Overnutrition

An imbalanced NUTRITIONAL STATUS resulting from excessive intake of nutrients. Generally, overnutrition generates an energy imbalance between food consumption and energy expenditure leading to disorders such as OBESITY.

Also Known As:

Networked: 616 relevant articles (14 outcomes, 57 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Obesity
2.	Metabolic Syndrome (Dysmetabolic Syndrome X)
3.	Weight Loss (Weight Reduction)
4.	Malnutrition (Nutritional Deficiencies)
5.	Inflammation (Inflammations)

Experts

1.	Sowers, James R: 9 articles (01/2017 - 01/2011)
2.	Chowen, Julie A: 6 articles (01/2019 - 05/2011)
3.	Whaley-Connell, Adam: 6 articles (01/2017 - 01/2011)
4.	Dabelea, Dana: 5 articles (01/2022 - 10/2019)
5.	Williams, Kevin Jon: 5 articles (07/2021 - 06/2010)
6.	Morris, Margaret J: 5 articles (01/2021 - 06/2005)
7.	Kalantar-Zadeh, Kamyar: 5 articles (01/2021 - 04/2004)
8.	Argente, Jesús: 5 articles (01/2018 - 05/2011)
9.	DeMarco, Vincent G: 5 articles (01/2017 - 01/2011)
10.	Muhlhausler, B S: 5 articles (10/2012 - 12/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Overnutrition:

