Macrophage Inflammatory Proteins (Macrophage Inflammatory Protein 1)

Heparin-binding proteins that exhibit a number of inflammatory and immunoregulatory activities. Originally identified as secretory products of MACROPHAGES, these chemokines are produced by a variety of cell types including NEUTROPHILS; FIBROBLASTS; and EPITHELIAL CELLS. They likely play a significant role in respiratory tract defenses.

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Networked: 856 relevant articles (14 outcomes, 85 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Abe, Masahiro: 5 articles (04/2008 - 09/2002)
2.	Haskó, György: 4 articles (01/2022 - 05/2002)
3.	Terpos, Evangelos: 4 articles (03/2009 - 10/2003)
4.	Matsumoto, Toshio: 4 articles (04/2008 - 09/2002)
5.	Mukhopadhyay, Partha: 3 articles (01/2022 - 05/2011)
6.	Pacher, Pal: 3 articles (01/2022 - 09/2009)
7.	Chen, Changjie: 3 articles (10/2018 - 08/2011)
8.	Li, Yu: 3 articles (10/2018 - 04/2017)
9.	Yang, Qingling: 3 articles (10/2018 - 08/2011)
10.	Gopichandran, Nadia: 3 articles (01/2017 - 03/2006)

Related Diseases

1.	Infections 10/01/2001 - "Macrophage inflammatory protein 1alpha/CCL3 is required for clearance of an acute Klebsiella pneumoniae pulmonary infection." 10/01/2001 - "The objective of these studies was to determine the role of macrophage inflammatory protein 1alpha/CCL3 in pulmonary host defense during Klebsiella pneumoniae infection. " 07/14/2023 - "The cells from the HIV- partner showed significant resistance to R5 fusion/infection and had no chemotactic response to CCL4 (macrophage inflammatory protein 1β). " 12/01/2022 - "The infection group had significantly higher injury severity score (ISS), Acute Physiology and Chronic Health Evaluation II (APACHE II) score, sTREM-1, PCT, CRP, and macrophage inflammatory protein (MIP)-1α, longer tracheal intubation time and intensive care unit (ICU) stay time, and lower oxygenation index than those of the non-infection group (p < 0.05). " 03/13/2014 - "During Listeria monocytogenes infection, we observed markedly reduced secretion of macrophage inflammatory protein-1 alpha (MIP-1α) in livers of GrzM-deficient mice, which resulted in significantly impaired NK cell recruitment. "
2.	Neoplasms (Cancer) 05/01/2000 - "Macrophage inflammatory protein 3alpha transgene attracts dendritic cells to established murine tumors and suppresses tumor growth." 11/15/1999 - "The high numbers of immature DCs found in the tumor may be best explained by high levels of macrophage inflammatory protein 3alpha expression by virtually all tumor cells. " 07/01/1997 - "In addition, we have observed a striking correlation between expression of macrophage-inflammatory protein 1alpha (MIP1alpha) and selective accumulation of CD8 T cells in the tumors. " 03/01/2009 - "Immunotherapy of tumors with recombinant adenovirus encoding macrophage inflammatory protein 3beta induces tumor-specific immune response in immunocompetent tumor-bearing mice." 06/01/2007 - "Here we describe that myeloid DCs (mDCs) efficiently accumulate in tumor sites after intravenous injection of recombinant macrophage inflammatory protein (MIP)-1alpha when pretreated locally with adjuvants like Propionibacterium acnes. "
3.	Necrosis 07/01/2013 - "CD3(+) T cells from both compartments were expanded with Dynal anti-CD3/CD28 expander beads for 14 days and flow cytometry was used to evaluate four T-cell functions (CD107a, IFN-γ, tumour necrosis factor-α and macrophage inflammatory protein-1β) from 16 women. " 05/01/2022 - "The inflammatory response (cell count and immunohistochemical analysis of interleukin [IL]-1β, IL-6, tumour necrosis factor [TNF]-α, IL-17 and macrophage inflammatory protein-3α) was analysed by the implantation of a sample from each group in the subcutaneous tissue of 20 Wistar rats and evaluated after seven, 15, 30 and 60 days. " 08/01/2012 - "Ang-1 and Ang-2 stimulated activation of multiple intracellular signalling pathways, and cooperated with tumour necrosis factor to induce macrophage interleukin 6 and macrophage inflammatory protein 1α production. " 02/01/2012 - "Concomitantly, compound 1 inhibited the accumulation of granulocytes as well as the expression of inflammatory proteins such as tumour necrosis factor-α, interleukin-1β and macrophage inflammatory proteins 1α and 1β in the ear tissue. " 11/01/2011 - "Functional subsets of Gag- and Nef-specific CD8(+) cells were analysed based on the production of macrophage inflammatory protein (MIP)-1β, tumour necrosis factor (TNF)-α and interleukin (IL)-2. "
