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Renin

A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19.
Also Known As:
Big Renin; Cryorenin; Inactive Renin; Pre-Prorenin; Preprorenin; Prorenin; Angiotensin Forming Enzyme; Pre Prorenin; Renin, Big; Renin, Inactive; Angiotensin-Forming Enzyme; Angiotensinogenase
Networked: 12564 relevant articles (407 outcomes, 1242 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Danser, A H Jan: 39 articles (01/2022 - 02/2002)
2. Ichihara, Atsuhiro: 32 articles (01/2022 - 02/2002)
3. Itoh, Hiroshi: 28 articles (01/2022 - 03/2002)
4. Mulatero, Paolo: 26 articles (01/2022 - 12/2002)
5. Stowasser, Michael: 26 articles (01/2022 - 02/2002)
6. Rossi, Gian Paolo: 25 articles (01/2022 - 05/2002)
7. Calhoun, David A: 23 articles (01/2020 - 12/2002)
8. Ferrario, Carlos M: 21 articles (04/2022 - 01/2002)
9. Bader, Michael: 21 articles (01/2022 - 02/2002)
10. Nishiyama, Akira: 21 articles (01/2020 - 02/2002)

Related Diseases

1. Hypertension (High Blood Pressure)
2. Heart Failure
3. Essential Hypertension
4. Hyperaldosteronism (Conn Syndrome)
5. Renal Artery Obstruction (Renal Artery Stenosis)

Related Drugs and Biologics

1. Aldosterone
2. Angiotensins
3. Captopril (Capoten)
4. Sodium
5. Angiotensin II
6. Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
7. aliskiren
8. Norepinephrine (Noradrenaline)
9. Diuretics
10. Spironolactone (Aldactone)

Related Therapies and Procedures

1. Therapeutics
2. Nephrectomy
3. Adrenalectomy
4. Aftercare (After-Treatment)
5. Length of Stay