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Methacholine Chloride (Methacholine)

A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
Also Known As:
Methacholine; Provocholine; 2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminium Chloride; Acetyl-2-methylcholine Chloride; Acetyl-beta-methacholine Chloride; Acetyl-beta-methylcholine; Mecholine; Mecholyl; Provokit; Acetyl 2 methylcholine Chloride; Acetyl beta methacholine Chloride; Acetyl beta methylcholine; Chloride, Methacholine; 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride
Networked: 3535 relevant articles (144 outcomes, 392 trials/studies)

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Experts

1. Cockcroft, Donald W: 25 articles (01/2020 - 09/2004)
2. Boulet, Louis-Philippe: 24 articles (01/2020 - 08/2002)
3. Gelfand, Erwin W: 24 articles (01/2019 - 03/2002)
4. Takeda, Katsuyuki: 20 articles (01/2022 - 07/2002)
5. Davis, Beth E: 19 articles (01/2020 - 09/2004)
6. Fujimura, Masaki: 17 articles (10/2020 - 12/2002)
7. Weiss, Scott T: 16 articles (12/2019 - 06/2002)
8. Koh, Young Yull: 16 articles (03/2018 - 10/2002)
9. Postma, D S: 16 articles (04/2016 - 09/2000)
10. Joetham, Anthony: 15 articles (01/2019 - 03/2002)

Related Diseases

1. Asthma (Bronchial Asthma)
2. Respiratory Hypersensitivity
3. Inflammation (Inflammations)
4. Bronchial Spasm
5. Bronchial Hyperreactivity

Related Drugs and Biologics

1. Allergens
2. Adenosine Monophosphate (AMP)
3. Bronchodilator Agents (Bronchodilators)
4. Albuterol (Salbutamol)
5. Histamine (Histamine Dihydrochloride)
6. Adrenal Cortex Hormones (Corticosteroids)
7. Budesonide (Pulmicort)
8. Adenosine (Adenocard)
9. Immunoglobulin E (IgE)
10. Salmeterol Xinafoate (Serevent)

Related Therapies and Procedures

1. Therapeutics
2. Aftercare (After-Treatment)
3. Nebulizers and Vaporizers (Inhaler)
4. Kidney Transplantation
5. Radiation Dosimeters