Association of herpes zoster and chronic inflammatory skin disease in US inpatients.

Abstract

BACKGROUND:

Patients with chronic inflammatory skin disease (CISD) have potential risk factors for herpes zoster (HZ). However, little is known about HZ risk in CISD.

OBJECTIVE:

To determine whether CISD is associated with HZ.

METHODS:

Data were analyzed from the 2002 to 2012 Nationwide Inpatient Sample, a representative cohort of US hospitalizations (N = 68,088,221 children and adults).

RESULTS:

In multivariable logistic regression models including age, sex, race/ethnicity, insurance, household income, and long-term systemic corticosteroid use, hospitalization for HZ was associated with atopic dermatitis (adjusted odds ratio [95% confidence interval], 1.38 [1.14-1.68]), psoriasis (4.78 [2.83-8.08]), pemphigus (1.77 [1.01-3.12]), bullous pemphigoid (1.77 [1.01-3.12]), mycosis fungoides (3.79 [2.55-5.65]), dermatomyositis (7.31 [5.27-10.12]), systemic sclerosis (1.92 [1.47-2.53]), cutaneous lupus erythematosus (1.94 [1.10-3.44]), vitiligo (2.00 [1.04-3.85]), and sarcoidosis (1.52 [1.22-1.90]). Only lichen planus (crude odds ratio [95% confidence interval], 3.01 [1.36-6.67]), Sézary syndrome (12.14 [5.20-28.31]), morphea (2.74 [1.36-5.51]), and pyoderma gangrenosum (2.44 [1.16-5.13]) showed increased odds in bivariable models. Sensitivity analyses among those younger than 60 and younger than 50 years showed similar results. Predictors of HZ in CISD included female sex, fewer chronic conditions, and long-term systemic corticosteroid use.

LIMITATIONS:

Cross-sectional study.

CONCLUSIONS:

Many CISDs are associated with increased hospitalization for HZ, even below the ages recommended for HZ vaccination. Additional studies are needed to establish CISD-specific vaccination guidelines.

• Authors: Raj Chovatiya, Jonathan I Silverberg
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 85 Issue 6 Pg. 1437-1445 (12 2021) ISSN: 1097-6787 [Electronic] United States
• PMID: 31958523 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

Topics

• Adolescent
• Adult
• Aged
• Child
• Child, Preschool
• Chronic Disease
• Cross-Sectional Studies
• Dermatitis (epidemiology, immunology)
• Dermatitis, Atopic (epidemiology, immunology)
• Female
• Herpes Zoster (epidemiology)
• Hospitalization (statistics & numerical data)
• Humans
• Infant
• Infant, Newborn
• Inpatients
• Middle Aged
• Skin Diseases (epidemiology, immunology)
• Young Adult