.	Arthritis (Polyarthritis) 08/01/2006 - "In the type II collagen-induced arthritis model, we observed a significant reduction in clinical scores (p < 0.01) in three independent experiments and diminished joint pathology (p < 0.005) in PKC-theta-deficient compared with wild-type littermates. " 01/01/2000 - "Compound 19a (ED40 = 3.6 mg/kg in established AA) possessed good therapeutic efficacy against type II collagen-induced arthritis in DBA/1J mice with doses of 30 and 100 mg/kg, suggesting the development of 19a (designated T-614) as a prospective disease-modifying antirheumatic agent. " 06/01/1985 - "Despite no difference in clearance of anti-type II collagen antibody after transfer between them, the passively transferred arthritis in rnu/rnu rats was significantly enhanced and prolonged in comparison with that in rnu/+ rats. " 07/25/2002 - "CONCLUSION: Gene therapy of IL-ira via non-virus eukaryotic expression vactor, especially by gene gun, is effective in treating arthritis induced by type II collagen." 03/01/2006 - "In this study, water extract of deer antler extract (DAA) prepared from the growing antler of Cervus korean TEMMINCK var. mantchuricus Swinhoe was used to investigate the efficacy of the DAA on the development of type II collagen (CII)-induced arthritis (CIA) in rats. " Order ALL the reference details at left...
2.	Rheumatoid Arthritis 01/17/2006 - "Chicken type II procollagen (ccol2a1) has become as an important oral tolerance protein for effective treatment of rheumatoid arthritis. " 03/01/1998 - "Although effective in animal models, attempts to treat rheumatoid arthritis with orally administered type II collagen have proven elusive. " 10/01/1998 - "OBJECTIVE: Based on the results of two recently published, randomized, double-blind and placebo-controlled studies, a possible improvement in rheumatoid arthritis disease activity after oral tolerization with triple helical collagen type II has been suggested. " 09/01/2000 - "OBJECTIVE: To evaluate the efficacy of oral chicken type II collagen (CII) in the treatment of rheumatoid arthritis (RA). " 06/01/1999 - "OBJECTIVE: To investigate the efficacy of oral type II collagen (CII) in the treatment of rheumatoid arthritis (RA), when added to existing therapy. " Order ALL the reference details at left...
3.	Experimental Arthritis 07/10/1996 - "We then tested aerosolization of a different autoantigen in a different disease model and found that aerosolization of type II collagen was effective in suppressing collagen-induced arthritis. " 04/01/2008 - "Oestrogen exhibits type II collagen protective effects and attenuates collagen-induced arthritis in rats." 12/01/1989 - "Identification of an immunosuppressive epitope of type II collagen that confers protection against collagen-induced arthritis." 08/01/1988 - "We have previously shown that DBA/1 mice immunized with heterologous type II collagen showed remission of the subsequent collagen-induced arthritis (CIA) when pregnant, but experienced exacerbation postpartum. " 03/01/2006 - "This study was conducted to better understand the differential role played by each Peyer's patch DC subset in the induction of oral tolerance to type II collagen (CII) in murine collagen-induced arthritis (CIA). " Order ALL the reference details at left...
4.	Osteoarthritis 01/01/2009 - "Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial." 02/01/2005 - "OBJECTIVE: The objective of this study was to determine whether collagen type II breakdown products in synovial fluid (SF), detected by an enzyme-linked immunoassay, represent a useful marker for early events in osteoarthritis (OA) in the rabbit medial meniscectomy model. " 11/01/1999 - "OBJECTIVE: This study employed immunohistochemistry to investigate the pattern of type II collagen (CII) degradation in an acute injury model of osteoarthritis. " 08/01/1991 - "Additionally, the application of techniques of molecular biology to the study of the genetics of familial osteoarthritis has identified hereditary defects in type II collagen that appear to predispose to the early development of osteoarthritis in affected family members. " 08/15/2009 - "We have previously demonstrated that Smurf2 is highly expressed in human osteoarthritis (OA) tissue, and overexpression of Smurf2 under the control of the type II collagen promoter (Col2a1) induces an OA-like phenotype in aged Col2a1-Smurf2 transgenic mice, suggesting that Smurf2 is located upstream of a signal cascade which initiates OA development. " Order ALL the reference details at left...
5.	Inflammation 07/01/2008 - "RESULTS: In serial observations of tissue pathology, we could note the inflammation of synovium developing a week after the injection of type II collagen. " 05/01/2008 - "casei suppresses the type II collagen-reactive effector function of Th1-type cellular and humoral immune responses in arthritic inflammation." 02/01/2007 - "A type II-collagen derived peptide and its nitrated form as new markers of inflammation and cartilage degradation in equine osteochondral lesions." 11/01/2004 - "Upon immunization with type II collagen, DBA/1 mice develop severe articular inflammation and destruction. " 06/01/2003 - "Here we report that the neonatal injection of bovine type-II collagen (bCII) to ICR (CD-2) mice triggers the development of autoimmune chronic joint inflammation. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Immunoglobulin G (IgG)
2.	Antibodies
3.	Collagen Type I (Type I Collagen)
4.	Collagen
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Interleukin-10 (Interleukin 10)
7.	Interleukin-1 (Interleukin 1)
8.	Chondroitin Sulfates (Chondroitin Sulfate)
9.	Antigens
10.	Biological Markers (Surrogate Marker)

Related Therapies and Procedures

1.	Oral Administration
2.	Intra-Articular Injections
3.	Intranasal Administration
4.	Transplants (Transplant)
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow)

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