Abstract | INTRODUCTION:
Intrahepatic cholangiocarcinoma (ICC) accounts for 10% to 15% of all primary hepatic carcinomas. However, there are no effective drug treatment strategies against ICC, and surgery is currently the only curative treatment. Here, we present a case of ICC successfully treated with anlotinib, a novel oral agent. PATIENT CONCERNS: The patient was a 66-year-old Han Chinese woman, and she was a retired worker. The patient had no history of hepatitis B infection or hypertension. Physical examination showed no abnormalities, and the patient showed no conscious discomfort. However, ultrasound revealed liver occupation. DIAGNOSIS: Liver ultrasound and enhanced computed tomography (CT) indicated liver cancer with intrahepatic metastasis. Serum carbohydrate antigen 199 and alpha fetoprotein levels were high at 4270 and 1561 ng/mL, respectively. Pathologic findings of CT-guided liver biopsy revealed an adenocarcinoma. Owing to further immunohistochemical staining and clinical results, a diagnosis of ICC was made. INTERVENTIONS: OUTCOMES: This patient showed a partial response after 2 cycles of treatment with anlotinib (12 mg daily, days 1-14 of a 21-day cycle). Drug-related side effects, such as hypertension and hand foot skin reaction, were observed. After 4 cycles of anlotinib, the efficacy appeared to be stable, and the patient showed a progression-free survival period of almost 4 months. However, the patient's condition worsened and she died of liver failure 6 months after treatment (overall survival, almost 6 months). CONCLUSION: Some cases of ICC may be responsive to the antiangiogenic drug, anlotinib, when combined with microwave ablation. Randomized clinical studies are required to further confirm the efficacy and safety of anlotinib in the clinical treatment of ICC.
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Authors | Aixia Zhang, Bin Liu, Dandan Xu, Yahong Sun |
Journal | Medicine
(Medicine (Baltimore))
Vol. 98
Issue 52
Pg. e18435
(Dec 2019)
ISSN: 1536-5964 [Electronic] United States |
PMID | 31876723
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Indoles
- Quinolines
- anlotinib
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Topics |
- Aged
- Antineoplastic Agents
(therapeutic use)
- Bile Duct Neoplasms
(diagnosis, diagnostic imaging, therapy)
- Cholangiocarcinoma
(diagnosis, diagnostic imaging, therapy)
- Combined Modality Therapy
- Female
- Humans
- Indoles
(therapeutic use)
- Microwaves
(therapeutic use)
- Quinolines
(therapeutic use)
- Tomography, X-Ray Computed
- Ultrasonography
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