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Rapid response of the steatosis-sensing hepatokine LECT2 during diet-induced weight cycling in mice.

Abstract
Dieting often leads to body weight cycling involving repeated weight loss and regain. However, little information is available regarding rapid-response serum markers of overnutrition that predict body weight alterations during weight cycling. Here, we report the rapid response of serum leukocyte cell-derived chemotaxin 2 (LECT2), a hepatokine that induces insulin resistance in skeletal muscle, during diet-induced weight cycling in mice. A switch from a high-fat diet (HFD) to a regular diet (RD) in obese mice gradually decreased body weight but rapidly decreased serum LECT2 levels within 10 days. In contrast, a switch from a RD to a HFD rapidly elevated serum LECT2 levels. Serum LECT2 levels showed a positive correlation with liver triglyceride contents but not with adipose tissue weight. This study demonstrates the rapid response of LECT2 preceding body weight alterations during weight cycling in mice and suggests that measurement of serum LECT2 may be clinically useful in the management of obesity.
AuthorsKeita Chikamoto, Hirofumi Misu, Hiroaki Takayama, Akihiro Kikuchi, Kiyo-Aki Ishii, Fei Lan, Noboru Takata, Natsumi Tajima-Shirasaki, Yumie Takeshita, Hirohiko Tsugane, Shuichi Kaneko, Seiichi Matsugo, Toshinari Takamura
JournalBiochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 478 Issue 3 Pg. 1310-6 (09 23 2016) ISSN: 1090-2104 [Electronic] United States
PMID27562717 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Biomarkers
  • Insulin
  • Intercellular Signaling Peptides and Proteins
  • Lect2 protein, mouse
Topics
  • Adipose Tissue (pathology)
  • Adiposity
  • Animals
  • Biomarkers (metabolism)
  • Body Weight
  • Diet, High-Fat
  • Disease Models, Animal
  • Fatty Liver (metabolism, pathology)
  • Insulin (blood)
  • Intercellular Signaling Peptides and Proteins (blood, metabolism)
  • Liver (metabolism, pathology)
  • Male
  • Mice, Inbred C57BL
  • Organ Size
  • Overnutrition (blood, pathology)

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