Abstract | PURPOSE: METHODS: RESULTS:
Weight loss was accompanied by significant reduction of PTH levels (77.9 ± 19.1 vs. 60.5 ± 13.4 pg/ml; p = 0.005), without concomitant modification of 25OHD status. Both baseline PTH and its postoperative percent change resulted associated, with baseline fat mass (β = 0.615, p = 0.003) and its concurrent postoperative reduction (r = 0.419; p = 0.006), but neither with glucose homeostasis parameters nor their respective variations after weight loss. Interestingly, leptin reduction after weight loss was independently related to PTH change (β = 0.396, p = 0.015) and IGF-1 levels (β = 0.176, p = 0.059). CONCLUSIONS: Circulating PTH decreases with fat mass reduction independent of 25OHD status, but it is not associated with improvement of insulin resistance and related metabolic parameters. Leptin and PTH may mediate the cross-talk between adipose tissue and parathyroid glands, which possibly contributes to bone adaptation to excess body weight.
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Authors | Valeria Guglielmi, Alfonso Bellia, Paolo Gentileschi, Mauro Lombardo, Monica D'Adamo, Davide Lauro, Paolo Sbraccia |
Journal | Endocrine
(Endocrine)
Vol. 59
Issue 2
Pg. 288-295
(02 2018)
ISSN: 1559-0100 [Electronic] United States |
PMID | 29168114
(Publication Type: Journal Article)
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Chemical References |
- Blood Glucose
- Insulin
- Leptin
- Parathyroid Hormone
- Vitamin D
- 25-hydroxyvitamin D
- Calcium
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Topics |
- Adult
- Bariatric Surgery
- Blood Glucose
- Body Mass Index
- Calcium
(blood)
- Female
- Humans
- Insulin
(blood)
- Insulin Resistance
- Leptin
(blood)
- Male
- Middle Aged
- Obesity, Morbid
(blood, surgery)
- Parathyroid Hormone
(blood)
- Vitamin D
(analogs & derivatives, blood)
- Weight Loss
(physiology)
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