Bullous Pemphigoid (Pemphigoid)

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1909 relevant articles (58 outcomes, 179 trials/studies) found for this Disease

Description: A chronic and relatively benign subepidermal blistering disease usually of the elderly and without histopathologic acantholysis.

Also Known As:

Pemphigoid; Pemphigoid, Bullous; Pemphigoids

Relationship Network

Disease Context: Research Results

Skin and Connective Tissue Diseases

Skin Diseases: 6180

Vesiculobullous Skin Diseases: 223

Bullous Pemphigoid: 1909

Immune System Diseases: 1316

Autoimmune Diseases: 12431

Bullous Pemphigoid: 1909

Related Diseases

1.	Pemphigus (Pemphigus Vulgaris)
2.	Bullous Pemphigoid (Pemphigoid)
3.	Blister (Bulla)
4.	Dermatitis Herpetiformis (Disease, Duhring's)
5.	Psoriasis (Pustulosis Palmaris et Plantaris)

Experts

1.	Zillikens, Detlef: 16 articles (12/2007 - 01/2002)
2.	Hashimoto, Takashi: 12 articles (05/2008 - 04/2003)
3.	Sitaru, Cassian: 12 articles (09/2007 - 01/2002)
4.	Zillikens, D: 11 articles (09/2005 - 02/2000)
5.	Hashimoto, T: 10 articles (11/2007 - 01/2000)
6.	Ahmed, A R: 9 articles (11/2007 - 07/2000)
7.	Schmidt, Enno: 9 articles (09/2007 - 01/2002)
8.	Bröcker, E B: 9 articles (09/2005 - 02/2000)
9.	Borradori, L: 7 articles (03/2005 - 05/2000)
10.	Bröcker, Eva-B: 6 articles (11/2006 - 01/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Bullous Pemphigoid:

