Abstract | Introduction: Methods: Spontaneous nicotine withdrawal in nicotine-dependent ICR male mice was established 18-24 h after termination (minipump removal) of 14 days infusion of nicotine. After that (day 15), spontaneous signs of nicotine withdrawal were examined in the following order: anxiety-like behaviors, somatic signs, and then hyperalgesia using previously published behavioral protocols. Fifteen minutes before withdrawal signs testing, mice received a subcutaneous acute injection of vehicle or dFBr at the doses of 0.02, 0.1, and 1 mg/kg to determine the effect of dFBr on nicotine withdrawal symptoms. Results: dFBr produced dose-dependent reversal of nicotine withdrawal signs in mouse model of spontaneous nicotine withdrawal. Implications: Positive allosteric modulators of nAChR such as dFBr reduce nicotine withdrawal symptoms supporting the potential clinical use of this novel class of nAChR-based therapeutics as smoking cessation aid.
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Authors | Ayman K Hamouda, Asti Jackson, Deniz Bagdas, M Imad Damaj |
Journal | Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
(Nicotine Tob Res)
Vol. 20
Issue 7
Pg. 903-907
(06 07 2018)
ISSN: 1469-994X [Electronic] England |
PMID | 29059422
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hydrocarbons, Brominated
- Indole Alkaloids
- Nicotinic Agonists
- Receptors, Nicotinic
- desformylflustrabromine
- nicotinic receptor alpha4beta2
- Nicotine
- Varenicline
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Topics |
- Allosteric Regulation
(drug effects, physiology)
- Animals
- Hydrocarbons, Brominated
(pharmacology, therapeutic use)
- Indole Alkaloids
(pharmacology, therapeutic use)
- Infusion Pumps, Implantable
- Male
- Mice
- Mice, Inbred ICR
- Nicotine
(administration & dosage, adverse effects)
- Nicotinic Agonists
(pharmacology, therapeutic use)
- Receptors, Nicotinic
(physiology)
- Smoking Cessation
(methods)
- Substance Withdrawal Syndrome
(drug therapy, physiopathology)
- Varenicline
(pharmacology, therapeutic use)
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