Fucoxanthin-Rich Brown Algae Extract Improves Male Reproductive Function on Streptozotocin-Nicotinamide-Induced Diabetic Rat Model.

Abstract

Hypogonadism and oxidative stress are occurring commonly in men with diabetes and associated male infertility. This study aimed to investigate the capability of anti-oxidative and anti-inflammatory properties of fucoxanthin as well as to evaluate its protective effects on male reproduction in diabetic rats. The RAW 264.7 macrophage cells were used to evaluate the anti-oxidative and anti-inflammatory activity. Thirty male Sprague-Dawley rats were induced by streptozotocin-nicotinamide for a diabetes model and fed either with three different doses of fucoxanthin (13, 26, and 65 mg/kg) or rosiglitazone (0.571 mg/kg) for four weeks. The fucoxanthin significantly inhibited nitric oxide production and reduced reactive oxygen species level in lipopolysaccharide-induced RAW 264.7 cells. In the animal study, fucoxanthin administration improved insulin resistance, restored sperm motility, decreased abnormal sperm number, and inhibited lipid peroxidation. Moreover, it restored GPR54 and SOCS-3 mRNA expression in the hypothalamus and recovered luteinizing hormone level, as well as the testosterone level. In conclusion, fucoxanthin not only possessed antioxidant and anti-inflammatory properties but also decreased the diabetes signs and symptoms as well as improved spermatogenesis and male reproductive function.

• Authors: Zwe-Ling Kong, Sabri Sudirman, Yu-Chun Hsu, Chieh-Yu Su, Hsiang-Ping Kuo
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 20 Issue 18 (Sep 11 2019) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 31514311 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Blood Glucose
• Inflammation Mediators
• Insulin
• Kiss1r protein, rat
• Kisspeptins
• RNA, Messenger
• Reactive Oxygen Species
• Receptors, Kisspeptin-1
• Suppressor of Cytokine Signaling 3 Protein
• Xanthophylls
• fucoxanthin
• Niacinamide
• Nitric Oxide
• Malondialdehyde
• Streptozocin

Topics

• Animals
• Antioxidants (metabolism)
• Blood Glucose (metabolism)
• Cell Survival (drug effects)
• Diabetes Mellitus, Experimental (chemically induced, drug therapy, physiopathology)
• Disease Models, Animal
• Inflammation Mediators (metabolism)
• Insulin (blood)
• Insulin Resistance
• Kisspeptins (genetics, metabolism)
• Male
• Malondialdehyde (metabolism)
• Mice
• Niacinamide
• Nitric Oxide (metabolism)
• Oxidative Stress (drug effects)
• Phaeophyta (chemistry)
• RAW 264.7 Cells
• RNA, Messenger (genetics, metabolism)
• Rats, Sprague-Dawley
• Reactive Oxygen Species (metabolism)
• Receptors, Kisspeptin-1 (genetics, metabolism)
• Reproduction (drug effects)
• Spermatozoa (drug effects, metabolism)
• Streptozocin
• Suppressor of Cytokine Signaling 3 Protein (genetics, metabolism)
• Testis (drug effects, pathology)
• Xanthophylls (pharmacology, therapeutic use)