1.	Insulin (Novolin)FDA Link 03/01/2016 - "The aim of our study was to investigate the cardiac metabolism of weaned mice submitted to overnutrition during lactation, particularly as to mitochondrial function, substrate preference and insulin signaling. " 10/01/2021 - "Overnutrition in utero corresponded with 14% higher baseline fasting insulin (geometric mean ratio 1.14 [95% CI 1.01, 1.29]), even after controlling for VAT/SAT ratio. " 02/20/2021 - "Alterations of Gut Microbiota by Overnutrition Impact Gluconeogenic Gene Expression and Insulin Signaling." 01/01/2021 - "White adipose tissue (WAT) insulin action has critical anabolic function and is dysregulated in overnutrition. " 01/01/2019 - "Early overnutrition males exhibited higher β cell mass but reduced islet insulin content and Pdx1 expression. "
2.	Glucose (Dextrose)FDA LinkGeneric 01/01/2023 - "This study intends to investigate the impact of hepatic IDH2 expression on overnutrition-regulated glucose and lipid metabolism. " 02/01/1996 - "In the present study we have examined for the first time the combined effects of postnatal overnutrition and pregnancy on glucose homeostasis of rats treated neonatally with STZ. " 01/01/2021 - "We hypothesized that the healthier fat profile of the latter diet would improve early overnutrition-induced glucose dysregulation. " 01/01/2021 - "We also discuss imprinted genes in the context of the next generation, where dietary overnutrition in the parents can lead to their deregulation in the offspring, alongside beta cell dysfunction and defective glucose handling. " 01/01/2018 - "The role of developmental overnutrition related to maternal adiposity and circulating glucose in these ethnic differences is unclear. "
3.	LipidsIBA 07/01/2012 - "The aims of our study were to investigate effects of postnatal overnutrition, obtained by restricting the number of pups per litter, on microcirculatory reactivity, fat depots, its total percentage and lipid profile. " 01/01/2022 - "Long-term overnutrition results in excessive expansion and dysfunction of adipose tissue, inflammatory responses and over-accumulation of extracellular matrix in adipose tissue, and ectopic lipid deposit in other organs, termed adipose tissue remodeling. " 01/01/2022 - "These "overnutrition" diets also promote the accumulation of a variety of harmful lipids in the heart and other peripheral organs, known as lipotoxicity. " 01/01/2021 - "Hepatic MFGE8 deletion largely exacerbated lipid accumulation and inflammatory responses in the liver in response to overnutrition. " 01/01/2020 - "Tissue-specific analysis of lipid species in Drosophila during overnutrition by UHPLC-MS/MS and MALDI-MSI."
4.	LeptinIBA 05/06/2023 - "In sheep, the leptin surge is eliminated with maternal overnutrition and an elevated dam body condition score (BCS), but this has not been assessed in dairy cattle. " 01/01/2022 - "Previous studies reported that postnatal overnutrition increases leptin secretion during the pre-weaning period. " 01/01/2022 - "Early postnatal overnutrition causes metabolic alterations that can be permanently attenuated with the administration of a leptin antagonist during a restricted developmental window." 01/01/2022 - "However, a direct link between leptin, neonatal overnutrition, and lifelong metabolic regulation has not been investigated. " 08/13/2020 - "Postnatal overnutrition affects leptin secretion and sensitivity, but whether postnatal overnutrition produces changes in the development of the synaptic transmission to ARH neurons is currently unknown. "
5.	CarbohydratesIBA 04/01/1980 - "Except when energy expenditure level is very high they do not support a policy of routinely use hypernutrition with high carbohydrates diet." 12/01/2022 - "Maternal metabolic condition is considered a risk factor for adverse birth outcomes and long-term MS. In this study, we developed a rabbit model of maternal overnutrition via the chronic intake of a high-fat and carbohydrate diet (HFCD), and we determined the effects of this diet on maternal metabolism and offspring metabolic set points and temporal metabolic regulation in adult life. " 12/30/2021 - "Parental overnutrition by carbohydrates in developmental origins of metabolic syndrome." 01/01/2020 - "The SI is a target of prenatal nutritional programming, where late gestation overnutrition increased and shifted digestive capacity for carbohydrates toward the jejunum, whereas late gestation undernutrition predisposed for ileal angiogenesis and carbohydrate and fat hyperabsorptive capacity upon subsequent exposure to postnatal obesogenic diet." 08/01/2015 - "The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased worldwide in parallel with overnutrition characterized by high-fat and high-carbohydrate intake. "
6.	Serine (L-Serine)FDA Link 10/01/2017 - "Altogether, this study demonstrates that phosphorylation of p65 serine 467 augment NF-κB activity and exacerbates various deleterious effects of overnutrition in mice." 12/01/2012 - "On the other hand, phosphatase activation may also exert beneficial and cardiovascular protective effects in conditions such as overnutrition by blocking serine phosphorylation of IRS-1, thereby improving downstream INS metabolic signaling. "
7.	NebivololFDA Link 08/01/2012 - " CONCLUSION: We report for the first time that nebivolol regulates overnutrition-induced activation of cardiac mTOR and Jak/STAT signaling and reverses suppression of AMPK. " 08/01/2012 - " METHODS: Young Zucker obese (ZO) rats, a rodent model for overnutrition, and age-matched Zucker lean rats were treated with nebivolol (10 mg/kg/day; 21 days) and cardiac function was monitored by echocardiography and pressure volume loop analysis. " 08/01/2012 - "Since it also suppresses weight gain, nebivolol appears effective in the treatment of overnutrition-related cardiac inflammation and diastolic dysfunction." 08/01/2012 - "Objective: The objective of this study was to determine whether nebivolol regulates overnutrition-induced activation of cardiac nutrient sensor kinases and inflammatory signaling. "
8.	Insulin-Like Growth Factor I (IGF-1)IBA 01/01/2012 - "It has long been known to be dysregulated in states of under- and overnutrition, serum IGF-I levels falling in malnourished patients and responding promptly to nutritional support. " 04/01/1998 - "In conclusion, it can be hypothesized that the overnutrition causes hyperinsulinemia which increases GH receptor and IGF-I secretion despite low GH secretion. " 12/01/1992 - "In children, overnutrition decreases GH and increases IGF-I, while undernutrition decreases IGF-I and increases GH. " 07/01/2000 - "GH receptor deficiency leads to a marked decrease in circulating IGF-I. Hypernutrition and hyperinsulinism of obesity directly promote hepatic IGF-I release and inhibit GH secretion by the pituitary. " 02/15/2015 - "This mini-review will discuss the role of IGF-1 signaling cascade in the prevalence of metabolic syndrome in particular the susceptibility to overnutrition and sedentary life style-induced obesity, dyslipidemia, insulin resistance and other features of metabolic syndrome. "
9.	ChitosanIBA 04/04/2012 - "The parameters of high-fat diet-induced rats indicated that chitosan and its two derivatives not only have low cytotoxicity but can control overnutrition by fat and achieve insulin resistance therapy. " 01/01/2021 - "Chitosan Oligosaccharide Ameliorates Metabolic Syndrome Induced by Overnutrition via Altering Intestinal Microbiota."
10.	Polysaccharides (Glycans)IBA 01/01/2019 - "Thereafter, and the "polysaccharides-gut microbiota" is put forward for polysaccharides to exhibit their antitumor activity, which may attribute to the improved leaky gut, avoided hypernutrition, and reinforced immune homeostasis, finally creating a systemic environment to lower the risks of tumor."

