Abstract | BACKGROUND: OBJECTIVE: SUBJECTS: Patients' age at diagnosis ranged from 5.0 to 16.5 years. Two (2) patients had Turner syndrome, another one (1), diabetic, was on insulin therapy. RESULTS: In all the girls, antithyroid drugs were administered and euthyroid state was achieved during the first 2.0-3.5 months of the treatment. Mild side effects were observed in only one case. The therapy was continued up to 1.5-4.0 years. Relapses during the therapy were observed in 2 cases. Up to now, no relapses have been observed for 0.5-7.5 years since the therapy withdrawal in 5 patients (1 patient was lost to follow-up), 2 patients are currently treated with levothyroxine due to hypothyroidism. CONCLUSIONS: It seems that the prolonged pharmacotherapy with antithyroid drugs, followed by observation after remission of hyperthyroidism, may be an appropriate therapeutic option at least in some children with GD as they can be cured without radical therapy and the potential risks of such treatment.
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Authors | Joanna Smyczńyska, Anna Cyniak-Magierska, Magdalena Stasiak, Małgorzata Karbownik-Lewińska, Andrzej Lewiński |
Journal | Neuro endocrinology letters
(Neuro Endocrinol Lett)
Vol. 35
Issue 5
Pg. 335-41
( 2014)
ISSN: 0172-780X [Print] Sweden |
PMID | 25275265
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antithyroid Agents
- Autoantibodies
- Receptors, Thyrotropin
- Methimazole
- Propylthiouracil
- Thyrotropin
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Topics |
- Adolescent
- Antithyroid Agents
(administration & dosage, adverse effects)
- Autoantibodies
(immunology)
- Child
- Child, Preschool
- Female
- Graves Disease
(drug therapy, immunology)
- Hashimoto Disease
(drug therapy, immunology)
- Humans
- Hypothyroidism
(chemically induced)
- Male
- Methimazole
(administration & dosage, adverse effects)
- Propylthiouracil
(administration & dosage, adverse effects)
- Receptors, Thyrotropin
(immunology)
- Remission Induction
- Thyrotropin
(immunology)
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