Abstract | OBJECTIVE: METHODS: RESULTS: We found that 40% (38/94) of the patients with hypertension (HT) had no diastolic dysfunction (HTDD-), and 60% (56/94) had diastolic dysfunction (HTDD+). Compared to the controls, both patient groups had increased PC and BH4, TNF-α, PAI-I and BNP levels, while the HTDD+ group had elevated cGA and CRP levels. Decreased atrial and longitudinal left ventricular (LV) systolic and diastolic myocardial deformation (strain and strain rate) was demonstrated in both patient groups versus the control. Patients whose LV diastolic function deteriorated during the follow-up had elevated PC and IL-6 level compared to their own baseline values, and to the respective values of patients whose LV diastolic function remained unchanged. Oxidative stress, inflammation, BNP and PAI-I levels inversely correlated with LV systolic, diastolic and atrial function. CONCLUSIONS: In patients with HT and normal EF, the most common HFPEF precursor condition, oxidative stress and inflammation may be responsible for LV systolic, diastolic and atrial dysfunction, which are important determinants of the transition of HT to HFPEF.
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Authors | Zsuzsanna Szelényi, Ádám Fazakas, Gábor Szénási, Melinda Kiss, Narcis Tegze, Bertalan Csaba Fekete, Eszter Nagy, Imre Bodó, Bálint Nagy, Attila Molvarec, Attila Patócs, Lilla Pepó, Zoltán Prohászka, András Vereckei |
Journal | Journal of geriatric cardiology : JGC
(J Geriatr Cardiol)
Vol. 12
Issue 1
Pg. 1-10
(Jan 2015)
ISSN: 1671-5411 [Print] China |
PMID | 25678898
(Publication Type: Journal Article)
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