Abstract | OBJECTIVE: DESIGN: Cross-sectional study of 116 HIV-infected outpatients. METHODS: Doppler-echocardiography and pulmonary function testing were performed. Induced sputum and plasma cytokines, sputum cell counts and differentials, markers of peripheral T-cell activation, and serum N-terminal pro- brain natriuretic peptide ( NT-proBNP) were measured. Univariate and multivariate analyses determined relationship of echocardiographic variables to pulmonary function, inflammation, and NT-proBNP. RESULTS: Mean estimated pulmonary artery systolic pressure ( PASP) was 34.3 mmHg (SD 6.9) and mean tricuspid regurgitant jet velocity (TRV) was 2.5 m/s (SD 0.32). Eighteen participants (15.5%) had PASP of at least 40 mmHg, and nine (7.8%) had TRV of at least 3.0 m/s. Elevated TRV was significantly associated with CD4 cell counts below 200 cells/μl and higher log HIV- RNA levels. Forced expiratory volume in 1 s (FEV(1)) percentage predicted, FEV(1)/forced vital capacity, and diffusing capacity for carbon monoxide (DLco) percentage predicted were significantly lower in those with elevated PASP or TRV. Sputum interleukin-8, peripheral interleukin-8, peripheral interferon-γ levels, and CD8(+) T-cell expression of CD69(+) were associated with increasing PASP and TRV. Log NT-proBNP was significantly higher with increasing PASP and TRV. Left ventricular function was not associated with PASP or TRV. CONCLUSION:
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Authors | Alison Morris, Matthew R Gingo, M Patricia George, Lorrie Lucht, Cathy Kessinger, Vikas Singh, Maria Hillenbrand, Michelle Busch, Deborah McMahon, Karen A Norris, Hunter C Champion, Mark T Gladwin, Yingze Zhang, Chad Steele, Frank C Sciurba |
Journal | AIDS (London, England)
(AIDS)
Vol. 26
Issue 6
Pg. 731-40
(Mar 27 2012)
ISSN: 1473-5571 [Electronic] England |
PMID | 22210636
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Cytokines
- Peptide Fragments
- RNA, Viral
- pro-brain natriuretic peptide (1-76)
- Natriuretic Peptide, Brain
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Topics |
- Biomarkers
(metabolism)
- CD4 Lymphocyte Count
- Cross-Sectional Studies
- Cytokines
(blood)
- Echocardiography, Doppler
- Female
- Forced Expiratory Volume
- HIV Infections
(complications, immunology, physiopathology)
- Humans
- Hypertension, Pulmonary
(complications, diagnosis)
- Male
- Middle Aged
- Natriuretic Peptide, Brain
(blood)
- Peptide Fragments
(blood)
- RNA, Viral
- Respiratory Function Tests
- Risk Factors
- Sputum
(chemistry)
- Vital Capacity
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