Angiotensinogen

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1113 relevant articles (9 outcomes, 189 trials/studies) found for this Bio-Agent

Description: An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver and secreted into blood circulation. Angiotensinogen is the inactive precursor of natural angiotensins. Upon successive enzyme cleavages, angiotensinogen yields angiotensin I, II, and III with amino acids numbered at 10, 8, and 7, respectively.

Also Known As:

Proangiotensin; Renin Substrate Tetradecapeptide; Renin Substrate; Tetradecapeptide, Renin Substrate; Hypertensinogen; Renin-Substrate; Angiotensinogen (protein renin substrate)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kumar, Ashok: 6 articles (12/2006 - 09/2002)
2.	Kobori, Hiroyuki: 5 articles (08/2008 - 01/2003)
3.	Tybjaerg-Hansen, Anne: 4 articles (06/2008 - 05/2002)
4.	Ganten, Detlev: 4 articles (10/2006 - 06/2002)
5.	Jain, Sudhir: 4 articles (01/2006 - 09/2002)
6.	Sethi, Amar A: 3 articles (06/2008 - 05/2002)
7.	Nordestgaard, Børge G: 3 articles (06/2008 - 05/2002)
8.	Qiu, C: 3 articles (02/2008 - 06/2000)
9.	Ozawa, Yuri: 3 articles (06/2007 - 05/2004)
10.	Lalouel, Jean-Marc: 3 articles (03/2007 - 03/2004)

Related Diseases

1.	Hypertension (High Blood Pressure) 06/01/1997 - "Covariate analysis revealed an independent relationship between the M235T genotype and systolic, diastolic, and mean ambulatory BP. Ambulatory monitoring improved the analytic power of our study and allowed detection of a clear and consistent relationship between angiotensinogen polymorphism and hypertension with a relatively small sample size." 01/01/1993 - "For example, recent linkage and association studies have raised the possibility that a blood pressure regulatory locus may exist in or near the angiotensinogen gene on chromosome 1. Detailed genetic experiments in animal models of hypertension may help to guide further clinical studies and lead to an improved understanding of gene action in the pathogenesis of essential hypertension." 12/01/2007 - "The C-532T polymorphism of the angiotensinogen gene is associated with pulse pressure: a possible explanation for heterogeneity in genetic association studies of AGT and hypertension." 12/01/2005 - "Several studies have shown an association between single nucleotide polymorphisms (SNPs) in the angiotensinogen (AGT) gene and hypertension. " 05/01/2005 - "2. The renin-angiotensin system plays an important role in the regulation of blood pressure and previous studies have suggested that angiotensinogen (AGT) gene locus is linked with human essential hypertension. " Order ALL the reference details at left...
2.	Anoxia (Hypoxia) 02/25/2000 - "In the present study, the effect of chronic hypoxia on the expression of RAS components, particularly at the levels of its precursor angiotensinogen and its receptor subtypes AT(1) and AT(2), were investigated in the rat pancreas. " 01/12/2001 - "Chronic hypoxia induced down-regulation of angiotensinogen expression in rat epididymis." 02/25/2000 - "Results from western blot and semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) analyses unequivocally showed that chronic hypoxia caused a marked increase in angiotensinogen both at the protein and gene levels when compared with that in the normoxic pancreas. " 01/12/2001 - "Results from RT-PCR analysis demonstrated that chronic hypoxia caused a marked decrease (60%) in the expression of angiotensinogen mRNA, when compared with that in the normoxic epididymis. " 01/12/2001 - "The presence of an intrinsic renin-angiotensin system (RAS) in the rat epididymis has been previously established by showing the expression of several key RAS components, and in particular angiotensinogen, the indispensable element for the intracellular generation of angiotensin II. In this study, the possible involvement of this local epididymal RAS in the testicular effects of chronic hypoxia was investigated. " Order ALL the reference details at left...
3.	Inflammation 01/01/1989 - "Studies were carried out to know whether the rise in plasma angiotensinogen is actually involved in the activity of the renin-angiotensin system during acute inflammation. " 08/01/2002 - "Enhanced angiotensinogen production, in turn, supplies more substrate to the activated vascular RAS, where locally produced Ang II synergizes with oxidized lipid to perpetuate atherosclerotic vascular inflammation. " 03/01/1993 - "We have, therefore, examined plasma concentrations and hepatic secretion of angiotensinogen in two widely used inflammation models, i.e. " 01/07/1993 - "The concentration of plasma angiotensinogen increases upon induction of inflammation. " 09/01/1991 - "Induction of acute inflammation in rats by injection of lipopolysaccharide caused about a 7-fold increase of urinary angiotensinogen excretion in the 24 hr after injection, with a concomitant elevation of plasma angiotensinogen. " Order ALL the reference details at left...
4.	Body Weight (Weight, Body) 11/17/2005 - "ASrAogen animals had lower body weights throughout the study, similar to reports for animals with systemic knockout of angiotensinogen or treated long term with renin-angiotensin system (RAS) blockers. " 09/01/2002 - "BACKGROUND: The objective of the study was to analyze the relationship of polymorphisms of the angiotensinogen gene with changes in body weight during 3 y of antihypertensive treatment, in a group of young adults with essential hypertension. " 11/01/2002 - "We studied the influence of age, body weight, total body fat content, anatomical localization, and diet on the expression of angiotensinogen (AGT) and angiotensin II type 1 (AT 1 )-receptor genes in white adipose tissue of normal and postnatal overfed rats. " 07/01/2000 - "Body weight correlated independently and positively with adipose angiotensinogen mRNA expression after adjusting for differences in age and height. " 09/01/1997 - "In order to fulfill this goal, blood pressure (BP), plasma renin activity (PRA) and plasma angiotensinogen concentration (PAoC) as well as haematocrit (Htc) and body weight (BW) of intact and post-puberal castrated normotensive (Nt) and hypertensive (Ht) rats of both sexes were studied following an experimental design similar to that of previous works. " Order ALL the reference details at left...
5.	Obesity 10/01/2009 - "In humans, body fat is correlated with levels of angiotensinogen, a precursor of Ang-II. Thus, the treatment of obesity could be improved through the use of substances that interfere with Ang-II." 10/01/2002 - "As obesity is a common finding in diabetic individuals, and obesity has been linked to an increase in plasma angiotensinogen levels, we enrolled diabetic subjects with a wide range of body mass index (BMI) for this study. " 08/01/2009 - "In addition, interactions among angiotensinogen, fat mass and obesity associated gene, GNB3, and uncoupling protein 3 genes were found in a significant four-locus generalized multifactor dimensionality reduction model among the obese population (p = 0.001). " 06/01/2004 - "Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity." 05/01/2004 - "RECENT FINDINGS: The components of the renin-angiotensin system are fully represented in the adipose tissue and appear to be upregulated in obesity--a condition associated with enhanced circulating angiotensinogen levels. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
2.	Messenger RNA (mRNA)
3.	Angiotensins
4.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
5.	Renin
6.	Endothelins (Endothelin)
7.	candesartan
8.	eplerenone (Inspra)
9.	bosentan (Tracleer)
10.	Angiotensin II

Related Therapies and Procedures

1.	Kidney Transplantation
2.	Ligation
3.	Heart Transplantation (Grafting, Heart)
4.	Percutaneous Coronary Transluminal Angioplasty (PTCA)
5.	Nephrectomy

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