1.	AutoantibodiesIBA 10/01/1985 - "The highly specific binding of bullous pemphigoid autoantibodies to the hemidesmosome may prove helpful in future biochemical and immunocytochemical studies of this organelle." 10/01/2006 - "By contrast, the titres of autoantibodies against BP180 in the serum and saliva of bullous pemphigoid patients were not statistically related, and further study of the usefulness of the BP180 ELISA for saliva in this disease is needed. " 01/01/1996 - "In an earlier study, the circulating autoantibodies in patients with bullous pemphigoid (BP) were demonstrated in higher frequencies by means of an immunoblot technique then via indirect immunofluorescence. " 06/01/1993 - "The purpose of the present study was to determine whether tissue-bound anti-basement membrane zone (BMZ) autoantibodies in patients with bullous pemphigoid (BP) express a cross-reactive idiotype. " 09/01/2009 - "Evaluation of a new ELISA assay for detection of BP230 autoantibodies in bullous pemphigoid." Order ALL the reference details at left...
2.	Adrenal Cortex Hormones (Corticosteroids)IBA 03/01/2004 - "OBJECTIVE: To evaluate the efficacy of potent class I topical corticosteroids in relation to the affected body surface area (BSA) in patients with bullous pemphigoid and to review the literature. " 05/01/2009 - "BACKGROUND: Since high doses of superpotent topical corticosteroids (CS) have been shown to improve the survival of bullous pemphigoid (BP) patients and to be more effective than oral CS, few studies have described the long-term course of the disease of these patients. " 06/01/2009 - "Histopathological, immunological and serological data confirmed the diagnosis of localized bullous pemphigoid (BP) and treatment with systemic and local corticosteroids led to a sustained remission. " 03/01/2004 - "A dozen reports were published regarding the efficacy of topical corticosteroids in the treatment of bullous pemphigoid. " 01/01/2004 - "In spite of the introduction of systemic corticosteroids, the mortality rates in bullous pemphigoid have generally not improved and vary between 0% and 40%. " Order ALL the reference details at left...
3.	SteroidsIBA 01/01/2005 - "AUTHORS' CONCLUSIONS: Very potent topical steroids are effective and safe treatments for bullous pemphigoid; their use in extensive disease may be limited by side effects and practical factors. " 01/01/2003 - "REVIEWER'S CONCLUSIONS: Very potent topical steroids are effective and safe treatments for bullous pemphigoid; their use in extensive disease may be limited by side effects and practical factors. " 12/01/1989 - "It has been stated that high doses of steroids and immunosuppressive drugs are indicated for the cicatricial, as opposed to juvenile, bullous pemphigoid. " 12/01/1970 - "Complication of high dosage steroids in bullous pemphigoid." 01/01/1993 - "BACKGROUND: Although bullous pemphigoid (BP) is a benign self-limited disease, the mainstay of treatment remains systemic steroids, often in combination with immunosuppressive agents. " Order ALL the reference details at left...
4.	mycophenolate mofetil (Cellcept)FDA LinkGeneric 09/01/1998 - "Successful therapy for bullous pemphigoid with mycophenolate mofetil." 09/01/2009 - "This patient was treated by mycophenolate mofetil for a bullous pemphigoid resistant to corticotherapy." 02/01/2008 - "CONCLUSIONS: Mycophenolate mofetil seems to be an effective and well-tolerated immunosuppressant for moderately active ocular mucous membrane pemphigoid. " 02/01/2008 - "PURPOSE: To evaluate the effectiveness and toxicity of a stepladder immunosuppression strategy, including the use of mycophenolate mofetil and combination therapy, in the treatment of ocular mucous membrane pemphigoid. " 10/01/2001 - "Adjuvant therapy of bullous pemphigoid with mycophenolate mofetil: old drug, new use." Order ALL the reference details at left...
5.	AntigensIBA 06/01/1995 - "We have recently developed a novel immunoblotting system using bacterial fusion protein containing the NC16a domain, the most immunogenic region, of the 180 kD bullous pemphigoid (BP) antigen, which was shown to be highly sensitive and specific method to detect the antigen and to be very useful for the diagnosis of BP. In this study, using this immunoblot assay, we investigated sera obtained from 26 patients who showed atypical clinical features. " 06/01/2004 - "Our data provide further information of the porcine bullous pemphigoid target antigen and may help investigators for their further studies of this disease." 04/01/2004 - "The aim of this study was to analyze the relationship between clinical features of bullous pemphigoid patients and the antigens recognized by their serum. " 11/01/2000 - "The purpose of this study was to clarify the precise in vivo structure of the 180 kDa bullous pemphigoid antigen in normal human skin. " 05/01/1998 - "Immunofluorescence studies showed a markedly reduced expression of the 180-kDa bullous pemphigoid antigen (BP180), and northern analysis of cultured keratinocytes indicated that the gene encoding for BP180 is affected in these GABEB patients." Order ALL the reference details at left...
6.	Azathioprine (Imuran)FDA LinkGeneric 05/01/2006 - "Thus, Cy-A is an useful treatment for ocular chronic autoimmune pemphigoid and eventually azathioprine (50 mg/day) can cheaply replace it although its well-known toxicity." 07/01/1978 - "A controlled trial of azathioprine in the treatment of pemphigoid [proceedings]" 04/01/2000 - "We report a case of a patient with bullous pemphigoid who experienced azathioprine-induced myelosuppression and who was later found to be homozygous for TPMT mutant alleles. " 02/01/1974 - "Azathioprine in the treatment of muco-cutaneous pemphigoid." 01/16/1971 - "Azathioprine in treatment of bullous pemphigoid." Order ALL the reference details at left...
7.	Prednisolone (Predate)FDA LinkGeneric 05/18/1985 - "This study suggests that a combined treatment with moderate doses of prednisolone and 4 large volume plasma exchanges is well tolerated and highly effective in bullous pemphigoid." 04/01/2001 - "The skin lesion of pemphigoid was improved after increasing the prednisolone dose up to 60 mg a day." 03/01/2006 - "He was next diagnosed as suffering from bullous pemphigoid and treated with oral prednisolone, which worsened his condition. " 05/01/2004 - "We studied the precise correlation between ELISA values for BP180 NC16A and the alternations of disease activity in 5 patients with bullous pemphigoid (BP) during various treatments and tried to answer the question of how we can use ELISA to determine the timing of prednisolone (PSL) tapering. " 01/01/1984 - "[Treatment of bullous pemphigoid with prednisolone only: 0.75 mg/kg/day versus 1.25 mg/kg/day. " Order ALL the reference details at left...
8.	Niacinamide (Nicotinamide)FDA Link 04/01/2006 - "These results suggest that nicotinamide, which has been used in humans for the treatment of diabetes and bullous pemphigoid, may hold promise as a preventive therapy of FAS." 08/01/1998 - "This is the first report, to our knowledge, of a case of bullous pemphigoid responding to niacinamide alone." 08/01/1998 - "A case of bullous pemphigoid responding to niacinamide as monotherapy is reported. " 11/01/1991 - "Niacinamide for bullous pemphigoid." 06/01/1994 - "BACKGROUND AND DESIGN: The combination of nicotinamide and tetracycline has been anecdotally reported to be effective in the treatment of bullous pemphigoid. " Order ALL the reference details at left...
9.	Tetracycline (Achromycin)FDA LinkGeneric 01/01/1995 - "Generalized bullous pemphigoid controlled by tetracycline therapy alone." 02/01/1994 - "Treatment of generalized bullous pemphigoid with oral tetracycline." 01/01/1994 - "Treatment of generalized bullous pemphigoid with oral tetracycline." 01/01/1993 - "Treatment of generalized bullous pemphigoid with oral tetracycline." 02/01/1987 - "Two men with nonscarring, persistent, localized bullous pemphigoid, whose eruption is completely controlled with daily doses of oral tetracycline, are described. " Order ALL the reference details at left...
10.	Immunoglobulin G (IgG)IBA 03/01/1999 - "Our data suggest that isotype switching from "inflammatory" IgG1 to "blocking" IgG4 antibody correlates with improvement in bullous pemphigoid." 02/01/2000 - "The direct immunofluorescence (DIF) study showed lineal IgG and C'3 at the dermal epidermal junction which was consistent with the diagnosis of bullous pemphigoid. " 04/01/2009 - "We have shown that binding of bullous pemphigoid (BP)-patient IgG (BP-IgG) causes the internalization of BP180 from the cell membrane. " 11/01/2008 - "Bullous pemphigoid cases demonstrated homogenous DEJ C3d (17/17) whereas C4d was characteristically negative; there was 100% concordance with linear IgG and C3d by DIF. " 06/01/2008 - "RESULTS: IgG from all patients with BP bound intact epidermal basement membrane by indirect immunofluorescence microscopy and immunoblotted bullous pemphigoid antigen-1, -2, or both in HK extracts. " Order ALL the reference details at left...

