Abstract | OBJECTIVES: METHODS AND MATERIALS: We retrospectively evaluated 327 patients with MIBC who underwent RC from 1996 to 2013 at a single institution. Serum BChE level was routinely measured before operation in all patients. Covariates included age, gender, preoperative laboratory data ( anemia, BChE, lactate dehydrogenase, and C-reactive protein), clinical T (cT) and N stage (cN), tumor grade, and RC with/without neoadjuvant chemotherapy. Univariate and multivariate analyses were performed to identify clinical factors associated with overall survival (OS) and disease-free survival (DFS). Univariate analyses were performed using the Kaplan-Meier and log-rank methods, and the multivariate analysis was performed using a Cox proportional hazard model. RESULTS: The median BChE level was 187 U/l (normal range: 168-470 U/l). The median age of the enrolled patients was 69 years, and the median follow-up period was 51 months. The 5-year OS and DFS rates were 69.6% and 69.3%, respectively. The 5-year OS rates were 90.1% and 51.3% in the BChE ≥ 168 and<168 U/l groups, respectively (P<0.001). The 5-year DFS rates were 83.5% and 55.4% in the BChE ≥ 168 and ≤167 U/l groups, respectively (P<0.001). In the univariate analysis, BChE, cT, cN, and RC with/without neoadjuvant chemotherapy were significantly associated with both OS and DFS. Multivariate analysis revealed that BChE was the factor most significantly associated with OS, and BChE, cT, and cN were significantly associated with DFS. CONCLUSIONS: This study validated preoperative serum BChE levels as an independent prognostic factor for MIBC after RC.
|
Authors | Takuya Koie, Chikara Ohyama, Hayato Yamamoto, Shingo Hatakeyama, Atsushi Imai, Takahiro Yoneyama, Yasuhiro Hashimoto, Masato Kitayam, Kazuyoshi Hirota |
Journal | Urologic oncology
(Urol Oncol)
Vol. 32
Issue 6
Pg. 820-5
(Aug 2014)
ISSN: 1873-2496 [Electronic] United States |
PMID | 24951323
(Publication Type: Journal Article)
|
Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Butyrylcholinesterase
(blood)
- Chemotherapy, Adjuvant
- Combined Modality Therapy
- Cystectomy
(methods)
- Female
- Follow-Up Studies
- Humans
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Multivariate Analysis
- Muscles
(pathology)
- Neoadjuvant Therapy
- Neoplasm Invasiveness
- Predictive Value of Tests
- Preoperative Period
- Prognosis
- Retrospective Studies
- Treatment Outcome
- Urinary Bladder Neoplasms
(drug therapy, pathology, surgery)
|