T cell immunoglobulin and mucin domain-containing molecule 3 on CD14+ monocytes serves as a novel biological marker for diabetes duration in type 2 diabetes mellitus.

Abstract

AIMS/INTRODUCTION:

Type 2 diabetes is a worldwide disease that is associated with increased rates of obesity and reduced physical activity. Obesity-associated insulin resistance in type 2 diabetes is a disorder in the balance between pro-inflammatory and anti-inflammatory signals. T cell immunoglobulin and mucin domain-containing molecule 3 (Tim-3) has been reported as an important regulatory inflammation molecule, and plays a pivotal role in several inflammation-related diseases.

MATERIALS AND METHODS:

Peripheral blood mononuclear cells were obtained from type 2 diabetes patients (n = 31) and healthy donors (n = 18), and Tim-3 expression on peripheral blood mononuclear cells was evaluated by flow cytometry.

RESULTS:

We showed the downregulated expression of Tim-3 on CD14+ monocytes from type 2 diabetes patients. In addition, the upregulated expression of Tim-3 on peripheral CD4+ T cells and CD8+ T cells was observed in the present study. The correlation analysis between Tim-3 expression on CD14+ monocytes and diabetes duration showed the longer diabetes duration time, the lower Tim-3 expression on CD14 monocytes.

CONCLUSIONS:

The present results suggest that Tim-3 might participate in the progression of type 2 diabetes by its negative regulation on these immune cells, and Tim-3 on CD14+ monocytes serves as a novel biological marker for diabetes duration in type 2 diabetes patients.

• Authors: Wen-Jiang Yan, Peng Sun, Dan-Dan Wei, Shuang-Xi Wang, Jing-Jing Yang, Yi-Hui Li, Cheng Zhang
• Journal: Journal of diabetes investigation (J Diabetes Investig) Vol. 7 Issue 6 Pg. 867-873 (Nov 2016) ISSN: 2040-1124 [Electronic] Japan
• PMID: 27182056 (Publication Type: Journal Article)
• Copyright: © 2016 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.

Chemical References

• Biomarkers
• CD4 Antigens
• CD8 Antigens
• HAVCR2 protein, human
• Hepatitis A Virus Cellular Receptor 2
• Lipopolysaccharide Receptors

Topics

• Adult
• Aged
• Biomarkers (metabolism)
• CD4 Antigens (metabolism)
• CD8 Antigens (metabolism)
• Diabetes Mellitus, Type 2 (diagnosis, immunology, metabolism)
• Disease Progression
• Female
• Hepatitis A Virus Cellular Receptor 2 (metabolism)
• Humans
• Lipopolysaccharide Receptors (metabolism)
• Male
• Middle Aged
• Monocytes (metabolism)