Abstract | BACKGROUND: METHODS: RESULTS: Baseline CRP levels were positively associated with the odds of asthma but not diabetes or sleep apnea; baseline CC levels were positively associated with asthma, diabetes, and sleep apnea; baseline leptin levels were positively associated with asthma and negatively associated with diabetes and sleep apnea; baseline ghrelin levels were negatively associated with diabetes and sleep apnea. Increased weight loss was associated with increased baseline levels of leptin and CRP and decreased baseline levels of CC. Remission of diabetes and asthma was not associated with baseline levels of any biomarker. A higher likelihood of asthma remission was associated with a greater decrease in leptin levels, and a higher likelihood of diabetes remission was predicted by a lesser decrease in CC. Bariatric surgery was associated with decreased post-operative CC, CRP, and leptin levels, and increased post-operative ghrelin levels. CONCLUSION:
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Authors | Robert W O'Rourke, Geoffrey S Johnson, Jonathan Q Purnell, Anita P Courcoulas, Gregory F Dakin, Luis Garcia, Marcelo Hinojosa, James E Mitchell, Alfons Pomp, Walter J Pories, Konstantinos Spaniolas, David R Flum, Abdus S Wahed, Bruce M Wolfe |
Journal | International journal of obesity (2005)
(Int J Obes (Lond))
Vol. 43
Issue 2
Pg. 285-296
(02 2019)
ISSN: 1476-5497 [Electronic] England |
PMID | 29777230
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Biomarkers
- Ghrelin
- Leptin
- C-Reactive Protein
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Topics |
- Adiposity
(physiology)
- Adult
- Bariatric Surgery
(statistics & numerical data)
- Biomarkers
(blood)
- C-Reactive Protein
(analysis)
- Female
- Ghrelin
(blood)
- Humans
- Inflammation
(blood, epidemiology)
- Leptin
(blood)
- Longitudinal Studies
- Male
- Metabolic Diseases
(blood, epidemiology)
- Middle Aged
- Obesity
(blood, epidemiology, surgery)
- Treatment Outcome
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