4.	Inflammation (Inflammations) 08/01/2010 - "Viral macrophage inflammatory protein-II significantly improved acute glomerular damage and tubulointerstitial inflammation and lowered the extent of vascular and tubulointerstitial damage of the treated allografts. " 09/04/2000 - "Langerhans cells (LCs) represent a unique population of DCs colonizing epithelium, and we present here observations suggesting that macrophage inflammatory protein (MIP)-3alpha plays a central role in LC precursor recruitment into the epithelium during inflammation. " 01/15/2000 - "We found that these cells respond to macrophage-inflammatory protein (MIP)-1alpha, enhancing their ability to invade ECM and supporting the idea that immature DC are selectively recruited at the site of inflammation to expand the pool of APCs. " 01/01/1995 - "Since macrophage inflammatory protein-1 alpha (MIP-1 alpha) has previously been found to be chemotactic for eosinophils, in vitro, we postulated that MIP-1 alpha was involved in the airway inflammation and more specifically in eosinophil recruitment into the airway. " 01/01/2014 - "The macrophage inflammatory proteins MIP1α (CCL3) and MIP2α (CXCL2) in implant-associated osteomyelitis: linking inflammation to bone degradation."
5.	Melanoma (Melanoma, Malignant) 12/14/2001 - "The 5'-flanking sequences of the human macrophage inflammatory protein-3alpha/CCL20 gene were cloned and transfected into G-361 human melanoma cells in a luciferase reporter construct. " 08/14/2023 - "Previous studies in the B16F10 mouse melanoma model have demonstrated that combining a DNA vaccine comprised of regions of gp100 and tyrosinase-related protein 2 fused to Macrophage-inflammatory protein 3-alpha (MIP3α) with recombinant Interferon alpha (IFN) and 5-Aza-2'-Deoxycytidine (5Aza) treatments resulted in significantly greater anti-tumor activity and immunogenicity in the tumor microenvironment (TME). " 02/01/2000 - "The purpose of this study is to determine the effects of alpha-chemokines (IL-8 and melanoma growth-stimulating activator), beta-chemokines (monocyte chemotactic protein 1, macrophage inflammatory protein 1alpha [MIP-1alpha], MIP-1beta, and RANTES), and proinflammatory cytokines (IL-1beta, TNF-alpha, and IFN-gamma) on the expression of both ET-1 and endothelin-converting enzyme 1 (ECE-1) by human umbilical vein endothelial cells. " 05/01/1994 - "In the present study, the action of chemokines/intercrines on the regulation of feeding was investigated using the intracerebroventricular microinfusion of chemokine/intercrine-alpha subfamily members [interleukin-8 (IL-8); growth-related cytokine/melanoma growth-stimulating activity (GRO-alpha/MGSA); platelet factor-4 (PF-4); beta-thromboglobulin (beta-TG); and interferon-inducible protein-10 (IP-10)] and beta-subfamily members [monocyte chemotactic protein-1/monocyte chemotactic and activating factor (MCP-1/MCAF); regulated upon activation normal T-cell expressed and presumably secreted (RANTES); macrophage inflammatory protein-1 alpha (MIP-1 alpha); and macrophage inflammatory protein-1 beta (MIP-1 beta)]. " 07/01/2012 - "Flt-3 ligand, interleukin (IL) 1α, IL-6, IL-8, interferon-γ inducible protein (IP)-10, monocyte chemoattractant protein 1 (MCP-1), macrophage inflammatory protein 1α, platelet-derived growth factor AA, and vascular endothelial growth factor were significantly elevated in aqueous and vitreous of melanoma eyes when compared with controls. "

Related Drugs and Biologics

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2.	Chemokine CCL5
3.	Interleukins
4.	Cytokines
5.	Proteins (Proteins, Gene)
6.	Interleukin-10 (Interleukin 10)
7.	Interleukin-6 (Interleukin 6)
8.	CC Chemokines
9.	Vaccines
10.	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Aftercare (After-Treatment)
4.	Radiotherapy
5.	Microspheres (Microsphere)