Abstract | BACKGROUND: There is growing evidence that natural products, mostly plant-derived polyphenols, are important in the relationship between nutrients and health in humans. PURPOSE: We aimed to investigate if verbascoside (VB) and other lemon verbena polyphenols could ameliorate obesity-induced metabolic disturbances, as well as their putative mechanism. STUDY DESIGN: We used an insulin-resistant hypertrophic 3T3-L1-adipocyte model to test the effects of VB or lemon verbena extract on triglyceride accumulation, inflammation and oxidative stress and a murine model of diet-induced obesity to assess the in vivo metabolic response. RESULTS: CONCLUSION: Decreased lipogenesis, enhanced fatty acid oxidation and the activation of the energy sensor AMPK, probably through activating transcriptional factors, are involved in the observed beneficial effects. VB effects were less potent than those observed with the extract, so a potential synergistic, multi-targeted action is proposed. The polypharmacological effects of plant-derived polyphenols from lemon verbena may have the potential for clinical applications in obesity.
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Authors | María Herranz-López, Enrique Barrajón-Catalán, Antonio Segura-Carretero, Javier A Menéndez, Jorge Joven, Vicente Micol |
Journal | Phytomedicine : international journal of phytotherapy and phytopharmacology
(Phytomedicine)
Vol. 22
Issue 6
Pg. 605-14
(Jun 01 2015)
ISSN: 1618-095X [Electronic] Germany |
PMID | 26055125
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 Elsevier GmbH. All rights reserved. |
Chemical References |
- Adiponectin
- NF-kappa B
- PPAR gamma
- Plant Extracts
- Polyphenols
- Reactive Oxygen Species
- Fatty Acid Synthase, Type I
- AMP-Activated Protein Kinases
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Topics |
- 3T3-L1 Cells
- AMP-Activated Protein Kinases
(metabolism)
- Adipocytes
(drug effects)
- Adiponectin
(metabolism)
- Animals
- Fatty Acid Synthase, Type I
(metabolism)
- Humans
- Lipid Metabolism
- Lippia
(chemistry)
- Male
- Membrane Potential, Mitochondrial
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- NF-kappa B
(metabolism)
- Obesity
(drug therapy, physiopathology)
- PPAR gamma
(metabolism)
- Plant Extracts
(pharmacology)
- Polyphenols
(pharmacology)
- Promoter Regions, Genetic
- Reactive Oxygen Species
(metabolism)
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