Abstract | BACKGROUND: METHODS: RESULTS: A total of 147 cases (44.5%) showed strong CAIX expression (AC: 46.7%; ACC: 41.9%). CAIX status of the primary tumor influenced CAIX expression in corresponding lymph node metastases (P<0.001, linear regression). High CAIX-expression was an independent prognostic factor for shorter overall and disease-free survival (P≤0.05, Cox regression). Twenty-nine ACs (15.9%) and 6 SCCs (4.1%) showed Her-2 overexpression. In AC, a significant positive correlation between the Her-2 status and CAIX expression was found (P=0.009, chi-square test). CONCLUSIONS:
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Authors | Peter Birner, Bettina Jesch, Julia Friedrich, Martin Riegler, Johannes Zacherl, Michael Hejna, Fritz Wrba, Andrea Schultheis, Sebastian F Schoppmann |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 18
Issue 12
Pg. 3330-7
(Nov 2011)
ISSN: 1534-4681 [Electronic] United States |
PMID | 21519917
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- CA11 protein, human
- Nerve Tissue Proteins
- ERBB2 protein, human
- Receptor, ErbB-2
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Topics |
- Adenocarcinoma
(metabolism, secondary)
- Barrett Esophagus
(metabolism, pathology)
- Biomarkers, Tumor
(metabolism)
- Carcinoma, Squamous Cell
(metabolism, secondary)
- Cohort Studies
- Disease Progression
- Esophageal Neoplasms
(metabolism, pathology)
- Female
- Follow-Up Studies
- Humans
- Immunoenzyme Techniques
- Lymphatic Metastasis
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(metabolism, pathology)
- Nerve Tissue Proteins
(metabolism)
- Prognosis
- Receptor, ErbB-2
(metabolism)
- Survival Rate
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