Nicotine

Subscribe to Selected New Research on Nicotine

4456 relevant articles (248 outcomes, 656 trials/studies) found for this Drug

Description: Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

Also Known As:

Nicotine Bitartrate; Nicotine Tartrate; Bitartrate, Nicotine; Tartrate, Nicotine; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 25

Alkaloids: 691

Solanaceous Alkaloids: 3

Nicotine: 4456

nicotine polacrilex: 21

nornicotine: 12

metanicotine: 9

N-methyl-nicotine: 4

N-octanoylnornicotine: 2

SIB1663: 1

1-benzyl-4-phenylnicotinamidinium

2,3,3a,4,5,9b-hexahydro-1-methyl-1H-pyrrolo(3,2-h)isoquinoline

2,4,5,6-tetradeuterocotinine

3',3'-dideuteronicotine

3,4-dihydrometanicotine

4'-methylnicotine

4-(dimethylphenylsilyl)nicotine

4-hydroxynicotine

5'-acetoxy-N'-nitrosonornicotine

5'-cyanonicotine

5-fluoronicotine

5-iodonicotine

5-isothiocyanonicotine

5-methoxynicotine

6-(2-phenylethyl)nicotine

6-hydroxynicotine

6-n-propylnicotine

7,8-difluoro-1,2,3,4,5,6- hexahydro-1,5-methano-3-benzazocine

homoazanicotine

K(s-nic)5(Ga2(N,N'-bis-(2,3-dihydroxybenzoyl)-1,4-phenylenediamine)3)

N'-carbomethoxynornicotine

N'-formylnornicotine

N'-methylnicotinium

N'-propylnornicotine

N-(n-dec-9-enyl)nicotinium

N-(n-oct-3-enyl)nicotinium

N-4-azido-2-nitrophenylnornicotine

N-methyl-N'-oxonicotinium

N-methylnicotinium

N-methylnicoton

N-methylnornicotinium

nicotine monomethiodide

nicotine N-glucuronide

nicotinium molybdophosphate resin

pseudooxynicotine

1-Ring Heterocyclic Compounds

Pyridines: 28

Nicotine: 4456

nicotine polacrilex: 21

nornicotine: 12

metanicotine: 9

N-methyl-nicotine: 4

N-octanoylnornicotine: 2

SIB1663: 1

1-benzyl-4-phenylnicotinamidinium

2,3,3a,4,5,9b-hexahydro-1-methyl-1H-pyrrolo(3,2-h)isoquinoline

2,4,5,6-tetradeuterocotinine

3',3'-dideuteronicotine

3,4-dihydrometanicotine

4'-methylnicotine

4-(dimethylphenylsilyl)nicotine

4-hydroxynicotine

5'-acetoxy-N'-nitrosonornicotine

5'-cyanonicotine

5-fluoronicotine

5-iodonicotine

5-isothiocyanonicotine

5-methoxynicotine

6-(2-phenylethyl)nicotine

6-hydroxynicotine

6-n-propylnicotine

7,8-difluoro-1,2,3,4,5,6- hexahydro-1,5-methano-3-benzazocine

homoazanicotine

K(s-nic)5(Ga2(N,N'-bis-(2,3-dihydroxybenzoyl)-1,4-phenylenediamine)3)

