Abstract | BACKGROUND: The renin-angiotensin-aldosterone system (RAAS) plays pivotal roles in the pathogenesis of chronic kidney disease (CKD) progression. Aliskiren, a direct renin inhibitor, inhibits the rate-limiting step of the RAAS without any alternative pathway. It is proven to reduce albuminuria in CKD patients treated with angiotensin blockade. However, there are few reports which evaluate the advantage of aliskiren as the first-line drug against CKD progression in RAAS-activated hypertensive patients. METHODS: Tsukuba hypertensive mice (THM), double transgenic mice carrying both the human renin and human angiotensinogen genes, were fed a high- salt diet and treated with hydraladine, ramipril and aliskiren for 10 weeks. Blood pressure and urinary albumin excretion were measured every 2 weeks during the experimental period. We evaluated renal histological changes and gene expression. Plasma angiotensin concentration was measured to evaluate the RAAS inhibitory effect. RESULTS: CONCLUSION:
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Authors | Shigetaka Yoshida, Kenichi Ishizawa, Nobuhiro Ayuzawa, Kohei Ueda, Maki Takeuchi, Wakako Kawarazaki, Toshiro Fujita, Miki Nagase |
Journal | Clinical and experimental nephrology
(Clin Exp Nephrol)
Vol. 18
Issue 4
Pg. 593-9
(Aug 2014)
ISSN: 1437-7799 [Electronic] Japan |
PMID | 24154707
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- AGT protein, human
- Amides
- Angiotensin-Converting Enzyme Inhibitors
- Antihypertensive Agents
- Fumarates
- Sodium Chloride, Dietary
- Angiotensinogen
- Angiotensin II
- Hydralazine
- aliskiren
- Angiotensin I
- Renin
- Ramipril
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Topics |
- Albuminuria
(drug therapy, metabolism)
- Amides
(pharmacology)
- Angiotensin I
(blood)
- Angiotensin II
(blood)
- Angiotensin-Converting Enzyme Inhibitors
(pharmacology)
- Angiotensinogen
(genetics, metabolism)
- Animals
- Antihypertensive Agents
(pharmacology)
- Blood Pressure
(drug effects)
- Cytoprotection
- Disease Models, Animal
- Disease Progression
- Down-Regulation
- Fumarates
(pharmacology)
- Humans
- Hydralazine
(pharmacology)
- Hypertension
(blood, drug therapy, genetics, pathology, physiopathology)
- Kidney
(drug effects, metabolism, pathology, physiopathology)
- Kidney Diseases
(blood, genetics, pathology, physiopathology, prevention & control)
- Mice
- Mice, Transgenic
- Ramipril
(pharmacology)
- Renin
(antagonists & inhibitors, genetics, metabolism)
- Renin-Angiotensin System
(drug effects, genetics)
- Sodium Chloride, Dietary
- Time Factors
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