Formyl Peptide Receptor-1 Blockade Prevents Receptor Regulation by Mitochondrial Danger-Associated Molecular Patterns and Preserves Neutrophil Function After Trauma.
Abstract | OBJECTIVES: DESIGN: Prospective study of human and murine neutrophils and clinical cohort analysis. SETTING: University research laboratory and level 1 trauma center. PATIENTS:
Trauma patients, volunteer controls. ANIMAL SUBJECTS: C57Bl/6, formyl peptide receptor-1, and formyl peptide receptor-2 knockout mice. INTERVENTIONS: MEASUREMENTS AND MAIN RESULTS: CONCLUSIONS:
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Authors | Kiyoshi Itagaki, Elzbieta Kaczmarek, Woon Yong Kwon, Li Chen, Barbora Vlková, Quanzhi Zhang, Ingred Riça, Michael B Yaffe, Yan Campbell, Michael F Marusich, Ji Ming Wang, Wang-Hua Gong, Ji-Liang Gao, Françoise Jung, Garry Douglas, Leo E Otterbein, Carl J Hauser |
Journal | Critical care medicine
(Crit Care Med)
Vol. 48
Issue 2
Pg. e123-e132
(02 2020)
ISSN: 1530-0293 [Electronic] United States |
PMID | 31939811
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- FPR1 protein, human
- Mitochondrial Proteins
- Receptors, Formyl Peptide
- Cyclosporine
- cyclosporin H
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Topics |
- Animals
- Cyclosporine
(pharmacology)
- Humans
- Lung Injury
(physiopathology)
- Mice
- Mice, Inbred C57BL
- Mitochondrial Proteins
(immunology)
- Neutrophil Activation
(immunology)
- Neutrophils
(immunology)
- Receptors, Formyl Peptide
(antagonists & inhibitors)
- Respiratory Tract Infections
(physiopathology)
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