Objective. We hypothesised that the endothelial dysfunction is associated with early
glucose dysregulation and/or
atherosclerosis risk factors in nondiabetic women with a previous history of
gestational diabetes (pGDM). Material/Methods. Anthropometric parameters,
glucose regulation (OGTT),
insulin resistance (HOMA),
lipids,
biomarkers of endothelial dysfunction, and
inflammation were evaluated in 85 women with pGDM and in 40 controls 2-24 months postpartum. Results. The pGDM group consisted of 67% normoglycemic women (pGDM-N) and 33% with
prediabetic state (pGDM-P). The BMI, waist circumference, fasting and 2 h
glucose (OGTT), soluble adhesion molecules,
tissue plasminogen activator antigen,
high sensitivity C-reactive protein, total-,
LDL-cholesterol, and
triglycerides/
HDL-cholesterol ratio were higher in the pGDM women compared with the controls. After adjustment for BMI and fasting
glucose, only higher
triglycerides, higher TG/HDL and lower
HDL-cholesterol were associated with pGDM. The pGDM-P differed from pGDM-N for only higher
triglycerides and TG/HDL. The plasma level of sE-
selectin was not independently associated with
glucose concentration in pGDM group. sE-
selectin level correlated with
triglycerides, TG/HDL,
plasminogen activator inhibitor-1
antigen, and sICAM-1. Conclusions. sE-
selectin level correlated with components of
metabolic syndrome, but only the atherogenic
lipid profile was independently associated with a previous history of GDM in nondiabetic women 2-24 months postpartum.