Markers of inflammation and bone remodelling associated with improvement in clinical response measures in psoriatic arthritis patients treated with golimumab.

Abstract

OBJECTIVE:

To determine serum biomarker associations with clinical response to golimumab treatment in patients with psoriatic arthritis (PsA).

METHODS:

GO-REVEAL was a randomised, placebo-controlled study of golimumab in patients with active PsA. Samples were collected from 100 patients at baseline, week 4 and week 14, and analysed for serum-based biomarkers and protein profiling (total 92 markers); data were correlated with clinical measures at week 14.

RESULTS:

Serum levels of a subset of proteins (apolipoprotein C III, ENRAGE, IL-16, myeloperoxidase, vascular endothelial growth factor, pyridinoline, matrix metalloproteinase 3, C-reactive protein (CRP), carcinoembryonic antigen, intercellular adhesion molecule 1 and macrophage inflammatory protein 1α) at baseline or week 4 were strongly associated with American College of Rheumatology 20% improvement (ACR20) response and/or disease activity score in 28 joints (DAS28) at week 14. A smaller subset of proteins was significantly associated with a 75% improvement in the psoriasis area and severity index score (PASI75) at week 14, (adiponectin, apolipoprotein CIII, serum glutamic oxaloacetic transaminase, and tumour necrosis factor α). Subsets of proteins were identified as potentially predictive of clinical response for each of the clinical measures, and the power of these biomarker panels to predict clinical response to golimumab treatment was stronger than for CRP alone.

CONCLUSIONS:

This analysis provides insight into several panels of markers that may have utility in identifying PsA patients likely to have ACR20, DAS28, or PASI75 responses following golimumab treatment.

• Authors: Carrie L Wagner, Sudha Visvanathan, Michael Elashoff, Iain B McInnes, Philip J Mease, Gerald G Krueger, Frederick T Murphy, Kim Papp, Juan J Gomez-Reino, Michael Mack, Anna Beutler, Dafna Gladman, Arthur Kavanaugh
• Journal: Annals of the rheumatic diseases (Ann Rheum Dis) Vol. 72 Issue 1 Pg. 83-8 (Jan 2013) ISSN: 1468-2060 [Electronic] England
• PMID: 22975755 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Antirheumatic Agents
• Biomarkers
• golimumab

Topics

• Adult
• Antibodies, Monoclonal (therapeutic use)
• Antirheumatic Agents (therapeutic use)
• Arthritis, Psoriatic (blood, drug therapy)
• Biomarkers (blood)
• Bone Remodeling (drug effects)
• Female
• Humans
• Inflammation (blood, drug therapy)
• Male
• Middle Aged