Abstract | OBJECTIVES:
Vitamin D deficiency may be associated with comorbidities and poor prognosis. However, this association in patients in the intensive care unit (ICU) has not been fully elucidated. The aim of this study was to investigate whether the serum concentrations of 25-hydroxyvitamin D (25[ OH]D) within the first 48 h after ICU admission are associated with prognostic indicators (Acute Physiology and Chronic Health Evaluation [APACHE] II, Sequential Organ Failure Assessment [SOFA] score, Charlson comorbidity index [CCI]), clinical complications, serum C-reactive protein (CRP) concentrations, mechanical ventilation duration, and mortality. METHODS: Seventy-one patients were admitted to the ICU, and their concentrations of 25( OH)D in the first 48 h were analyzed. To evaluate the prognostic factors in the ICU, APACHE II scores, SOFA scores, CCI questionnaires, mechanical ventilation time, CRP, and mortality were used. RESULTS: The mean concentration of 25( OH)D was 17.7 ± 8.27 ng/mL (range 3.5-37.5 ng/mL), with 91.6% presenting with deficiency at admission. Although no associations were found between serum 25( OH)D concentrations with mechanical ventilation time, CRP, mortality, and APACHE II and SOFA severity scores, we found associations with the CCI when adjusted by age (model 1: odds ratio [OR], 1.64; 95% confidence interval [CI], 1.14-2.34) and by age, sex and body mass index (model 2: OR, 1.59; 95% CI, 1.10-2.34). In addition, among the comorbidities present, 25( OH)D concentrations were inversely associated with cancer (crude model OR, 3.42; 95% CI, 1.21-9.64) and liver disease (crude model OR, 9.64; 95% CI, 2.28-40.60). CONCLUSION:
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Authors | Tatyanne Ln Gomes, Renata C Fernandes, Liana L Vieira, Raquel M Schincaglia, João F Mota, Marciano S Nóbrega, Claude Pichard, Gustavo D Pimentel |
Journal | Nutrition (Burbank, Los Angeles County, Calif.)
(Nutrition)
Vol. 60
Pg. 235-240
(04 2019)
ISSN: 1873-1244 [Electronic] United States |
PMID | 30682545
(Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2019 Elsevier Ltd. All rights reserved. |
Chemical References |
- Vitamin D
- C-Reactive Protein
- 25-hydroxyvitamin D
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Topics |
- APACHE
- Acute Disease
- Adult
- Aged
- C-Reactive Protein
(analysis)
- Comorbidity
- Critical Illness
(mortality)
- Cross-Sectional Studies
- Female
- Hospital Mortality
- Humans
- Infections
(blood, complications, mortality)
- Intensive Care Units
- Liver Failure
(blood, complications, mortality)
- Male
- Middle Aged
- Neoplasms
(blood, complications, mortality)
- Organ Dysfunction Scores
- Patient Admission
(statistics & numerical data)
- Prognosis
- Respiration, Artificial
- Respiratory Insufficiency
(blood, complications, mortality)
- Severity of Illness Index
- Time Factors
- Vitamin D
(analogs & derivatives, blood)
- Vitamin D Deficiency
(blood, complications, mortality)
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