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Luteinizing Hormone (Lutropin)

A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.
Also Known As:
Lutropin; LH (Luteinizing Hormone); Interstitial Cell-Stimulating Hormone; Luteoziman; Luteozyman; Hormone, Interstitial Cell-Stimulating; Hormone, Luteinizing; Interstitial Cell Stimulating Hormone; ICSH (Interstitial Cell Stimulating Hormone); Luteinizing hormone
Networked: 3161 relevant articles (60 outcomes, 228 trials/studies)

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Drug Context: Research Results

Experts

1. Huhtaniemi, Ilpo: 13 articles (01/2019 - 05/2003)
2. Smith, Mark A: 11 articles (07/2014 - 11/2002)
3. Tsukamura, Hiroko: 10 articles (06/2022 - 01/2009)
4. Uenoyama, Yoshihisa: 9 articles (06/2022 - 01/2009)
5. Atwood, Craig S: 9 articles (04/2008 - 11/2002)
6. Perry, George: 9 articles (12/2007 - 11/2002)
7. Inoue, Naoko: 8 articles (06/2022 - 01/2009)
8. Genazzani, Alessandro D: 8 articles (01/2018 - 01/2004)
9. Rao, C V: 8 articles (01/2017 - 01/2000)
10. Veldhuis, Johannes D: 8 articles (01/2017 - 04/2002)

Related Diseases

1. Insulin Resistance
2. Body Weight (Weight, Body)
11/01/2020 - "Total body weight and ovarian weight, as well as the levels of luteinizing hormone (LH) and the LH to follicle‑stimulating hormone (FSH) ratio (LH/FSH) significantly increased in rats with PCOS, compared with controls. "
05/01/2015 - "Although the consumption of the HFD did not affect the serum luteinizing hormone levels or body weight of the IUGR or control rats, it did promote vaginal opening in both groups (evaluated in 14 rats per group). "
09/01/2013 - "After 48 days of treatment, sperm concentrations were (87.85 +/- 28.44), (7.11 +/- 2.15), (35.98 +/- 14.04), (32.65 +/- 11.80) and (33.51 +/- 13.26) x 10(6)/ml in the blank control, infertile model, high-dose YJF, mid-dose YJF, and low-dose YJF groups, respectively; sperm motilities were (52.79 +/- 16.43), (31.14 +/- 3.07), (45.88 +/- 16.97), (51.56 +/- 13.35) and (49.53 +/- 10.16)%; the T levels were (194.07 +/- 40.29), (61.27 +/- 13.70), (121.87 +/- 24.35), (127.44 +/- 19.38) and (127.81 +/- 20.28) nmol/L; the luteinizing hormone (LH) levels were (7.017 +/- 0.269), (6.117 +/- 0.894), (7.060 +/- 0.871), (7.156 +/- 0.937) and (6.967 +/- 0.778) IU/L; the testis volumes were (3.775 +/- 0.183), (2.865 +/- 0.258), (3.236 +/- 0.058), (3.457 +/- 0.066) and (3.398 +/- 0.091) g; the epididymis volumes were (1.119 +/- 0.116), (0.833 +/- 0.226), (1.124 +/- 0.104), (1.132 +/- 0.107) and (1.114 +/- 0.106) g; the prostate volumes were (176.75 +/- 427.09), (131.67 +/- 39.45), (178.70 +/- 37.97), (180.11 +/- 37.39) and (179.00 +/- 35.42) mg; and the body weights were (188.50 +/- 7.12), (189.92 +/- 6.67), (187.42 +/- 5.47), (189.17 +/- 6.19) and (188.75 +/- 6.12) g. "
08/01/2005 - "In male rodents and primates, intracerebroventricular (icv) infusions of GALP stimulate luteinizing hormone (LH) release, induce Fos expression in brain areas implicated in feeding and reproduction, and affect food intake and body weight in rodents. "
11/01/1997 - "The independent effects of age and body weight (BW) on photostimulatory response in turkey breeder hens were studied by measuring changes in plasma luteinizing hormone (LH; ng/mL) before and 3 d after photostimulation. "
3. Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal)
4. Neoplasms (Cancer)
5. Infertility (Sterility)

Related Drugs and Biologics

1. Follicle Stimulating Hormone (Follitropin)
2. Testosterone (Sustanon)
3. Estradiol (Delestrogen)
4. Gonadotropin-Releasing Hormone (GnRH)
5. Prolactin
6. Insulin (Novolin)
7. Androgens
8. Progesterone
9. Metformin (Glucophage)
10. Androstenedione (4 Androstene 3,17 dione)

Related Therapies and Procedures

1. Therapeutics
2. Castration
3. Aftercare (After-Treatment)
4. Hormone Replacement Therapy (Therapy, Hormone Replacement)
5. Orchiectomy (Orchidectomy)