Dermatomyositis (Dermatopolymyositis)
1522
relevant articles (109 outcomes,
125 trials/studies)
found for this Disease
Description:
A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)
Also Known As:
Dermatopolymyositis; Polymyositis Dermatomyositis; Dermatomyositis, Adult Type; Dermatomyositis, Childhood Type; Adult Type Dermatomyositides; Adult Type Dermatomyositis; Childhood Type Dermatomyositides; Childhood Type Dermatomyositis; Dermatomyositides; Dermatomyositides, Adult Type; Dermatomyositides, Childhood Type; Dermatopolymyositides; Polymyositis-Dermatomyositides; Polymyositis-Dermatomyositis
Relationship Network
Disease Context: Research Results
Related Diseases
Experts
| 1. | Callen, Jeffrey P:
6 articles
(01/2006 - 09/2002)
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| 2. | Pachman, Lauren M:
5 articles
(02/2008 - 11/2002)
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| 3. | Lundberg, Ingrid E:
4 articles
(10/2008 - 04/2002)
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| 4. | Tamaki, Kunihiko:
4 articles
(08/2007 - 07/2002)
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| 5. | Ihn, Hironobu:
4 articles
(08/2007 - 07/2002)
|
| 6. | Kuwana, Masataka:
4 articles
(05/2007 - 05/2005)
|
| 7. | Werth, Victoria P:
4 articles
(01/2006 - 09/2002)
|
| 8. | Wedderburn, L R:
3 articles
(07/2008 - 04/2004)
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| 9. | Pilkington, C A:
3 articles
(07/2008 - 04/2004)
|
| 10. | Makino, Shigeki:
3 articles
(02/2008 - 06/2005)
|
Drugs and Biologics
Drugs and Important Biological Agents (IBA) related to Dermatomyositis:
| 1. | Intravenous Immunoglobulins (IVIG)FDA Link
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| 2. | Adrenal Cortex Hormones (Corticosteroids)IBA
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| 3. | Cyclosporine (Ciclosporin)FDA LinkGeneric
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| 4. | Immunoglobulins (Immunoglobulin)IBA
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| 5. | Methotrexate (Mexate)FDA LinkGeneric
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| 6. | Cyclophosphamide (Cytoxan)FDA LinkGeneric
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| 7. | Antineutrophil Cytoplasmic Antibodies (ANCA)IBA
01/01/2008
- " Their efficacy has been established in many clinical trials for the treatment of autoimmune rheumatic diseases including systemic lupus erythematosus, ANCA positive vasculitis and dermatomyositis, but these indications are classified as the "off label" treatment. " 01/01/2005
- " B-cell abnormalities also occur in other rheumatic diseases, eg, Sjogren's syndrome, Behcet's disease, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, and dermatomyositis. " 01/01/2005
- " Reports of rituximab treatment for ANCA-associated vasculitis and dermatomyositis are also promising. " 11/01/2001
- " PATIENTS: We examined 20 healthy subjects, 13 patients with perinuclear (myeloperoxidase, MPO) ANCA-related vasculitis and 12 dermatomyositis (DM)/polymyositis (PM) patients as disease controls in this study. " 04/01/2008
- " Recently the efficacy of rituximab against rheumatoid arthritis, systemic lupus erythematosus, polymyositis/dermatomyositis and ANCA-associated vasculitis has been recognized. "
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| 8. | rituximab (Mabthera)FDA Link
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| 9. | Prednisolone (Predate)FDA LinkGeneric
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| 10. | Azathioprine (Imuran)FDA LinkGeneric
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Therapies and Procedures
| 1. | Aftercare (After-Treatment)
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| 2. | Transplants (Transplant)
07/29/1978
- " II) concentrations in 26 patients with lupus erythematosus, 4 with dermatomyositis, 2 with autoimmune haemolytic anaemia, and in 40 immunosuppressed renal-transplant patients showed that T.C. " 06/01/2008
- " Forty-three patients (4-18 years) with renal glomerular diseases, dermatomyositis, inflammatory bowel disease, juvenile rheumatoid arthritis, post-solid organ transplant, and Duchenne muscular dystrophy were studied. " 01/01/2008
- " Besides the classical inflammatory myopathies (IM), dermatomyositis (DM), polymyositis, and inclusion body myositis, the much larger spectrum of IM includes focal and nodular myositis, granulomatous myositis, macrophagic myofasciitis, graft vs. host myositis, eosinophilic myositis, and other immune-associated conditions, some of them only recently described. " 12/01/2003
- " As a relatively well-tolerated immunosuppressive used in organ transplant recipients, MMF has recently been reported to show promise for several dermatologic conditions, including psoriasis, pemphigus vulgaris, pyoderma gangrenosum, bullous lichen planus, and even connective tissue diseases such as lupus erythematosus and dermatomyositis. " 12/01/2005
- " Since the early 1980s, the therapeutic efficacy of IVIg has been established in idiopathic thrombocytopenic purpura, Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, myasthenia gravis, dermatomyositis and Kawasaki syndrome, and the prevention of graft versus host disease in recipients of allogeneic bone marrow transplants. "
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| 3. | Drug Therapy (Chemotherapy)
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| 4. | Plasmapheresis
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| 5. | Immunotherapy
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