N'-carbomethoxynornicotine

N'-formylnornicotine

N'-methylnicotinium

N'-propylnornicotine

N-(n-dec-9-enyl)nicotinium

N-(n-oct-3-enyl)nicotinium

N-4-azido-2-nitrophenylnornicotine

N-methyl-N'-oxonicotinium

N-methylnicotinium

N-methylnicoton

N-methylnornicotinium

nicotine monomethiodide

nicotine N-glucuronide

nicotinium molybdophosphate resin

pseudooxynicotine

Experts

1.	Aleisa, A M: 6 articles (10/2008 - 01/2006)
2.	Alkadhi, K A: 6 articles (10/2008 - 01/2006)
3.	Alzoubi, K H: 6 articles (10/2008 - 01/2006)
4.	Quik, Maryka: 5 articles (10/2008 - 10/2002)
5.	Sudheer, Adluri Ram: 5 articles (01/2008 - 01/2007)
6.	Rhodes, J: 5 articles (01/2008 - 11/2000)
7.	Cho, Chi-Hin: 5 articles (06/2007 - 12/2004)
8.	Shin, Vivian Y: 5 articles (11/2005 - 05/2002)
9.	Benowitz, Neal L: 4 articles (09/2008 - 11/2005)
10.	Muthukumaran, Shanmugavelu: 4 articles (01/2008 - 01/2007)

Related Diseases

1.	Tobacco Use Disorder (Nicotine Dependence) 12/01/2005 - "Nicotine replacement therapies (NRT) are an effective treatment for tobacco dependence, yet most smokers do not quit or remain abstinent. " 01/01/2005 - "The effect of active NRT treatment did not differ significantly by smoking rate or nicotine dependence, with the exception that the nicotine patch was significantly more effective than placebo in highly dependent smokers. " 03/01/1996 - "CONCLUSION: Nicotine transdermal patches were most effective for smokers with moderate nicotine dependence and for younger smokers. " 01/01/2006 - "The invention of nicotine gum was a major treatment advance and also greatly helped our understanding of the nature of tobacco dependence. " 02/01/2001 - "CONCLUSION: Residential treatment for tobacco dependence is superior to outpatient treatment in some smokers who are moderately to severely nicotine dependent." Order ALL the reference details at left...
2.	Substance Withdrawal Syndrome (Withdrawal Symptoms) 11/01/1995 - "Withdrawal symptom relief can be improved with more complete nicotine replacement. " 08/01/2007 - "Women with Childhood Onset weight problems reported first trying cigarettes at a significantly younger age than those with Later Onset (13 vs. 15 years of age, respectively), and they reported more nicotine withdrawal symptoms during smoking abstinence, with a significantly greater likelihood of endorsing anger/irritability and trouble concentrating. " 12/11/1991 - "All transdermal nicotine doses significantly decreased the severity of nicotine withdrawal symptoms and significantly reduced cigarette use by patients who did not stop smoking. " 01/01/1999 - "While there are a limited number of reported studies with mixed findings using higher than the standard nicotine patch dose, use of higher doses of nicotine patch therapy (i.e., more than one patch at a time) may be appropriate for smokers who previously failed single dose patch therapy or in those whose nicotine withdrawal symptoms were not adequately relieved with standard therapy. " 09/01/1992 - "The partial replacement of plasma nicotine, which would have otherwise been obtained from cigarettes, reduces the severity of nicotine withdrawal symptoms, and so allows the smoker to abstain from smoking more easily. " Order ALL the reference details at left...
3.	Schizophrenia (Dementia Praecox) 02/01/2008 - "In summary, nicotine improved attentional performance in both groups and was associated with greater improvements in inhibition of impulsive responses in subjects with schizophrenia. " 02/01/2008 - "In addition, nicotine reduced commission errors on the CPT-IP and improved the performance on a Card Stroop task to a greater extent in those with schizophrenia vs controls. " 06/01/2009 - "Although evidence suggests that nicotine replacement therapy (NRT), relative to placebo, enhances spatial working memory (SWM) in smoking-abstinent smokers with schizophrenia, the extent to which NRT may be helpful in attenuating abstinence-related SWM in other groups with deficits in SWM is unknown. " 12/01/2005 - "This study was designed to determine the feasibility and efficacy of long-term nicotine replacement therapy (NRT) in helping persons with schizophrenia remain tobacco-free. " 03/01/2005 - "Furthermore, several studies using evoked potentials (P50 paradigm) and prepulse inhibition of the acoustic startle reflex suggest that deficient preattentive information processing, a core feature of schizophrenia illness, is improved following treatment with nicotine. " Order ALL the reference details at left...
4.	Ulcerative Colitis 04/01/1997 - "The most recent clinical trials on the use of nicotine in the management of ulcerative colitis have suggested that nicotine, in combination with conventional pharmacologic therapy, may result in clinical improvement in some patients. " 04/13/1995 - "Transdermal nicotine alone was no better than placebo in the maintenance of remission of ulcerative colitis, and premature withdrawal due to side effects was more common in the nicotine group." 02/01/1998 - "I've heard that the nicotine skin patch is a new treatment for ulcerative colitis. " 05/01/1999 - "Controlled trials have demonstrated efficacy of transdermal nicotine for active ulcerative colitis. " 11/01/1999 - "Long-term effects of a single course of nicotine treatment in acute ulcerative colitis: remission maintenance in a 12-month follow-up study." Order ALL the reference details at left...
5.	Alzheimer Disease (Alzheimer's Disease) 01/01/2001 - "REVIEWER'S CONCLUSIONS: This review is not able to provide any evidence that nicotine is a useful treatment for Alzheimer's disease." 01/01/2000 - "REVIEWER'S CONCLUSIONS: This review is not able to provide reliable evidence that nicotine is a useful treatment for Alzheimer's disease." 02/01/2004 - "OBJECTIVES: Chronic transdermal nicotine has been found to improve attentional performance in patients with Alzheimer's disease (AD), but little is known about chronic nicotine effects in age-associated memory impairment (AAMI), a milder form of cognitive dysfunction. " 12/01/2001 - "RATIONALE: Nicotine has been found to improve cognitive functions in patients with Alzheimer's disease, but little is known about its effects in the healthy non-smoking elderly. " 01/01/1993 - "Nicotine has also been shown to improve performance in some cognitive tests in patients with Alzheimer's disease. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Bupropion (Wellbutrin)
2.	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)
3.	Cocaine (Cocaine HCl)
4.	Cotinine
5.	Acetylcholine (Acetylcholine Chloride)
6.	Smoke
7.	Ethanol (Ethyl Alcohol)
8.	Chewing Gum (Chewing Gums)
9.	Nicotine
10.	N-Methylaspartate (NMDA)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Self Administration (Administration, Self)
3.	Enema (Enemas)
4.	Injections
5.	Analgesia

