[A Case of Neuroendocrine Carcinoma of the Ascending Colon That Responded Completely to Chemotherapy].

Abstract

We report a case of effective treatment comprising mFOLFOX6 plus bevacizumab for neuroendocrine carcinoma of the ascending colon. A 60-year-old woman was admitted for diarrhea and abdominal pain. Colonoscopy showed a Type 2 tumor in the ascending colon. She was diagnosed with neuroendocrine cell carcinoma based on biopsy and immunostaining. CT and MRI showed liver metastasis and lymph node #12a metastasis. Right hemi-colectomy, lymphadenectomy, and partial hepatectomy were performed(T4a, N2, M1b, Stage IV). Neuroendocrine cell carcinoma(small-cell type)was finally diagnosed based on a histological examination because the nuclear fission image was 30(/10HPF)and the Ki-67 index was 42%. Three months after the surgery, multiple lymph node metastases were found using CT and MRI. mFOLFOX6 plus bevacizumab was initiated. After 4 courses of the chemotherapy, the metastases responded completely. A total of 10 courses of chemotherapy were administered. About 2 years and 6 months after the surgery, no recurrence is allowed.

• Authors: Masaya Satake, Kazuhiko Yoshimatsu, Yoshitomo Ito, Rie Imaizumi, Megumi Sano, Asaka Kodera, Yutaka Miyano, Taro Koike, Yasufumi Yamada, Sachiyo Okayama, Hajime Yokomizo, Takebumi Usui, Kentaro Yamaguchi, Shunichi Shiozawa, Takeshi Shimakawa, Takao Katsube, Yoshihiko Naritaka
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 45 Issue 10 Pg. 1513-1515 (Oct 2018) ISSN: 0385-0684 [Print] Japan
• PMID: 30382062 (Publication Type: Case Reports, Journal Article)

Chemical References

• Organoplatinum Compounds
• Bevacizumab
• Leucovorin
• Fluorouracil

Topics

• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Bevacizumab (administration & dosage)
• Carcinoma, Neuroendocrine (drug therapy, surgery)
• Colectomy
• Colon, Ascending (pathology, surgery)
• Colonic Neoplasms (drug therapy, pathology, surgery)
• Female
• Fluorouracil (administration & dosage)
• Hepatectomy
• Humans
• Leucovorin (administration & dosage)
• Liver Neoplasms (drug therapy, secondary, surgery)
• Middle Aged
• Organoplatinum Compounds (administration & dosage)