Pertussis-associated persistent cough in previously vaccinated children.

Abstract

To evaluate the role of Bordetella pertussis infection, 96 otherwise healthy 7- to 17-year-old subjects who were suffering from a cough lasting from 2 to 8 weeks were prospectively recruited. At enrolment, a nasopharyngeal swab and an oral fluid sample were obtained to search for pertussis infection by the detection of B. pertussis DNA and/or an elevated titre of anti-pertussis toxin IgG. Evidence of pertussis infection was found in 18 (18.7 %; 95 % confidence interval, 11.5-28.0) cases. In 15 cases, the disease occurred despite booster administration. In two cases, pertussis was diagnosed less than 2 years after the booster injection, whereas in the other cases it was diagnosed between 2 and 9 years after the booster dose. This study used non-invasive testing to show that pertussis is one of the most important causes of long-lasting cough in school-age subjects. Moreover, the protection offered by acellular pertussis vaccines currently wanes more rapidly than previously thought.

• Authors: Nicola Principi, David Litt, Leonardo Terranova, Marina Picca, Concetta Malvaso, Cettina Vitale, Norman K Fry, Susanna Esposito, The Italian Pertussis Group For Persistent Cough In Children
• Journal: Journal of medical microbiology (J Med Microbiol) Vol. 66 Issue 11 Pg. 1699-1702 (11 2017) ISSN: 1473-5644 [Electronic] England
• PMID: 28984566 (Publication Type: Journal Article)

Chemical References

• Pertussis Vaccine

Topics

• Adolescent
• Child
• Cough (etiology)
• Female
• Humans
• Male
• Pertussis Vaccine (immunology)
• Whooping Cough (pathology, prevention & control)