Best Treatments:
Research Summary Report
on Tobacco Use Disorder

CureHunter Patient-Physician Summary Reports collect in one document all the medications ever reported in the US National Library of Medicine—1949 to the present—to be effective against your target disease. CureHunter research summary reports will vary in length from 25 to 250 pages. Analytic charts allow you and your physicians to see at a glance your medication options—including new, promising, off-label and experimental all rated for clinical efficacy.

Free Updates for 1 Year
All 75 Outcomes
Top 200 Key Drugs and Biologics
Top 23 Key Therapies and Procedures
Detailed History Charts
Full Research Reference Details
Sample PDF Report on Psoriasis >>

Price:

$24.00 & Delivery via PDF download
updates for 1 year

Research Interface

Rapidly retrieve summaries of all the evidence for any disease in seconds. Save hours of search and analysis time. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time.

Unlimited Disease, Drug and Therapy Search
2 clicks from Disease to Drug to Evidence
Trial References
All the Positive Outcomes
Detailed Relationship Timeline Charts
Full Article Reference Details
Includes Mobile Interface Subscription
One-click to FDA Products/Patents
Request Institution License Details >>

Price:

$490.00 access via web interface
1 year subscription

Proceed to Checkout >>

Mobile Interface

Retrieve summaries of all the evidence for any disease from your Mobile Phone or PDA. Accelerate decision making in the field. Speed up your study of new drug and disease domains. Refresh your knowledge on the road.

Access from any web enabled PDA or Phone
Trial references
All the Positive Outcomes
Drug and Therapy searches
Full Article Reference Details
Try Mobile Interface >>

Price:

$45.00 access via "curehunter.com/m"
1 year subscription

Proceed to Checkout >>