alpha-Fetoproteins (AFP)

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7500 relevant articles (240 outcomes, 715 trials/studies) found for this Bio-Agent

Description: The first alpha-globulins to appear in mammalian sera during development of the embryo and the dominant serum proteins in early embryonic life. They reappear in the adult serum during certain pathologic states, primarily hepatocellular carcinoma. They may also be elevated in the amniotic fluid and maternal serum during pregnancy in ANENCEPHALY.

Also Known As:

AFP; alpha-Fetoprotein; Fetoprotein; Fetuin; alpha Fetoprotein; alpha Fetoproteins; Fetuins

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ketteler, Markus: 7 articles (04/2008 - 03/2005)
2.	Satomura, Shinji: 7 articles (10/2007 - 11/2002)
3.	Butterfield, Lisa H: 5 articles (03/2008 - 12/2003)
4.	Tamaoki, T: 5 articles (09/2003 - 01/2001)
5.	Satomura, S: 5 articles (12/2001 - 02/2001)
6.	Stenvinkel, Peter: 4 articles (01/2008 - 01/2006)
7.	Lindholm, Bengt: 4 articles (01/2008 - 01/2006)
8.	Li, Gang: 4 articles (05/2007 - 06/2002)
9.	Mizejewski, Gerald J: 4 articles (01/2007 - 09/2002)
10.	Sata, Michio: 4 articles (09/2006 - 06/2002)

Related Diseases

1.	Neoplasms (Cancer) 06/21/2000 - "The most striking finding was that women with high levels of serum alpha-fetoprotein, compared with women with low levels of serum alpha-fetoprotein, showed a particularly reduced incidence of large tumors (>2 cm; RR = 0.24 [95% CI = 0.11-0.50]). " 12/01/1999 - "For most tumors, T/Th for AFP and DIII was significantly greater than T/Th for Tc-99m sestamibi and Tl-201. " 12/01/1987 - "This striking molecular variation of the alpha-fetoprotein produced by these different tumors is helpful in the clinical distinction of these tumors." 01/01/1997 - "Interestingly, these three patients with a pathological increase in beta HCG and AFP as determined in the supernatant of the short-term cell cultures had tumor progression within a mean follow-up of 3 +/- 1 months (P < 0.01), whereas 9 of 12 patients who had no pathological increase in beta HCG and AFP as determined in the supernatant of the short-term cell culture were in complete remission (CR) after a mean follow-up of 40 +/- 11.6 months." 07/01/1992 - "After HAI+HAE, the frequency of greater than or equal to 50% reduction in tumor size was 67.5% (27/40); that of reduction in marked and partial disappearance of tumor blood vessels was 90% (36/40); and that of marked decrease and normalized AFP was 90.3% (28/31). " Order ALL the reference details at left...
2.	Hepatocellular Carcinoma (Hepatoma) 01/01/1983 - "Serial measurement of AFP appears to be the most helpful for detection of hepatocellular carcinoma at the early stage, particularly in cirrhotic patients. " 07/01/2003 - "CONCLUSIONS: The paucity of high-quality data calls for more rigorous study of AFP and other diagnostic tests for detecting hepatocellular carcinoma in HCV-infected patients with an accepted gold standard applied to the entire cohort. " 02/01/2006 - "A significantly greater proportion of respondents screened for hepatocellular carcinoma using either alpha-fetoprotein or ultrasound every 6 months (P < 0.05). " 03/01/1993 - "It is promising that the saliva AFP surveillance may be helpful in detection of AFP positive hepatocellular carcinoma, because of its noninvasiveness, acceptableness by almost every person, simplicity in technique, and the strong correlation between saliva and serum AFP." 11/15/2001 - "Alpha-fetoprotein testing and ultrasonography can be effective in screening for hepatocellular carcinoma. " Order ALL the reference details at left...
3.	Neoplasm Metastasis (Metastasis) 01/01/1987 - "For an early detection of metastases the best results (efficiency 0.92) were achieved with the combination of beta-HCG with AFP and X-ray examination of the chest." 05/01/2001 - "After these treatments, the multiple liver metastases were reduced remarkably, with a marked decrease of serum AFP levels. " 01/01/1978 - "Regular screening with beta-HCG and AFP, has improved the early diagnosis of recurrences and metastases in nonseminomatous testicular tumours." 01/01/2002 - "The aim of this study is to evaluate usefulness of plasma CT, CEA and AFP assay in the early detection of relapse or metastasis of MTC. " 10/01/2001 - "We analyzed a concentration of AFP in preliminary study and in monitoring depending on clinical advances of tumour, mass of primary tumour and metastases to lymph nodes. " Order ALL the reference details at left...
4.	Down Syndrome (Down's Syndrome) 08/01/2002 - "CONCLUSION: Integration of NT and second trimester serum AFP and hCG assay yielded the best screening efficacy for Down syndrome." 03/01/1999 - "CONCLUSIONS: A policy of first trimester scanning followed by serum alpha-fetoprotein screening and additional scanning as clinically indicated is effective in detecting major structural abnormalities, but scanning at 18-22 weeks and serum biochemical screening for trisomy 21 improved the detection rates. " 08/01/1994 - "CONCLUSION: These results support the mathematical model that hCG is the major contributor to the increased sensitivity of multi-analyte screening and demonstrate that screening programs can attain substantial improvement in detection of second-trimester Down syndrome by adding hCG to AFP and age." 12/01/1995 - "AFP, hCG, uE3] has been found effective in identifying the majority of pregnancies with Down syndrome in the second trimester. " 03/01/2000 - "CONCLUSIONS: A new algorithm combining humerus length and nuchal thickness measurement with serum AFP, hCG and maternal age substantially improved Down syndrome screening efficiency compared with the traditional triple screen. " Order ALL the reference details at left...
5.	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor) 03/01/2000 - "MATERIALS AND METHODS: Histories of 6 cases of germ cell tumors that remained in remission despite abnormal serum AFP and/or HCG were reviewed. " 04/01/2005 - "PURPOSE: The aim of the present study was to evaluate survival and factors influencing long-term outcome of patients with AFP/beta-HCG secreting (non-seminomatous) central nervous system germ cell tumors (secCNSGCT), who were prospectively collected in the cooperative MAKEI (German: maligne Keimzelltumoren) 89 protocol. " 09/01/2003 - "A study on the microheterogeneity of alpha-fetoproteins produced by yolk sac and germ cell tumors." 05/01/2001 - "Coexistence of other components of ovarian germ cell tumors in histologic specimens, preoperative serum alpha-fetoprotein level, fertility-sparing surgery, dissection of intrapelvic nodes, and p53 status had no significant correlation with the prognosis in this study. " 07/15/1993 - "The current study indicates that the most characteristic feature of glycosylation of AFP in germ cell tumors is fucosylation rather than glucosaminylation." Order ALL the reference details at left...

Related Drugs and Biologics

1.	alpha-Fetoproteins (AFP)
2.	Chorionic Gonadotropin (Human Chorionic Gonadotropin)
3.	acarboxyprothrombin (DCP)
4.	Biological Tumor Markers (Tumor Markers)
5.	Biological Markers (Surrogate Marker)
6.	Estriol (Epiestriol)
7.	lentil lectin
8.	Cisplatin (Platino)
9.	Carcinoembryonic Antigen
10.	Antigens

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Combination Drug Therapy (Combination Chemotherapy)
3.	Aftercare (After-Treatment)
4.	Heterologous Transplantation (Xenotransplantation)
5.	Liver Transplantation

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