desformylflustrabromine

from marine bryozoan Flustra foliacea; structure in first source

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

1.	Pain (Aches) 03/07/2019 - "The aim of this study was to assess the effects of desformylflustrabromine on chemically induced pain. " 03/07/2019 - "These results suggest that desformylflustrabromine has the potential to become a clinically used drug for pain relief." 03/07/2019 - "Acute Administration of Desformylflustrabromine Relieves Chemically Induced Pain in CD-1 Mice."
2.	Neuralgia (Stump Neuralgia) 01/01/2022 - "Desformylflustrabromine (dFBr), a positive allosteric modulator of the α4β2 nAChRs has been shown to reduce nicotine intake, compulsive-like behavior and neuropathic pain in animal models. " 01/01/2018 - "Allosteric modulation of α4β2* nicotinic acetylcholine receptors: Desformylflustrabromine potentiates antiallodynic response of nicotine in a mouse model of neuropathic pain."
3.	Acquired Immunodeficiency Syndrome (AIDS) 01/01/2018 - "Unlike US Food and Drug administration approved smoke cessation aids (nicotine and varenicline) which act as nicotinic acetylcholine receptors (nAChRs) agonists, desformylflustrabromine (dFBr) acts as a nAChR positive allosteric modulator with higher selectivity to the α4β2 nAChR. "

1.	Nicotine
2.	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)
3.	Smoke
4.	Varenicline (Chantix)