Abstract | BACKGROUND: Adhesion formation, which results from mechanical peritoneal damage, tissue ischemia, or the presence of foreign materials, is a complicated process. The formation of adhesions is associated with inflammatory response and extracellular matrix deposition in response to injury. Although the pathophysiology of adhesion formation is widely understood, an absolute solution to this problem does not exist yet. As a main component of Erigeron breviscapus, breviscapine has exhibited the ability of anti-inflammatory and antifibrosis on many diseases. The purpose of this study was to investigate the effect of breviscapine on the development of postoperative intra-abdominal adhesions in Wistar rats. METHODS: RESULTS: CONCLUSIONS: These results suggested that intraperitoneal administration of breviscapine was effective in preventing intra-abdominal adhesion formation in rats. Breviscapine appears to have synergetic effects which could decrease fibrosis by inhibiting inflammation, upregulating peritoneal fibrinolytic activity and regulating the TGF and/or Smad signaling pathway. These data indicated a potential new therapeutic use of breviscapine on adhesion prevention.
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Authors | Hui Zhang, Yu Song, Zhiyong Li, Ting Zhang, Li Zeng |
Journal | American journal of surgery
(Am J Surg)
Vol. 211
Issue 6
Pg. 1143-52
(Jun 2016)
ISSN: 1879-1883 [Electronic] United States |
PMID | 26394920
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Chemical References |
- Flavonoids
- Interleukin-18
- Interleukin-6
- Transforming Growth Factor beta1
- breviscapine
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Topics |
- Abdomen
(surgery)
- Animals
- Biopsy, Needle
- Blotting, Western
- Disease Models, Animal
- Enzyme-Linked Immunosorbent Assay
- Female
- Flavonoids
(pharmacology)
- Immunohistochemistry
- Injections, Intraperitoneal
- Interleukin-18
(metabolism)
- Interleukin-6
(metabolism)
- Male
- Random Allocation
- Rats
- Rats, Wistar
- Reference Values
- Sensitivity and Specificity
- Statistics, Nonparametric
- Tissue Adhesions
(pathology, prevention & control)
- Transforming Growth Factor beta1
(metabolism)
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