1,6-O,O-Diacetylbritannilactone suppresses activation of mast cell and airway hyper-responsiveness.

Abstract	Mast cells play critical roles in allergic disorders such as atopic dermatitis and allergic asthma. The aim of this study was to investigate the anti-inflammatory and anti-asthmatic activities of 1,6-O,O-diacetylbritannilactone (OODBL) isolated from Inula japonica Thunb. (I. japonica) in a murine asthma model and bone marrow-derived mast cells (BMMCs). In an ovalbumin-induced asthma model, OODBL administration attenuated the airway hyper-responsiveness induced by aerosolized methacholine and serum IgE level in asthmatic mice. In vitro system, we found that OODBL reduced leukotriene C4 production and degranulation through the suppression of cytosolic phospholipase A2 phosphorylation and phospholipase Cγ-mediated Ca2+ influx in IgE/antigen-stimulated BMMCs. Taken together, OODBL may have therapeutic potential in the treatment of allergic diseases such as asthma.
Authors	Meihua Jin, Sungun Kim, Nan Qin, Xi Chen, Ning Ji, Sheng-An Tang, Dexin Kong, Eunkyung Lee, Hongquan Duan
Journal	Immunopharmacology and immunotoxicology (Immunopharmacol Immunotoxicol) Vol. 39 Issue 4 Pg. 173-179 (Aug 2017) ISSN: 1532-2513 [Electronic] England
PMID	28447503 (Publication Type: Journal Article)
Chemical References	Anti-Allergic Agents Anti-Asthmatic Agents Anti-Inflammatory Agents Lactones O, O-diacetylbritannilactone Sesquiterpenes Leukotriene C4 Immunoglobulin E Ovalbumin
Topics	Animals Anti-Allergic Agents (pharmacology) Anti-Asthmatic Agents (pharmacology) Anti-Inflammatory Agents (pharmacology) Asthma (chemically induced, drug therapy, metabolism) Bone Marrow Cells (drug effects, metabolism) Cell Degranulation (drug effects) Dermatitis, Atopic (chemically induced, drug therapy, metabolism) Disease Models, Animal Female Immunoglobulin E (metabolism) Lactones (pharmacology) Leukotriene C4 (metabolism) Mast Cells (drug effects, metabolism) Mice Mice, Inbred BALB C Ovalbumin (pharmacology) Phosphorylation (drug effects) Respiratory Hypersensitivity (chemically induced, drug therapy, metabolism) Sesquiterpenes (pharmacology) Signal Transduction (drug effects)

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