Therapies and Procedures

1.	Plasma Exchange 09/01/1984 - "41 patients with pemphigoid entered a multicentre randomised study of the efficacy of plasma exchange. " 01/01/1986 - "Long term plasma exchange therapy in bullous pemphigoid." 11/01/1985 - "[Plasma exchange and corticosteroid therapy in the treatment of bullous pemphigoid]" 09/01/1984 - "Plasma exchange in bullous pemphigoid." 09/03/1983 - "[Bullous pemphigoid treated by plasma exchange. " Order ALL the reference details at left...
2.	Plasmapheresis 04/01/2003 - "We report a case of bullous pemphigoid successfully treated with double filtration plasmapheresis. " 12/01/2001 - "Double filtration plasmapheresis for the treatment of bullous pemphigoid: a three case report." 03/01/2001 - "A case of severe bullous pemphigoid treated with plasmapheresis." 03/01/2000 - "Due to its high cost and potential morbidity, plasmapheresis should not be recommended as routine therapy for bullous pemphigoid, but it is a useful adjunct in resistant cases." 03/01/2000 - "Plasmapheresis as a steroid saving procedure in bullous pemphigoid." Order ALL the reference details at left...
3.	Transplantation (Transplant Recipients) 01/01/2009 - "Bullous pemphigoid in a renal transplant recipient: a case report and review of the literature." 05/01/1997 - "After separation of symblepharons in ocular pemphigoid, transplantation of nasal or bucal mucosa is recommended to prevent recurrent lid fusion; however, it is not always successful. " 01/01/2001 - "MATERIALS AND METHODS: 16 patients were treated with amnion membrane transplantation because of: pemphigoid ocularis, combustio chaemica, ulcus corneae, keratopathia bullosa, descemetocele, symblepharon, graft disease. " 10/01/1995 - "METHODS: A total of nine patients (3 with chemical injury, 3 with limbal deficiency with unknown etiology, 2 with moderate ocular pemphigoid [OCP], and 1 with traumatic limbal deficiency) were treated by limbal allograft transplantation. " 10/01/2004 - "Recent developments on mucous membrane pemphigoid surgical therapy include keratolimbal allografts and amniotic membrane transplantation, with or without penetrating keratoplasty for ocular surface reconstruction in total stem cell deficiency. " Order ALL the reference details at left...
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 09/01/1986 - "Development of bullous pemphigoid after allogeneic bone marrow transplantation. " 01/01/2006 - "We present two patients who developed keratitis sicca and pemphigoid-like symptoms following allogeneic bone marrow transplantation (BMT). " 01/01/2006 - "Pemphigoid-like ocular lesions in patients with graft-versus-host disease following allogeneic bone marrow transplantation." 01/01/2005 - "We present two cases of patients who developed keratitis sicca (dry eyes) and pemphigoid-like symptoms after allogeneic bone marrow transplantation. " 10/01/1992 - "Bullous pemphigoid associated with acute graft-versus-host disease after allogeneic bone marrow transplantation." Order ALL the reference details at left...
5.	Transplants (Transplant) 07/01/1998 - "Bullous pemphigoid after prosthetic vascular graft placement." 01/01/2001 - "MATERIALS AND METHODS: 16 patients were treated with amnion membrane transplantation because of: pemphigoid ocularis, combustio chaemica, ulcus corneae, keratopathia bullosa, descemetocele, symblepharon, graft disease. " 07/02/1988 - "[Bullous pemphigoid following graft-versus-host reaction after bone marrow allograft]" 08/01/2002 - "Patients who are bilaterally blind from diseases such as Stevens-Johnson syndrome, and ocular pemphigoid have little hope of visual recovery from conventional corneal transplants. " 07/01/1994 - "Blistering on a squamous cell carcinoma graft site in a patient with bullous pemphigoid." Order ALL the reference details at left...

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