Therapies and Procedures

1.	Therapeutics 12/01/2022 - "In this study, the magnitude of overnutrition is high associated with a viral load of fewer than 1000 copies/cell, age greater than 45, and having taken prophylaxis therapy. " 12/01/2022 - "Anti-retroviral therapy was introduced to treat human immunodeficiency virus patients; comorbidities affecting individuals with human immunodeficiency virus-positive have changed dramatically, with increasing the prevalence of overnutrition. " 12/01/2022 - "Overnutrition and its associated factors among adult human immunodeficiency virus positive patients on antiretroviral therapy, Northwest, Ethiopia." 01/01/2018 - "This new HCC model provides a relatively rapid means of examining primary HCC and potential therapies in the context of multiple hepatotoxins including those derived from overnutrition." 11/01/2011 - "From a clinical point of view, avoidance of materno-fetal overnutrition, universal diabetes screening in all pregnant women and adequate therapy of all forms of diabetes during pregnancy, as well as avoidance of neonatal overfeeding are therefore recommended. "
2.	Hyperbaric Oxygenation 01/01/2008 - "Tapering of PSL, administration of intravenous cyclophosphamide, prokinetic agents and antibiotics, bowel rest with intravenous hypernutrition therapy and hyperbaric oxygen therapy successfully improved PCI. "
3.	Caloric Restriction 01/01/2017 - "The present study addressed this question by the preliminary examination of the transcriptional dynamics in skeletal muscle after exposure to overnutrition and following caloric restriction. " 01/01/2018 - "Caloric restriction is difficult to affect clinically, therefore, dietary interventions that ameliorate the adverse consequences of overnutrition in the presence of a high-calorie diet would be of value. " 10/01/2013 - "Adult-onset obesity induced by early life overnutrition could be reversed by moderate caloric restriction." 07/01/2010 - "Advances in the molecular biology of ageing, insulin resistance, inflammation, carcinogenesis and caloric restriction have elucidated commonalities relevant to the chronic overnutrition syndrome termed obesity. " 11/01/2009 - "The state of enzymatic antioxidant system and thyroid status in the rat tissues under early postnatal overnutrition leading to shortening of life-span and calorie-restricted diet extending lifespan have been studied. "
4.	Critical Care (Surgical Intensive Care) 07/29/2019 - "In line with this, earlier trials in the intensive care setting including severely ill patients have demonstrated unwarranted effects of overnutrition on patient outcomes. "
5.	Fecal Microbiota Transplantation 01/01/2021 - "Indeed, fecal transplant studies show that microbiota transfer from undernourished and overnourished humans to germ-free mice lacking a microbiome transfers the physical and metabolic phenotype, suggesting a causal role for the microbiota in under- and overnutrition. "