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Angiotensin I

A decapeptide that is cleaved from precursor angiotensinogen by RENIN. Angiotensin I has limited biological activity. It is converted to angiotensin II, a potent vasoconstrictor, after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME.
Networked: 449 relevant articles (15 outcomes, 46 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Chakraborty, Kajal: 4 articles (11/2022 - 12/2021)
2. Chen, Xiaofeng: 3 articles (01/2020 - 09/2013)
3. Daugherty, Alan: 3 articles (01/2020 - 09/2013)
4. Bernstein, Kenneth E: 3 articles (10/2018 - 02/2008)
5. Fuchs, Sebastien: 3 articles (10/2018 - 02/2008)
6. Borchers, Christoph H: 3 articles (01/2017 - 10/2010)
7. Irigoyen, Maria Claudia: 3 articles (12/2012 - 01/2010)
8. Hong, Fang: 3 articles (04/2011 - 06/2008)
9. Campbell, Duncan J: 3 articles (02/2009 - 10/2004)
10. Francis, Prima: 2 articles (08/2022 - 12/2021)

Related Diseases

1. Hypertension (High Blood Pressure)
2. Essential Hypertension
3. Heart Failure
4. Diabetic Nephropathies (Diabetic Nephropathy)
10/01/1992 - "In preliminary data from a comparison between individuals with and without diabetic nephropathy, no DNA sequence difference in that part of the angiotensinogen gene that codes for angiotensin I was found. "
01/01/2022 - "Renin-angiotensin-aldosterone system plays important roles in the development of diabetic nephropathy (DN), and angiotensin converting enzyme (ACE) is the key factor in the process from angiotensin I to angiotensin II, but the variation and roles of serum ACE in DN patients are still unclear. "
12/01/2008 - "Angiotensin converting enzyme (ACE) generates angiotensin II from angiotensin I, which plays a critical role in the pathophysiology of diabetic nephropathy. "
10/01/2018 - "Studies have also shown that ACE has roles in inflammation and the immune response that are independent of angiotensin II. ACE's two catalytically independent domains, the N- and C-domains, can process a variety of substrates other than angiotensin I. To examine the relative contributions of each ACE domain to the sodium retentive state, renal inflammation, and renal injury associated with diabetic kidney disease, we used streptozotocin to induce diabetes in wild-type mice and in genetic mouse models lacking either a functional ACE N-domain (NKO mice) or C-domain (CKO mice). "
01/01/2004 - "Angiotensin converting enzyme (ACE) inhibitors, which block the formation of angiotensin II from the inactive angiotensin I, are widely used as first line treatment in hypertension, heart failure and diabetic nephropathy. "
5. Hypertrophy

Related Drugs and Biologics

1. Angiotensin II
2. Renin
3. Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
4. Captopril (Capoten)
5. aliskiren
6. Renin Inhibitors
7. Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
8. Enzymes
9. Irbesartan
10. Vasoconstrictor Agents

Related Therapies and Procedures

1. Therapeutics
2. Nephrectomy
3. Peritoneal Dialysis
4. Intravenous Infusions
5. Denervation